Five-year Pan-European, longitudinal surveillance of Clostridium difficile ribotype prevalence and antimicrobial resistance: the extended ClosER study

Freeman, Joseph T.; Vernon, Jon J; Pilling, Sally; Morris, K.; Nicolson, Scott; Shearman, Sharie; Clark, Emma; Palacios-Fabrega, Jose Alejandro; Wilcox, Mark H.

doi:10.1007/s10096-019-03708-7

Cited by 61 publications

(60 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The same distribution of the dominant C. difficile strains (027, 001/072 and 014/020) was found in the EUCLID study performed in Europe during 2012 and 2013, although the rate of 027 ribotype was lower than the one obtained in the present study [15]. In the last published study addressing C. difficile ribotypes Europe-wide, ribotype 027 remained the most prevalent, at the mean prevalence of 11.5% across 5 years, followed by ribotypes 001, 078, 014 and 020 [16]. On the contrary, in a recent study performed in North Macedonia, around 48% of isolates belonged to 001/072 [17].…”

Section: Resultscontrasting

confidence: 65%

See 1 more Smart Citation

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

et al. 2020

View full text Add to dashboard Cite

Background: The global epidemic of nosocomial diarrhea caused by Clostridioides (Clostridium) difficile started in 2000, with high mortality rates and emergence of a new hypervirulent strain NAP1/BI/027. The aim of this study was to assess the presence of ribotype 027 and other C. difficile ribotypes in a Serbian University Hospital, compare the temporal variability of ribotypes 3 years apart, as well as to compare clinical, demographic and laboratory characteristics and disease outcome among patients infected with 027 and non-027 ribotype. This was a prospective observational cohort study addressing 4-month intervals during 2014/2015 and 2017/2018. Results: Ribotyping was performed in 64 non-duplicate C. difficile strains. Ribotype 027 was the most prevalent, and was detected in 53 (82.8%) patients (43/45 and 10/19 patients in 2014-2015 and 2017/2018, respectively). Other detected ribotypes were 001/072 in 4 (6.3%), 002 in 4 (6.3%), 014/020 in 2 (3.1%) and 176 in 1 (1.5%) patient. The percentage of the patients infected with ribotype 027 significantly decreased during the 3-year period, from 95.6 to 52.6% (p < 0.001). Ribotype 027 infection was associated with fluoroquinolone treatment more frequently than infection with other ribotypes [33 (62.3%) vs. 2 (18.2%), p = 0.010)]. A severe C. difficile infection was diagnosed more often in patients with the detected ribotype 027 compared to those infected with non-027 ribotypes (p = 0.006). No significant difference in the mortality and recurrence rates was found between the patients infected with ribotype 027 and those infected with other ribotypes [10/53 (18.8%) vs. 2/11 (18.2%), p = 0.708, and 10/35 (28.6%) vs. 0/2 (0%), p = 1.000, respectively]. Conclusion: Clostridium difficile ribotype 027 was the most prevalent ribotype among patients in a large Serbian hospital, but there is a clear decreasing trend.

show abstract

Section: Resultscontrasting

confidence: 65%

“…As opposed to these results, Italy and Germany reported the increase in the rate of patients with ribotype 027 infection reaching 38% and 30%, respectively [23,24]. In Cyprus, its prevalence increased each year, from 28% in 2011 to 89% in 2015 [16].…”

Section: Resultsmentioning

confidence: 92%

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The same distribution of the dominant C. difficile strains (027, 001/072 and 014/020) was found in the EUCLID study performed in Europe during 2012 and 2013, although the rate of 027 ribotype was lower than the one obtained in the present study (15). In the last published study addressing C. difficile ribotypes Europe-wide, ribotype 027 remained the most prevalent, at the mean prevalence of 11.5% across five years, followed by ribotypes 001, 078, 014 and 020 (16). On the contrary, in a recent study performed in North Macedonia, around 48% of isolates belonged to 001/072 (17).…”

