Fixed drug eruption (phenolphthalein). Evidence for a blood-borne mediator

Copro-eosinophil cationic protein (ECP) in food allergy

“…Improvement in diagnostic accuracy has been reported with intradermal tests in some cases of drug-induced allergic contact dermatitis ( 5 , 6), but these tests have only occasionally been used for FDE diagnosis. Positive intradermal results have been reported in FDE caused by antipyrine and alurate, although negative results were obtained with phenolphthalein (7). We have found no reports of intradermal tests in the diagnosis of FDE due to cotrimoxazole.…”

Fixed drug eruption (FDE): changing scenario of incriminating drugs

“…During the past decade, several other important aspects of FDE have come to light. [197][198][199][200] Wyatt et al 196 obtained serum samples at the height of activity of fixed lesions; the serum was injected intradermally into the old lesions as well as normal skin during the course of remission. This resulted in the initiation of an inflammatory response at the site of the old lesions, but not in the areas of normal skin, thus incriminating some form of serum factor responsible for the pathogenesis of FDE.…”

“…The exact pathomechanism of FDE is still unclear. Several studies, including autotransplantation of involved skin, 194,195 searching for the causative agent, 190,191 and in vitro immunologic studies, 196 have been performed. During the past decade, several other important aspects of FDE have come to light 197–200 .…”

“…During the past decade, several other important aspects of FDE have come to light 197–200 . Wyatt et al 196 . obtained serum samples at the height of activity of fixed lesions; the serum was injected intradermally into the old lesions as well as normal skin during the course of remission.…”