Flash nanoprecipitation of ultra-small semiconducting polymer dots with size tunability

He, Yuezhen; Fan, Xinyue; Sun, Jian; Liu, Rui; Fan, Zhen; Zhang, Zhijie; Chang, Xiaofeng; Wang, Baojuan; Gao, Feng; Wang, Lun

doi:10.1039/c9cc09651e

Cited by 15 publications

(16 citation statements)

References 34 publications

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“…In recent years, an emerging novel technology for NP fabrication—flash nanoprecipitation (FNP) has drawn broad attention due to the advantages of simple equipment, fast process, scalable, and continuous production of NPs with small sizes and narrow size distributions. [ 26–38 ] As compared with the conventional thermal dynamic assembly method (denoted as TM), much higher mixing intensities can be achieved by FNP with much shorter characteristic mixing times, resulting in more identical nucleation and growth micro‐environment for precipitated NPs. However, conventional FNP process usually needs complex amphiphilic block polymers to encapsulate a hydrophobic molecule for the formation of NPs.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, an emerging novel technology for NP fabrication-flash nanoprecipitation (FNP) has drawn broad attention due to the advantages of simple equipment, fast process, scalable, and continuous production of NPs with small sizes and narrow size distributions. [26][27][28][29][30][31][32][33][34][35][36][37][38] As compared with the…”

Section: Introductionmentioning

confidence: 99%

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Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Jia

Yan

Kayitmazer

et al. 2021

Adv Funct Materials

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Photothermal‐chemotherapeutic nanoparticles (NPs) are attracting increasing attention and becoming more widely used for cancer therapy in the clinic due to their noninvasiveness, notable tissue penetration abilities, and low systemic adverse effects. However, functional ligands are conventionally modified onto photothermal NPs to well stabilize the inorganic particles suffering from complex chemical modifications, low productivity, and batch‐to‐batch inconsistencies, and thus significantly restricting their clinical applications. Herein, flash nanoprecipitation (FNP) is taken advantage of to afford rapid and uniform mixing for generating local supersaturated CuS clusters for small and highly stable CuS NPs effectively stabilized by polyacrylic acid through a continuous strategy. It greatly reduces the complexity for CuS NPs synthesis and functionalization in a facile intensified mixing process. These as‐synthesized particles are high‐drug loading, scalable, and most importantly, it is easy to control their sizes and charges through external conditions. Toxicity and tumor inhibition experiments confirm the high cell toxicity and good suppression of tumor growth under near‐infrared irradiation indicating a promising prospect of FNP in the large‐scale and continuous yielding of highly stable and high‐performing photothermal‐chemotherapeutic NPs for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Jia

Yan

Kayitmazer

et al. 2021

Adv Funct Materials

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show abstract

“…In the former, the organic liquid stream and aqueous liquid stream collide from opposite jets at a high velocity. Concurrently, turbulent mixing occurs in the mixing chamber followed by mixture escape through the outlet . MIVM, on the other hand, has more inlets that do not face each other.…”

Section: Synthesis Processesmentioning

confidence: 99%

Review of Conjugated Polymer Nanoparticles: From Formulation to Applications

Kang

Yoon

Kim³

et al. 2022

ACS Appl. Nano Mater.

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Conjugated polymers, which exhibit electrical and optical properties owing to the presence of conjugated π bonds along the polymer backbone, are semiconducting materials of utmost interest. However, their immiscibility in water imposes restrictions on their usage; they are typically processed using toxic and environmentally harmful organic solvents. To address these issues, research has focused on converting conjugated polymers into nanoparticle dispersions in water or alcohols. This strategy not only avoids toxic solvent usage but also enhances application utility. In this article, to provide a comprehensive understanding of conjugated polymer nanoparticles, we introduce two principal approaches for classifying nanoparticle formation strategies and their corresponding experimental methods: with respect to the particle formation mechanisms and their preparation methods; we will discuss six such methods. Then, we review three different applications of the conjugated polymer nanoparticles in the fields of electronics, energy, and bioimaging, associating their requirements for attaining superior device performance with the characteristics of each method, and accordingly discuss methodological perspectives for each application.

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“…Beyond conventional polymers, semiconducting polymer dots with ultra‐small sizes (hydrodynamic diameters ∼10 nm) and narrower size distributions were prepared via FNP. [ 40 ] The particle size and size distribution are mainly dependent on the components and concentrations of the precursors. Rodlike charge‐conversion nanoparticles with amphiphilic biomolecules, dextran‐ b ‐poly(lactic‐ co ‐glycolic acid) and poly(2‐(dimethylamino) ethylmethylacrylate)‐ b ‐poly( ε ‐caprolactone), have been reported for new applications in aggregation‐induced emission.…”

Section: Approaches To Nanoparticles With Ordered Structuresmentioning

confidence: 99%

Synthetic advances of internally nanostructured polymer particles: From and beyond block copolymer

et al. 2020

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Polymer particles with internal nanostructures for versatile applications in many fields have attracted widespread attention. Among the diverse synthetic strategies toward polymer particles, polymer assembly in solution or melt is one of the most powerful methods to fabricate various hierarchically nanostructured materials in different length scales. In the review, we summarized the recent advances of several significant synthetic strategies of polymer particles with unique internal structures: (1) the principle of solvent exchange-induced either self-organized or scalable flash nanoprecipitation, (2) emulsion-solvent evaporation by engineering the interfacial interaction between the emulsion droplet and medium, (3) template-assisted method, and (4) polymerization-induced assembly method. In each part, we systematically describe key factors such as interfacial relationship, solvent properties, and chemical nature of polymer that dictate the formation and evolution of their morphology. Finally, we discussed remaining issues of nanostructured polymer assemblies and their potential for future applications.

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Flash nanoprecipitation of ultra-small semiconducting polymer dots with size tunability

Abstract: Schematic illustration of Pdots produced by FNP.

Cited by 15 publications

References 34 publications

Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Review of Conjugated Polymer Nanoparticles: From Formulation to Applications

Synthetic advances of internally nanostructured polymer particles: From and beyond block copolymer

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