Section: Resultscontrasting

confidence: 64%

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Korać

Rupnik

Nikolić

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The global epidemic of nosocomial diarrhea caused by Clostridioides (Clostridium) difficile started in 2000, with high mortality rates and emergence of a new hypervirulent strain NAP1/BI/027. The aim of this study was to assess the presence of ribotype 027 and other C. difficile ribotypes in a Serbian University Hospital, compare the temporal variability of ribotypes three years apart, as well as to compare clinical, demographic and laboratory characteristics and disease outcome among patients infected with 027 and non-027 ribotype. This was a prospective observational cohort study addressing four-month intervals during 2014/2015 and 2017/2018. Results: Ribotyping was performed in 64 non-duplicate C. difficile strains. Ribotype 027 was the most prevalent, and was detected in 53 (82.8%) patients (43/45 and 10/19 patients in 2014-2015 and 2017/2018, respectively). Other detected ribotypes were 001/072 in 4 (6,3%), 002 in 4 (6,3%), 014/020 in 2 (3,1%) and 176 in 1 (1,5%) patient. The percentage of the patients infected with ribotype 027 significantly decreased during the three-year period, from 95.6% to 52.6% (p<0.001). Ribotype 027 infection was associated with fluoroquinolone treatment more frequently than infection with other ribotypes [33 (62.3%) vs. 2 (18.2%), p= 0.010)]. A severe C. difficile infection was diagnosed more often in patients with the detected ribotype 027 compared to those infected with non-027 ribotypes (p=0.006). No significant difference in the mortality and recurrence rates was found between the patients infected with ribotype 027 and those infected with other ribotypes [10/53 (18.8%) vs. 2/11 (18.2%), p=0.708, and 10/35 (28.6%) vs. 0/2 (0%), p=1.000, respectively].Conclusion: C. difficile ribotype 027 was the most prevalent ribotype among patients in a large Serbian hospital, but there is a clear decreasing trend.

show abstract

“… 12 Fidaxomicin is already in therapeutic use in several countries and fidaxomicin-resistant C. difficile strains have been reported in rare cases. 17 Ridinilazole is currently in Phase III clinical trials; to date, no resistance to ridinilazole has been reported.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the antimicrobial activity of ridinilazole and six comparators against Chinese, Japanese and South Korean strains of Clostridioides difficile

Collins

Tateda

et al. 2020

Journal of Antimicrobial Chemotherapy

View full text Add to dashboard Cite

Background Clostridioides difficile is the most common cause of antimicrobial-associated diarrhoea in high-income countries. Fluoroquinolone resistance enabled the emergence and intercontinental spread of the epidemic ribotype (RT) 027 strain ofC. difficile in the early 2000s. Despite frequent inappropriate antimicrobial use in Asia, RT 027 is rarely isolated in the region, but the often fluoroquinolone- and clindamycin-resistant RT 017 strain predominates. Objectives This study evaluated the antimicrobial activity of ridinilazole, a novel antimicrobial agent with highly specific activity forC. difficile, against clinical strains ofC. difficile from Asia. Methods C. difficile strains from Japan (n = 64), South Korea (n = 32) and China (n = 44) were tested by the agar dilution method for susceptibility to ridinilazole, metronidazole, vancomycin, clindamycin, moxifloxacin, rifaximin and fidaxomicin. Results All strains were susceptible to ridinilazole, with low MICs (0.03–0.25 mg/L). Several strains showed multiresistance profiles, particularly RT 017 (100% clindamycin resistant, 91.3% moxifloxacin resistant, 82.6% rifaximin resistant) and RT 369 (94.4% clindamycin resistant, 100% moxifloxacin resistant). Rifaximin resistance was absent in all strains from Japan. Multiresistance to clindamycin, moxifloxacin and rifaximin was found in 19 RT 017 strains (from China and South Korea), 2 RT 001 strains (South Korea) and 1 RT 046 strain (South Korea). Conclusions Ridinilazole showed potent activity against a range of AsianC. difficile strains, which otherwise frequently displayed resistance to several comparator antimicrobial agents. Ongoing surveillance of antimicrobial resistance profiles is required to monitor and control the spread of resistant strains.

show abstract

Five-year Pan-European, longitudinal surveillance of Clostridium difficile ribotype prevalence and antimicrobial resistance: the extended ClosER study

Cited by 61 publications

References 22 publications

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Evaluation of the antimicrobial activity of ridinilazole and six comparators against Chinese, Japanese and South Korean strains of Clostridioides difficile

Contact Info

Product

Resources

About