Fitness of Children With Standard-risk Acute Lymphoblastic Leukemia During Maintenance Therapy

Moyer‐Mileur, Laurie J.; Ransdell, Lynda B.; Bruggers, Carol S.

doi:10.1097/mph.0b013e3181978fd4

Cited by 133 publications

(221 citation statements)

References 27 publications

(35 reference statements)

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“…Our findings suggest that the first year of maintenance therapy should be targeted for preventive exercise and nutrition interventions, which will support the return to a healthy lifestyle. Several pilot studies have demonstrated feasibility of such an approach (23)(24)(25), but larger scale trials of efficacy are warranted. Schema for Children's Oncology Group Protocols (treated on or according to AALL0331 or AALL0232) with notation as to when corticosteroids and cranial radiation is given.…”

Section: Discussionmentioning

confidence: 99%

Obesity and insulin resistance in pediatric acute lymphoblastic leukemia worsens during maintenance therapy.

Esbenshade¹,

Simmons²,

Koyama³

et al. 2011

JCO

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Section: Discussionmentioning

confidence: 99%

Obesity and insulin resistance in pediatric acute lymphoblastic leukemia worsens during maintenance therapy.

Esbenshade¹,

Simmons²,

Koyama³

et al. 2011

JCO

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“…A 20-week aerobic intervention of thrice weekly activity for 30-40 min after treatment improved fitness in Hodgkin lymphoma survivors. 70 In a 12-month home-based aerobic and resistance training RCT, Moyer-Mileur et al 44 found a significant increase in self-reported physical activity and fitness, but no increase in objectively measured physical activity (pedometer-measured steps). A small intervention study that included supervised and home-based exercise increased physical activity.…”

Section: Adultsmentioning

confidence: 99%

“…Twelve studies, [42][43][44][45][46][47][48][68][69][70][71][72] including two RCT 42,44 and seven high-quality studies [42][43][44][45][46]69,71 evaluated the effects of physical activity interventions on outcomes in children with pediatric cancer who did not undergo HSCT. One study of high quality 68 evaluated the effects of a single (30 min) exercise bout.…”

Section: Adultsmentioning

confidence: 99%

“…Liu et al 33 recently performed a systematic review on exercise interventions conducted in hematological cancer patients, including studies published up to September 2007. This area of research is growing considerably and several intervention studies in adult/children survivors of hematological cancer have been recently published in adults [34][35][36][37][38][39][40] and in children 28,[41][42][43][44][45][46][47] that were not included in the review by Liu et al 33 Here, we summarize the intervention data related to all the possible effects of physical activity on adult and pediatric hematological cancer survivors. The information is also detailed extensively in Supplementary Material.…”

Section: Introductionmentioning

confidence: 99%

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Exercise in adult and pediatric hematological cancer survivors: an intervention review

et al. 2010

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Observational research has shown that the physical activity levels of survivors of hematological cancer are low, with deleterious health consequences. This review summarizes the research on exercise interventions in adult and pediatric hematological cancer survivors. We searched MEDLINE, SPORTDiscus, CINAHL, Embase, Cochrane and PEDro through September 2009 for exercise intervention studies in children and adults with any type of hematological cancer. In the 24 adult intervention studies reviewed, we found strong evidence (that is, X3 high-quality studies and X75% reporting a significant benefit) for a benefit on body composition. Weak, but promising, evidence (X3 high-quality studies, but o75% reporting a significant benefit) was found for cardiorespiratory fitness, fatigue, muscle strength, physical functioning and quality of life. In pediatric interventions (13 studies), we found strong evidence for a benefit on muscle strength and cardiorespiratory fitness, particularly, if training was conducted in the hospital setting. Evidence is weak for ankle dorsiflexion, physical functioning and body composition. No exerciserelated risks were identified in adults or children studies. Though more randomized controlled trials are needed, a growing body of literature supports the notion that regular physical activity is safe and has potential benefits for both adult and pediatric hematological cancer survivors.

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“…Review more patients (21,25,(27)(28)(29)(30)(31)(32)(33)(34). Five randomized, controlled trials have been identified (28)(29)(30)(31)33) and were ranked with evidence level "2b. "…”

Section: Exercise In Pediatric Oncologymentioning

confidence: 99%

Clinical exercise interventions in pediatric oncology: a systematic review

2013

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Studies in pediatric oncology have shown a positive effect of physical activity on disease-and treatment-related side effects. Although several reviews have approved the benefits of therapeutic exercise for adult cancer patients, no systematic review exists summarizing the evidence of physical activity in pediatric oncology. We identified a total of 17 studies using the PubMed database and Cochrane library. To evaluate the evidence, we used the evaluation system of the Oxford Center for Evidence-Based Medicine 2001. The findings confirm that clinical exercise interventions are feasible and safe, especially with acute lymphoblastic leukemia (ALL) patients and during medical treatment. No adverse effects have been reported. Positive effects were found on fatigue, strength, and quality of life. Single studies present positive effects on the immune system, body composition, sleep, activity levels, and various aspects of physical functioning. Child-specific aspects such as cognitive abilities, growth, adolescence, and reintegration into peer-groups, school, and sports have barely been taken into consideration. The evidence for exercise interventions in pediatric oncology is rated level "3. " Although the results are very promising, future research of high methodological quality and focusing on child-specific aspects is needed to establish evidence-based exercise recommendations, particularly for childhood cancer patients.A s a result of improved treatment regimes in pediatric oncology, the survival rates of children with cancer have risen to ~80% for 5-y survival (1-4). Therefore, the population of childhood cancer survivors is constantly growing. Despite these positive developments, childhood cancer is associated with a wide spectrum of various disease-and treatment-related side effects that may develop into chronic diseases and therefore result in long-term consequences. A negative impact on social, psychological, and physiological levels can be observed. Inactivity (5-7), impaired cardiopulmonary and musculoskeletal function, as well as reduced motor performance levels (8,9) and cognitive abilities (10) have been detected. Current studies also examined a negative impact on psychological well-being, satisfaction, and social functioning (11). Taken together, an impaired quality of life can thus be determined (8,12).During the past few years, several studies have generated first hints describing holistic, positive effects of clinical exercise interventions in pediatric oncology. First results present an association between increased physical activity levels in childhood cancer patients and an improvement in quality of life (13). In particular, physical functioning is increased, anxiety is reduced, and social integration is encouraged (14). Considering the fact that physical activity plays a vital role in the physiological and psychosocial development of children, therapeutic exercise in pediatric oncology is particularly important. However, there is still a lack of comprehensive and evidence-based data in the field o...

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Fitness of Children With Standard-risk Acute Lymphoblastic Leukemia During Maintenance Therapy

Abstract: These results suggest that a home-based exercise intervention during maintenance therapy encouraged greater physical activity and improved cardiovascular fitness in children with standard-risk ALL. Further investigation involving larger populations of children with ALL is warranted.

Cited by 133 publications

References 27 publications

Obesity and insulin resistance in pediatric acute lymphoblastic leukemia worsens during maintenance therapy.

Obesity and insulin resistance in pediatric acute lymphoblastic leukemia worsens during maintenance therapy.

Exercise in adult and pediatric hematological cancer survivors: an intervention review

Clinical exercise interventions in pediatric oncology: a systematic review

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