Flavonoids and Sterols from Zygophyllum fabago

Abdelhamid, Reda A.; Ross, Samir A.; Abilov, Zharylkasyn A.; Султанова, Н. А.

doi:10.1007/s10600-016-1628-1

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…The flavonoids were represented at 30.35% of the total LC-MS chromatogram constituents while two-third of this percentage were calculated to be tiliroside (kaempferol-3-O-(6′′′′- p -coumaroyl)-glucoside) ( 21 ) ( Figure 1 ), as the major flavonoid glycoside content in the plant’s mother liquor, aq.-ethanolic extract. The compounds 19 , 20 , 25 , and 28 have also been previously identified in plant extracts of genus Zygophyllum [ 30 , 33 ]. However, all other identified flavonoids were recorded for the first time from the genus Zygophyllum and the species, Z. coccineum .…”

Section: Resultsmentioning

confidence: 99%

“…The sugar/s type in the flavonoid glycosides was confirmed by the MS fragmentation patterns in the respective spectra of these compounds, i.e., subtraction of 162 amu and 146 amu revealed elimination of glucose and rhamnose units from the corresponding glycone which was observed in the fragmentation patterns of the quercetin-4 -O-glucopyranoside (13), and rutin (19), respectively. The chemotaxonomic marker of the genus Zygophyllum, i.e., isorhamnetin-3-O-rutinoside (25) 19, 20, 25, and 28 have also been previously identified in plant extracts of genus Zygophyllum [30,33]. However, all other identified flavonoids were recorded for the first time from the genus Zygophyllum and the species, Z. coccineum.…”

Section: Identification and Profiling Of Z Coccineum Constituents Bymentioning

confidence: 87%

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Phytochemical Profiling, In Vitro and In Silico Anti-Microbial and Anti-Cancer Activity Evaluations and Staph GyraseB and h-TOP-IIβ Receptor-Docking Studies of Major Constituents of Zygophyllum coccineum L. Aqueous-Ethanolic Extract and Its Subsequent Fractions: An Approach to Validate Traditional Phytomedicinal Knowledge

et al. 2021

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Zygophyllum coccineum, an edible halophytic plant, is part of the traditional medicine chest in the Mediterranean region for symptomatic relief of diabetes, hypertension, wound healing, burns, infections, and rheumatoid arthritis pain. The current study aimed to characterize Z. coccineum phytoconstituents, and the evaluations of the anti-microbial-biofilm, and anti-cancers bioactivities of the plant’s mother liquor, i.e., aqueous-ethanolic extract, and its subsequent fractions. The in silico receptors interaction feasibility of Z. coccineum major constituents with Staph GyraseB, and human topoisomerase-IIβ (h-TOP-IIβ) were conducted to confirm the plant’s anti-microbial and anti-cancer biological activities. Thirty-eight secondary metabolites of flavonoids, stilbene, phenolic acids, alkaloids, and coumarin classes identified by LC-ESI-TOF-MS spectrometric analysis, and tiliroside (kaempferol-3-O-(6′′′′-p-coumaroyl)-glucoside, 19.8%), zygophyloside-F (12.78%), zygophyloside-G (9.67%), and isorhamnetin-3-O-glucoside (4.75%) were identified as the major constituents. A superior biofilm obliteration activity established the minimum biofilm eradication concentration (MBEC) for the chloroform fraction at 3.9–15.63 µg/mL, as compared to the positive controls (15.63–31.25 µg/mL) against all the microbial strains that produced the biofilm under study, except the Aspergillus fumigatus. The aqueous-ethanolic extract showed cytotoxic effects with IC50 values at 3.47, 3.19, and 2.27 µg/mL against MCF-7, HCT-116, and HepG2 cell-lines, respectively, together with the inhibition of h-TOP-IIβ with IC50 value at 45.05 ng/mL in comparison to its standard referral inhibitor (staurosporine, IC50, 135.33 ng/mL). This conclusively established the anti-cancer activity of the aqueous-ethanolic extract that also validated by in silico receptor-binding predicted energy levels and receptor-site docking feasibility of the major constituents of the plant’s extract. The study helped to authenticate some of the traditional phytomedicinal properties of the anti-infectious nature of the plant.

