First two cases of Monkeypox virus infection in travellers returned from UAE to India, July 2022

Yadav, Pragya; Reghukumar, Aravind; Sahay, Rima R.; Sudeep, K; Shete, Anita M.; Raman, Aruna; VK, Pramod; Abraham, Priya; Benson, Reshma; SM, Sarin; Mohandas, Sreelekshmy; Patil, Deepak Y.; Kumar, Abhinendra; Gupta, Nivedita; George, Anuja Elizabeth; Vijay, Neetu; Anuja, U; Suresh, Manjusree; A, Ramiz Raja; Sapkal, Gajanan; Ravindranath, Manasi; Sreenath, Sreenivasan; James, Preethi; MK, Shaj

doi:10.1016/j.jinf.2022.08.007

Cited by 34 publications

(36 citation statements)

References 8 publications

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“…We assessed the eligibility of the remaining 1349 studies by reading full-text papers: 1112 did not report clinical features and epidemiological characteristics of mpox; one reported duplicated cases (the one with more detailed information was included), and three reported cases before 6 May 2022 (cases confirmed in 2017–2021), one reported asymptomatic cases. Seventy-seven studies [ 4 , 8 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ,…”

Section: Resultsmentioning

confidence: 99%

Clinical Characteristics of Human Mpox (Monkeypox) in 2022: A Systematic Review and Meta-Analysis

Liu

Wang

et al. 2023

Pathogens

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Since May 2022, large numbers of monkeypox (mpox) cases have been reported in non-endemic regions. We conducted a systematic review and meta-analysis to elucidate clinical characteristics of the current mpox outbreak. Our systematic review and meta-analysis were undertaken according to PRISMA and MOOSE guidelines. We searched PubMed, EMBASE, and Web of Science for publications between 1 January and 11 November 2022. Random-effects models were used to pool results. Heterogeneity was assessed using I2. This study is registered with PROSPERO, CRD42022355590. Skin lesions (95.2%, 95% CI [93.3–96.9%]), fever (58.4%, [54.9–61.8%]) and lymphadenopathy (53.0%, [48.7–57.3%]) were the most common symptoms. The most common dermatological manifestations were anogenital lesions (65.7%, [57.8–73.0%]), and the most common lymphadenopathy was inguinal (46.8%, [40.6–53.0%]). There were no differences in symptoms including malaise, fever, headache, and genital, anal, and oropharyngeal lesions according to HIV infection status. Median age of patients varied from 15 to 57.5 years (median, 35 years). The median proportion of men who had sex with men (MSM) was 100.0% (20.6–100.0%). The median proportion of patients who reported recent sexual exposure was 99.2% (14.3–100.0%). The median proportion of PLHIV was 42.2% (0.0–100.0%). Skin lesions, fever, inguinal lymphadenopathy, and anogenital lesions were the most common symptoms of mpox reported in the current outbreak. Existing guidelines should be updated to reflect these clinical manifestations and groups at highest risk of infection, MSM in particular.

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Section: Resultsmentioning

confidence: 99%

Clinical Characteristics of Human Mpox (Monkeypox) in 2022: A Systematic Review and Meta-Analysis

Liu

Wang

et al. 2023

Pathogens

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“…The extracted viral nucleic acids were subjected to Orthopox and mpox specific real time polymerase chain reaction (PCR). 12 Of all the clinical specimens, only lesion swabs showed positivity for Orthopoxvirus, which was further confirmed as BPXV by real time PCR targeting C18L gene. 8 The lesion swabs and lesion roof collected on 7th post onset day (POD) of illness demonstrated positivity for BPXV DNA with viral load of 4.9 × 10 9 and 3.2 × 10 9 copies/ml respectively.…”

mentioning

confidence: 83%

A case of human buffalopox in Malappuram, India: The role of mpox surveillance in 2022

Patil

George

Sahay

et al. 2023

Journal of Medical Virology

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“…MPVX is not a native virus of India and there were no cases reported until 27 July 2022 where a fatal case of 22-year-old boy was noted from Kerala, 23 and after the same few more cases where being reported from India. 24 These were identified as travellers, despite of quarantine checks and all the precautions taken for the travellers, the cases travelled to India.…”

Section: Monkeypox Virus and The Indian Scenariomentioning

confidence: 99%

Monkeypox Virus: Lessons Learnt

Kulshrestha¹,

Rastogi²,

Goel³

2022

J. Pure Appl. Microbiol.

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The world has been facing a back-to-back hit to life after widespread of viruses since the time of COVID-19. The pandemic had a devastating effect and created history in mankind, but that was not enough for the time. The viruses are been known to be the deadliest microbes by virtue of their ability to reside as inactive for long time and become active again along with new variants when the conditions are favourable. One such noted spread out of virus has been that of Monkeypox Virus in humans. A zoonotic orthopoxvirus that can infect humans, the monkeypox virus (MPV) can cause disease with varied morbidity and death in humans. It has been demonstrated that members of the Orthopoxvirus genus decrease antiviral cell defences, take advantage of host cell machinery, and postpone infection-induced cell death. The name Monkeypox was after its first observation in Macaque monkey but the virus’s origin has been linked to a number of rodents and small mammals. The virus was endemic to Africa and is closely related to notorious variola (smallpox) virus. They both affect people with a febrile rash sickness that is similar to smallpox but has less severity. Monkeypox can spread from person to person and it is frequently related to breathing droplets or direct contact with mucocutaneous lesions of an affected person. There is now no cure available for those who are affected, yet supporting therapies can be used to help people with their symptoms. To better comprehend and prevent human infections, additional study is required on the epidemiology, ecology, mutations and biology of the new virus strains in endemic locations.

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First two cases of Monkeypox virus infection in travellers returned from UAE to India, July 2022

Cited by 34 publications

References 8 publications

Clinical Characteristics of Human Mpox (Monkeypox) in 2022: A Systematic Review and Meta-Analysis

Clinical Characteristics of Human Mpox (Monkeypox) in 2022: A Systematic Review and Meta-Analysis

A case of human buffalopox in Malappuram, India: The role of mpox surveillance in 2022

Monkeypox Virus: Lessons Learnt

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