Fish oil supplements, longevity and aging

Magalhães, João Pedro de; Müller, Michael; Rainger, G. Ed; Steegenga, Wilma T.

doi:10.18632/aging.101021

Cited by 22 publications

(22 citation statements)

References 44 publications

(47 reference statements)

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“…However, it remains unclear whether this observation may be due to the use of oxidized fish oils . While fish oil shows benefits for some aging‐related disease conditions, it does not appear to improve lifespan …”

Section: Remaining Challengesmentioning

confidence: 99%

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Antiaging effects of bioactive molecules isolated from plants and fungi

Martel

Ojcius

et al. 2019

Med Res Rev

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Aging is influenced by many lifestyle choices that are under human control, including nutrition and exercise. The most effective known antiaging intervention consists of calorie restriction (CR), which increases lifespan in yeasts, worms, fruit flies, mice, and nonhuman primates. CR also improves healthspan by preventing the development of various aging‐related diseases such as cancer, cardiovascular disease, diabetes, and neurodegeneration. Many compounds isolated from plants and fungi prolong lifespan and prevent age‐related diseases in model organisms. These plant and fungal compounds modulate the same cellular and physiological pathways as CR, including those involving insulin and insulin‐like growth factor‐1, mammalian target of rapamycin, and sirtuins. Modulation of these aging‐related pathways results in the activation of various cellular processes such as autophagy, DNA repair, and neutralization of reactive oxygen species. Together, these cellular processes are believed to delay aging and prevent chronic diseases by improving bodily functions and stress resistance. We review here the mechanisms of action of plant and fungal molecules possessing antiaging properties and discuss the possibilities and challenges associated with the development of antiaging compounds isolated from natural products.

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Section: Remaining Challengesmentioning

confidence: 99%

“…337 While fish oil shows benefits for some aging-related disease conditions, it does not appear to improve lifespan. 338 It remains to be seen whether the life extension effects of phytochemicals may be applied to healthy humans.…”

mentioning

confidence: 99%

Antiaging effects of bioactive molecules isolated from plants and fungi

Martel

Ojcius

et al. 2019

Med Res Rev

View full text Add to dashboard Buy / Rent full text

show abstract

“…(CVD) [1][2][3]. Fish is a rich source of eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA), marine-derived omega-3 polyunsaturated fatty acids (PUFAs) which are the suggested mediator of such health benefits.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…inflammatory properties which prevent plaque rupture, and improvement of lipid profiles and blood pressure [3]. A 2018 meta-analysis of 77,917 older adults found that compared to placebo or open-label controls, up to 2g doses of EPA and/or DHA, supplemented for at least 12-months, did not significantly improve any pooled outcomes related to cardiovascular disease [2].…”

Section: Prevention and Treatment Of Cvdmentioning

confidence: 99%

Fish and omega-3 intake and health in older people

Marshall

Meij

2018

Maturitas

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“…The consumption of polyunsaturated fatty acids (PUFA) reportedly reduces the incidence of ischemic heart disease and prolonging one’s lifespan . In addition, it has been reported that serum levels of PUFA are closely associated with telomere shortening, indicating that serum levels of PUFA might be related to cellular senescence .…”

mentioning

confidence: 99%