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Section: Resultsmentioning

confidence: 99%

Section: Identification and Profiling Of Z Coccineum Constituents Bymentioning

confidence: 87%

Phytochemical Profiling, In Vitro and In Silico Anti-Microbial and Anti-Cancer Activity Evaluations and Staph GyraseB and h-TOP-IIβ Receptor-Docking Studies of Major Constituents of Zygophyllum coccineum L. Aqueous-Ethanolic Extract and Its Subsequent Fractions: An Approach to Validate Traditional Phytomedicinal Knowledge

et al. 2021

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“…Plants from the Zygophyllaceae family are widely used in folk medicine as diuretic, anthelmintic, anti‐diabetic, anti‐rheumatic, anti‐asthmatic, and antihypertensive agents . A plethora of studies revealed the presence of flavonoids, phenolic acids, lignans, triterpenoids and sterols in such family …”

Section: Introductionmentioning

confidence: 99%

A Rare Triterpenoidal Saponin Isolated and Identified fromTetraena simplex(L.) Beier &Thulin (Syn.Zygophyllum simplexL.)

et al. 2020

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Tetraena simplex (L.) Beier & Thulin (syn. Zygophyllum simplex L.) is an annual, succulent plant belonging to family Zygophyllaceae. The plant grows in harsh environmental conditions and it is traditionally used as an analgesic and anti‐inflammatory agent. This study aims to isolate and identify phytochemical constituents of the n‐butanol fraction of its aerial parts that was repeatedly chromatographed on Diaion HP‐20 and silica gel columns to yield a rare triterpenoidal saponin, 3‐O‐[β‐D‐glucopyranosyl‐(1→2)‐β‐D‐glucopyranosyl] quinovic acid‐28‐O‐β‐D‐glucopyranosyl ester (1) along with three other known triterpenoidal compounds namely; 3‐O‐methoxy‐quinovic acid (2), quinovic acid (3), and 3‐O‐β‐D‐glucopyranosyl‐quinovic acid (4). Moreover, quercetin 3‐O‐α‐L‐rhamnoside (5) was isolated from this fraction. Different spectroscopic techniques including one dimensional (1D) and two dimensional (2D) NMR (Nuclear Magnetic Resonance) spectroscopy allowed the unambiguous structure elucidation of the isolated compounds.

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“…Such activities were contributed to their phytochemical constituents. Various classes of compounds including triterpenes, flavonoids, saponins, sterols, phenolic, essential oils and esters have been isolated from different Zygophyllum species [18][19][20][21][22][23] . 18,24 Egypt, Tunisia, Cyprus Rheumatism, gout, asthma and hypertension Z. album 8 Egypt, Algeria, Tunisia Diabetes, dermatitis, spasms and dysmenorrheal Z. atriplicoides (Synonym: Z. eurypterum) 25…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Genus Zygophyllum

Shawky

Gabr

Elgindi

et al. 2019

Journal of Advanced Pharmacy Research

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Objectives: This study aimed to make a broad review of the chemical constituents and biological activities of genus Zygophyllum. Methods: This review covers the peer reviewed articles between 1977 and August, 2018, retrieved from PubMed, Science Direct, Sci-Hub, Springer and Wikipedia Results: In traditional medicine, plants of genus Zygophyllum have been employed and utilized as anti-rheumatic, anti-gout, antidiabetic, anti-hyperlipidemic, antimicrobial, antioxidant, antihypertensive, antiseptic, anti-eczema and antidiarrheal. Zygophyllum species have been phytochemically studied leading to the identification of various classes of compounds including triterpenes, flavonoids, saponins, sterols, simple phenolic compounds, and esters. Biological studies on Zygophyllum species have also indicated various bioactive potentials including antioxidant, antidiabetic, antimicrobial antitumor and anti-inflammatory effects. The reported medicinal Zygophyllum species were selected and summarized on basis of their; geographical distribution, traditional uses, chemical constituents and biological activities. Conclusion: It would therefore be important to extensively investigate their phytochemicals and pharmacologically determine their activities for future drug discovery and development.

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Flavonoids and Sterols from Zygophyllum fabago

Cited by 6 publications

References 6 publications

A Rare Triterpenoidal Saponin Isolated and Identified fromTetraena simplex(L.) Beier &Thulin (Syn.Zygophyllum simplexL.)

A Comprehensive Review on Genus Zygophyllum

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