Flash visual evoked potentials in mice can be modulated by transcranial direct current stimulation

Cambiaghi, Marco; Teneud, Luis; Velikova, S.; González-Rosa, Javier J.; Cursi, Marco; Comı, Gıancarlo; Leocani, Letizia

doi:10.1016/j.neuroscience.2011.04.022

Cited by 38 publications

(26 citation statements)

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“…Besides spontaneous neuronal activity, dc stimulation was also shown to influence the cortical somatosensory and motor evoked responses in rats and cats [78], [80]. More recently similar studies conducted in mice confirmed that tDCS could modulate motor [124] and visual [125] evoked responses in a polarity-specific way.…”

Section: Large-scale Systems: Insights From In Vivo Modelsmentioning

confidence: 83%

Transcranial Current Brain Stimulation (tCS): Models and Technologies

Ruffini

Wendling

Merlet

et al. 2013

IEEE Trans. Neural Syst. Rehabil. Eng.

156

157

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Abstract-In this paper, we provide a broad overview of models and technologies pertaining to transcranial current brain stimulation (tCS), a family of related noninvasive techniques including direct current (tDCS), alternating current (tACS), and random noise current stimulation (tRNS). These techniques are based on the delivery of weak currents through the scalp (with electrode current intensity to area ratios of about 0.3-5 A/m ) at low frequencies (typically 1kHz) resulting in weak electric fields in the brain (with amplitudes of about 0.2-2 V/m). Here we review the biophysics and simulation of noninvasive, current-controlled generation of electric fields in the human brain and the models for the interaction of these electric fields with neurons, including a survey of in vitro and in vivo related studies. Finally, we outline directions for future fundamental and technological research.Index Terms-Brain stimulation, electrical stimulation, transcranial alternating current (tACS), transcranial current stimulation (tCS), transcranial direct current (tDCS), transcranial random noise current stimulation (tRNS).

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Section: Large-scale Systems: Insights From In Vivo Modelsmentioning

confidence: 83%

Transcranial Current Brain Stimulation (tCS): Models and Technologies

Ruffini

Wendling

Merlet

et al. 2013

IEEE Trans. Neural Syst. Rehabil. Eng.

156

157

View full text Add to dashboard Cite

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“…Recent studies aimed at developing and validating animal models of transcranial electrical stimulation have shown modulation of TMS evoked potentials and visual evoked potentials consistent with the somatic doctrine (Cambiaghi et al, 2010, Cambiaghi et al, 2011). In a pioneering work using uniform electric fields in brain slices, Jefferys showed acute modulation of excitability (synaptically driven population spikes) in the dentate gyrus of hippocampal slices when electric fields were parallel to the primary target cell dendritic axis.…”

Section: Synaptic Processing and Plasticitymentioning

confidence: 99%

Animal models of transcranial direct current stimulation: Methods and mechanisms

Jackson

Rahman

Lafon

et al. 2016

Clinical Neurophysiology

235

201

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The objective of this review is to summarize the contribution of animal research using direct current stimulation (DCS) to our understanding of the physiological effects of transcranial direct current stimulation (tDCS). We comprehensively address experimental methodology in animal studies, broadly classified as: 1) transcranial stimulation; 2) direct cortical stimulation in vivo and 3) in vitro models. In each case advantages and disadvantages for translational research are discussed including dose translation and the overarching “quasi-uniform” assumption, which underpins translational relevance in all animal models of tDCS. Terminology such as anode, cathode, inward current, outward current, current density, electric field, and uniform are defined. Though we put key animal experiments spanning decades in perspective, our goal is not simply an exhaustive cataloging of relevant animal studies, but rather to put them in context of ongoing efforts to improve tDCS. Cellular targets, including excitatory neuronal somas, dendrites, axons, interneurons, glial cells, and endothelial cells are considered. We emphasize neurons are always depolarized and hyperpolarized such that effects of DCS on neuronal excitability can only be evaluated within subcellular regions of the neuron. Findings from animal studies on the effects of DCS on plasticity (LTP/LTD) and network oscillations are reviewed extensively. Any endogenous phenomena dependent on membrane potential changes are, in theory, susceptible to modulation by DCS. The relevance of morphological changes (galvanotropy) to tDCS is also considered, as we suggest microscopic migration of axon terminals or dendritic spines may be relevant during tDCS. A majority of clinical studies using tDCS employ a simplistic dose strategy where excitability is singularly increased or decreased under the anode and cathode, respectively. We discuss how this strategy, itself based on classic animal studies, cannot account for the complexity of normal and pathological brain function, and how recent studies have already indicated more sophisticated approaches are necessary. One tDCS theory regarding “functional targeting” suggests the specificity of tDCS effects are possible by modulating ongoing function (plasticity). Use of animal models of disease are summarized including pain, movement disorders, stroke, and epilepsy.

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“…Actually, it has been demonstrated that in rodents both rTMS and tDCS have effects similar to those observed in humans 9 ; however, detailed mechanistic insights are still missing and will probably derive from further animal studies. Working with transcranial stimulation will require a strong collaboration among clinicians of different disciplines and translational research programs, so to facilitate bench-to-bedside translation in developing cohesive patient-oriented treatment plans.…”

Section: An Interdisciplinary Fieldmentioning

confidence: 99%