“…Then she told me she took Capudine on Sunday mornings for the relief of a headache. Capudine is a patent medicine containing 8 Dr. Stephen Rothman, Chicago: In the 1910's antipyrine was the most popular analgesic in Central European countries, and in those days we saw many fixed drug eruptions due to this drug ; all of them occurred in white patients. Those eruptions were sharply circumscribed, single or multiple, erythematous edematous patches, mainly on the forehead, flaring each time after ingestion of the drug in the same area.…”