2008
DOI: 10.1038/sj.emboj.7601963
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Accumulation of depolarized mitochondria within b-cells has been associated with oxidative damage and development of diabetes. To determine the source and fate of depolarized mitochondria, individual mitochondria were photolabeled and tracked through fusion and fission. Mitochondria were found to go through frequent cycles of fusion and fission in a 'kiss and run' pattern. Fission events often generated uneven daughter units: one daughter exhibited increased membrane potential (Dw m ) and a high probability of… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

99
2,433
7
18

Year Published

2009
2009
2021
2021

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 2,569 publications
(2,557 citation statements)
references
References 39 publications
99
2,433
7
18
Order By: Relevance
“…As most mitochondrial fission pathways converge on DNM1L [42,47], the reduction in DNM1L levels indicates disrupted mitochondria dynamics in GBA-PD, a defect consistent with the elongated mitochondrial phenotype we observed in Gba L444P/WT neurons (Figure 2(B)) and fibroblasts (Figure S3(D)). It has been proposed that coupled fission and fusion, followed by autophagy, plays an important role in removing dysfunctional mitochondrial components [48], and an inhibition of mitochondrial fission may impair mitochondrial degradation by autophagy.…”
Section: Discussionmentioning
confidence: 99%
“…As most mitochondrial fission pathways converge on DNM1L [42,47], the reduction in DNM1L levels indicates disrupted mitochondria dynamics in GBA-PD, a defect consistent with the elongated mitochondrial phenotype we observed in Gba L444P/WT neurons (Figure 2(B)) and fibroblasts (Figure S3(D)). It has been proposed that coupled fission and fusion, followed by autophagy, plays an important role in removing dysfunctional mitochondrial components [48], and an inhibition of mitochondrial fission may impair mitochondrial degradation by autophagy.…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, DLP1‐dependent mitochondrial fission is also required for the segregation of dysfunctional mitochondria and for their specific targeting to mitophagy. Studies demonstrated that suitable mitochondrial fission is required for damaged mitochondria before removal by mitophagy in mouse pancreatic β cells (Twig et al ., 2008). Besides, downregulation of DLP1 has been reported to prevent mitochondrial autophagy in mouse heart (Ikeda et al ., 2015; Shirakabe et al ., 2016).…”
Section: Discussionmentioning
confidence: 99%
“…Since ACP6 exists only as a monomer, the question arose as to how activity is established. It was hypothesized that dimerization of PAP could affect the positioning of the interacting helix, which represents the scaffold for require a constant and well-regulated supply of phospholipids for membrane integrity (Twig et al, 2008;Osman et al, 2011). Moreover, this organelle also plays a role in inter-organelle traffi cking of the intermediates and products of phospholipid biosynthetic pathways (Lebiedzinska et al, 2009;Osman et al, 2011).…”
Section: Discussionmentioning
confidence: 99%