Five ETS family members, ELF-1, ETV-4, ETV-3L, ETS-1, and ETS-2 upregulate human leukocyte-associated immunoglobulin-like receptor-1 gene basic promoter activity

Cao, Qizhi; Yang, Shude; Lv, Qing; Liu, Yan; Li, Li; Wu, Xiaojie; Qu, Guiwu; He, Xiaoli; Zhang, Xiaoshu; Sun, Shuqin; Li, Boqing; An, Jing; Hu, Tao; Xue, Jiangnan

doi:10.18632/aging.101475

Cited by 5 publications

(4 citation statements)

References 29 publications

(34 reference statements)

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“…In addition, the ETS family has been shown to play a role in immunity ( 24 – 26 ). ELF1, ETV4, ETV3L, ETS1, and ETS2 can up-regulate the expression of leukocyte-associated immunoglobulin-like receptor-1, which inhibits the maturation, differentiation, and activation of immune cells ( 25 , 27 ). ELF4 can inhibit the proliferation of naive CD8+ T cells by increasing the expression of KLF4 ( 24 , 28 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated Analysis of the ETS Family in Melanoma Reveals a Regulatory Role of ETV7 in the Immune Microenvironment

Zhao

Zhang

et al. 2020

Front. Immunol.

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The ETS family modulates immune response and drug efficiency to targeted therapies, but their role in melanoma is largely unclear. In this study, the ETS family was systematically analyzed in multiple public data sets. Bioinformatics tools were used to characterize the function of ETV7 in melanoma. A prognostic model was constructed using the LASSO Cox regression method. We found that ETV7 was the only differentially expressed gene with significant prognostic relevance in melanoma. Enrichment analysis of seven independent data sets indicated ETV7 participation in various immune-related pathways. ETV7 particularly showed a strong positive correlation with CD8+ T cell infiltration. The prognostic model based on ETV7 and its hub genes showed a relatively good predictive value in training and testing data sets. Thus, ETV7 can potentially regulate the immune microenvironment in melanoma.

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Section: Introductionmentioning

confidence: 99%

Integrated Analysis of the ETS Family in Melanoma Reveals a Regulatory Role of ETV7 in the Immune Microenvironment

Zhao

Zhang

et al. 2020

Front. Immunol.

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“…Ets-1 is one of the members of the Ets family and the Ets-1 gene is located on chromosome 11 (11q24.3) in humans (Shiu and Jaimes, 2018). Ets-1 is initially confirmed to be an oncogene and recent studies corroborate that Ets-1 also has the function of regulating immune cells (Verschoor and Singh, 2013;Cao et al, 2018). Besides, Ets-1 mediates the development of systemic autoimmune diseases by regulating the immunosuppressive activity of Treg cells (Xiang et al, 2014); in Treg cells, Ets-1 affects Treg cell growth and function by regulating the stable expression of Foxp3, which is conducive to immune homeostasis (Samstein et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1

Li¹,

Xia²,

Fan³

et al. 2021

Front. Cell Dev. Biol.

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Background: Immune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder and the decreased number and immunosuppressive dysfunction of Treg cells are key promoters of ITP. However, their mechanisms in ITP development have not been fully clarified.Methods: HUWE1 mRNA and protein levels in CD4+ T cells in peripheral blood from ITP patients were assessed by quantitative real-time PCR and Western blot. HUWE1 function in ITP was estimated using flow cytometry, enzyme-linked immunosorbent assay and immunosuppression assay. Besides, the HUWE1 mechanism in reducing the number and function of Treg cells in ITP was investigated by immunoprecipitation, cycloheximide-chase assay, ubiquitin experiment and immunofluorescence assay.Results: HUWE1 expression was elevated in CD4+ T cells in peripheral blood from ITP patients and HUWE1 mRNA level was negatively correlated with platelet counts and Treg cell percentage. Moreover, the interference with HUWE1 increased the number of Treg cells and enhanced its immunosuppressive function, and the HUWE1 overexpression produced the opposite results. For the exploration of mechanism, HUWE1 interacted with E26 transformation-specific-1 (Ets-1) and this binding was dependent on the negative regulation of the phosphorylation level of Ets-1 (Thr38) and HUWE1 facilitated the ubiquitin degradation of Ets-1 protein to restrain Treg cell differentiation and weaken their immunosuppressive functions. The in vivo assay confirmed that the HUWE1 inhibitor alleviated ITP in mice.Conclusion: HUWE1 induced the immune imbalance in ITP by decreasing the number and weakening the function of Treg cells through the ubiquitination degradation of Ets-1.

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“… 8 In addition, ETV4 can induce the activity of leukocyte-associated immunoglobulin-like receptor-1 promoter, an immunoinhibitory receptor related to some autoimmune diseases and cancers. 9 Furthermore, recent evidence has shown aberrant expression of ETV4 in numerous human cancers such as prostate cancer, 10 breast cancer, 11 and ovarian cancer, 12 and confirmed its important role in promoting tumor cell proliferation, motility, and invasion.…”

Section: Introductionmentioning

confidence: 87%

E26 transformation-specific variant 4 as a tumor promotor in human cancers through specific molecular mechanisms

Jiang

Chen

et al. 2021

Molecular Therapy - Oncolytics

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E26 transformation-specific (ETS) variant 4 (ETV4) is an important transcription factor that belongs to the ETS transcription factor family and is essential for much cellular physiology. Recent evidence has revealed that ETV4 is aberrantly expressed in many types of tumors, and its overexpression is related to poor prognosis of cancer patients. Additionally, increasing studies have identified that ETV4 promotes cancer growth, invasion, metastasis, and drug resistance. Mechanistically, the level of ETV4 is regulated by some post-translation modulations in a broad spectrum of cancers. However, little progress has been made to comprehensively summarize the critical roles of ETV4 in different human cancers. Hence, this review mainly focuses on the physiological functions of ETV4 in various human tumors. In addition, the molecular mechanisms of ETV4-mediated cancer progression were elucidated, including how ETV4 modulates its downstream signaling pathways and how ETV4 is regulated by some factors. On this basis, the present review may provide a valuable therapeutics strategy for future cancer treatment by targeting ETV4-related pathways.

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Five ETS family members, ELF-1, ETV-4, ETV-3L, ETS-1, and ETS-2 upregulate human leukocyte-associated immunoglobulin-like receptor-1 gene basic promoter activity

Cited by 5 publications

References 29 publications

Integrated Analysis of the ETS Family in Melanoma Reveals a Regulatory Role of ETV7 in the Immune Microenvironment

Integrated Analysis of the ETS Family in Melanoma Reveals a Regulatory Role of ETV7 in the Immune Microenvironment

HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1

E26 transformation-specific variant 4 as a tumor promotor in human cancers through specific molecular mechanisms

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