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citations
Cited by 84 publications
(70 citation statements)
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References 43 publications
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“…Similar suggestion has been reported by Daskalova et al They found that phenolic compounds in berry showed the antioxidant properties, anti-atherogenic effects, as well as, cardioprotective effects in aging rats(Daskalova et al, 2015). A meta-analysis of prospective cohort studies had revealed a positive correlation between higher consumption of flavonoids and lower risk of mortality in cardiovascular diseases both in men and women(Kim & Je, 2017). In the aging rat, long-term treatment of flavonoid significantly declined fibrosis, encouraged citrate synthase activity and maintained the mitochondrial membrane potential(Testai et al, 2020).…”
supporting
confidence: 78%
“…Similar suggestion has been reported by Daskalova et al They found that phenolic compounds in berry showed the antioxidant properties, anti-atherogenic effects, as well as, cardioprotective effects in aging rats(Daskalova et al, 2015). A meta-analysis of prospective cohort studies had revealed a positive correlation between higher consumption of flavonoids and lower risk of mortality in cardiovascular diseases both in men and women(Kim & Je, 2017). In the aging rat, long-term treatment of flavonoid significantly declined fibrosis, encouraged citrate synthase activity and maintained the mitochondrial membrane potential(Testai et al, 2020).…”
supporting
confidence: 78%
“…Our study cohort had a median age of 56 years (IQR 52-60) at entry and a median follow-up of 21 years (15)(16)(17)(18)(19)(20)(21)(22). During a total of 939 031 person-years of followup, 8773 individuals were admitted to hospital for any atherosclerotic cardiovascular disease, 5323 for ischaemic heart disease, 2920 for ischaemic stroke, and 1867 for peripheral artery disease.…”
Section: Resultsmentioning
confidence: 99%
“…19,20 A 2017 meta-analysis found that total flavonoid intake was marginally, but not significantly, associated with a lower risk of cardiovascular disease mortality (relative risk 0·85, 95% CI 0·70-1·03) for the highest versus lowest category of total flavonoid intake; 18 similar risk estimates have been reported in other meta-analyses. 21,22 Indeed, our previous study in the Danish Diet Cancer, and Health cohort showed that participants in the highest quintile of flavonoid intake had a 15% lower risk of cardiovascular disease mortality (HR 0·85, 95% CI 0·78-0·93) than that of participants in the first quintile. 23 Although a trend for a reduced risk of cardiovascular disease with higher levels of flavonoid intake exists, this is generally non-significant after adjusting for potential con founders.…”
Section: Discussionmentioning
confidence: 98%
“…Two SRMAs of observational studies found that the risk of CVD mortality and stroke in people having a high flavonoid intake was significantly lower than those with a low intake, with pooled RRs of 0.86 (95%CI: 0.75-0.98; Figure 4C) and 0.80 (95%CI: 0.65-0.98; Figure 5A) [59,60]. However, the risk of all-cause mortality was not significantly different between the two groups [59] (see Figure 4A).…”
Section: Flavonoidmentioning
confidence: 99%