Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial

Olsen, Sjúrður F.; Østerdal, Marie Louise; Salvig, Jannie Dalby; Mortensen, Lotte Maxild; Rytter, Dorte; Nj, Secher; Henriksen, Tine Brink

doi:10.1093/ajcn/88.1.167

Cited by 195 publications

(206 citation statements)

References 42 publications

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“…It was estimated that 30% of children in the placebo group would have allergies, which was conservative given that this follow-up study includes children with both single and double familial risk. Similarly, the postulated effect size of a 40% relative reduction in allergic disease was modest and realistic compared with the 67% and 59% relative reductions in child allergy outcomes reported by Furuhjelm et al 8 and Olsen et al, 16 respectively, in response to fish oil treatment during pregnancy. All analyses were performed according to the intention to treat principle.…”

Section: Sample Size and Satistical Analysismentioning

confidence: 79%

“…[9][10][11][12][13][14] However, these observational studies are unable to establish causality because of the difficulty in adjusting for complex confounding factors. 15 Randomized controlled trials (RCTs) of n-3 LCPUFA supplementation during pregnancy have reported protective effects; however, apart from 1 16-year registry based follow-up, 16 all reported allergic disease outcomes are in early childhood (between 1 and 3 years of age). 7,8,[17][18][19][20] In addition, the small sample size of a number of RCTs 7,8,19,20 introduces bias and a degree of uncertainty regarding results.…”

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confidence: 99%

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Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

et al. 2016

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BACKGROUND AND OBJECTIVE: Evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with Ω-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease characterized by an immunoglobulin E (IgE) response. We aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy.

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Section: Sample Size and Satistical Analysismentioning

confidence: 79%

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confidence: 99%

Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

et al. 2016

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“…These observations are in contrast to results from previous studies, which mainly, but not consistent, suggest that maternal fish intake during pregnancy protects against the development of childhood asthma and atopy. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Observational studies in large cohorts observed lower incidence of eczema in offspring of mothers with the highest fish consumption during pregnancy, 19,21 but not lower incidences of wheezing or asthma. In the Netherlands, fish consumption is relatively low, which can explain the differences in the observations.…”

Section: Maternal Fish Consumption and Atopic Symptoms Etm Leermakersmentioning

confidence: 99%

“…7 Many observational and interventional studies, explored the associations of maternal fish consumption or fish oil supplementation during pregnancy with the risks of childhood asthma and atopy. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Although these studies showed a protective effect on at least one outcome, they were not all able to adjust for potential confounders. Also, previous intervention studies differed in selection of participants, types of intervention and definition of outcome measures.…”

Section: Introductionmentioning

confidence: 99%

Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: The Generation R Study

et al. 2013

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BACKGROUND/OBJECTIVES: Maternal fish consumption during pregnancy might influence the fetal immune system through anti-inflammatory effects of omega-3 fatty acids, and might affect the risks of childhood asthma and atopy. In Generation R, a prospective cohort study in the Netherlands, we examined the associations of first trimester fish consumption with childhood wheezing and eczema in the first 4 years of life. METHODS: In total, 2976 mothers completed a 293-item semiquantitative food frequency questionnaire covering dietary intake in the first trimester. The occurrence of wheezing and eczema was yearly assessed by questionnaires. RESULTS: Median weekly fish consumption was 83 (95% range 0-316) grams per week. We observed no consistent associations of maternal total-, lean-or fatty-fish consumption during pregnancy with the risks of childhood wheezing. Maternal shellfish consumption of 1-13 g per week was associated with overall increased risks of childhood wheezing and eczema (OR 1.20 (1.04, 1.40) and OR 1.18 (1.01, 1.37), respectively). Maternal fatty fish consumption of 35-69 g per week was associated with increased overall risks of childhood eczema (OR 1.17 (1.00, 1.38)), but maternal total-or lean-fish consumption was not. CONCLUSIONS: During pregnancy, shellfish consumption was associated with increased risks of wheezing and eczema, while fatty fish consumption was associated with a higher risk of eczema only. Maternal total fish or lean fish consumption were not associated with wheezing or eczema. Further studies are needed to replicate these findings and to explore underlying mechanisms.

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“…However, although some authors report an association between the intake of lipids, certain fatty acids and certain foods and asthma (Bolte et al, 2005;Laerum et al, 2007;Olsen et al, 2008), others have found none (Devereux and Seaton, 2005;Almqvist et al, 2007;Kim et al, 2009;de Vries and Howie, 2009). Nevertheless, because of the fact that saturated fatty acids (SFAs) intake among children is very high nowadays, reaching the double of the recommended intake in some cases (Royo-Bordonada et al, 2006;McNeill et al, 2010), SFAs intake could be related to the increase in the prevalence of asthma.…”

Section: Introductionmentioning

confidence: 99%

Fat intake and asthma in Spanish schoolchildren

et al. 2010

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Objectives: To study the relationship between lipid, fatty acid and lipid-rich food intake and current asthma in a group of Spanish schoolchildren. Subjects/Methods: The subjects of this cross-sectional study were 638 Spanish schoolchildren (8-13 years of age). The weight and height of all the subjects were recorded. A questionnaire, completed by the subjects' parents, was used to obtain personal and health information. Current asthma was established when the children had ever had asthma, if they had been diagnosed with asthma by a doctor and if they had been treated with medications at some time in the previous 12 months. Food intake was monitored using a 3-day food record. All foods consumed were converted into energy and nutrients. Results: The energy derived from lipids, saturated fatty acids (SFAs) and myristic and palmitic acids was independently associated with current asthma (Odds Ratio (OR) third tertile 2.85 (1.01-8.07) P ¼ 0.049, 10.00 (0.89-111.97) P ¼ 0.002, 11.21 (1.36-92.24) P ¼ 0.002, 7.58 (1.40-41.03) P ¼ 0.022, respectively), as was the intake of butter (OR third tertile 2.97 (1.01-8.68) P ¼ 0.001). No relationship was seen between this condition and the intake of any other fatty acid, the n-6/n-3 ratio, nor the consumption of margarine, milk products, fish, meat, eggs or vegetable oils. Conclusions: Increased intakes of SFAs, myristic and palmitic acids and butter seem to be related to the risk of current asthma in children.

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Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial

Abstract: Under the assumption that intake of olive oil in the dose provided here was inert, our results support that increasing n-3 PUFAs in late pregnancy may carry an important prophylactic potential in relation to offspring asthma.

Cited by 195 publications

References 42 publications

Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: The Generation R Study

Fat intake and asthma in Spanish schoolchildren

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