First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows

Hu, Zhenhua; Fang, Cheng; Li, Bo; Zhang, Zeyu; Cao, Chuanxiang; Cai, Meishan; Su, Song; Sun, Xingwang; Shi, Xiaojing; Li, Cong; Zhou, Tiejun; Zhang, Yuanxue; Chi, Chongwei; He, Pan; Xia, Xianming; Chen, Yue; Gambhir, Sanjiv S.; Cheng, Zhen; Tian, Jie

doi:10.1038/s41551-019-0494-0

Cited by 667 publications

(483 citation statements)

References 37 publications

Supporting

Mentioning

478

Contrasting

Unclassified

Order By: Relevance

“…For example, a very recent study presented the first trial on human liver tumor surgery guided by NIR‐II imaging using the indocyanine green dye. [ 6 ]…”

Section: Figurementioning

confidence: 99%

High‐Aspect‐Ratio Plasmonic Heterostructures for In Vivo Enhanced Optical Coherence Tomography Imaging in the Second Near‐Infrared Biological Window

Zhou

Zhuang

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

Optical coherence tomography (OCT) is a noninvasive bio‐imaging modality that is widely used in both fundamental research and clinical practice. Contrast agents with strong light‐scattering properties are a prerequisite for OCT imaging. Bio‐imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has recently attracted significant attention based on reduced light absorption, suppressed photon scattering, and negligible autofluorescence. OCT contrast agents with both strong light‐scattering cross‐sections in the NIR‐II window and excellent biocompatibility are highly desirable. In this article, Ag‐based rod‐shaped plasmonic nanostructures are presented as NIR‐II OCT contrast agents. As a high‐aspect‐ratio heterostructure, the Ag nanorods coated with mesoporous silica shells (AgNR@mSiO2) are developed to achieve plasmon resonance at 1330 nm and excellent biocompatibility. By taking advantage of their huge light‐scattering cross‐sections, which provide the strongest scattering reported to date among various nanoscale OCT contrast agents, the heterostructures are used to perform efficient in vivo OCT imaging of crucian carp eyes and chicken blood vessels in the NIR‐II window. The captured images exhibit enhanced contrast with large imaging depth. These results demonstrate that the developed AgNR@mSiO2 heterostructures are promising OCT contrast agents, that can provide guidance and reference for the development of highly efficient NIR‐II imaging probes.

show abstract

“…For example, a very recent study presented the first trial on human liver tumor surgery guided by NIR‐II imaging using the indocyanine green dye. [ 6 ]…”

Section: Figurementioning

confidence: 99%

High‐Aspect‐Ratio Plasmonic Heterostructures for In Vivo Enhanced Optical Coherence Tomography Imaging in the Second Near‐Infrared Biological Window

Zhou

Zhuang

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

show abstract

“…To compete efficiently against small‐molecule CAs, nanomaterials must cause negligible biosafety risk after in vivo administration, while furnishing at least one substantial superiority, such as improved resolution, augmented imaging sensitivity, or multiplexing capability 30 . Currently, the representative nanomaterial‐based imaging modalities in clinical settings or preclinical research include MRI, 31 positron emission tomography (PET), 32 single‐photon emission computed tomography, 33 computed tomography (CT), 34 optical fluorescence imaging, 35 PA imaging, 36 and ultrasound (US) imaging 37 …”

Section: Materdicine In Bioimagingmentioning

confidence: 99%

Materdicine: Interdiscipline of materials and medicine

Xiang

Chen

2020

VIEW

View full text Add to dashboard Cite

The clinical medicine and biomaterials are two fields that are conducive to achieve the goal of precise medicine on diagnostics and therapeutics of various diseases. The interdiscipline of materials and medicine, termed/abbreviated as “materdicine,” seeks to address the dominant medical shortcomings and challenges faced by conventional medicine, including inferior bioavailability, systemic toxicity, poor targeting specificity, and unsatisfied diagnostic/therapeutic efficacy. In this review, we present the perspective and discussion on the use of diverse biomaterials for disease diagnosis and treatment from a broad perspective, especially on nanoscale biomaterials. We initially highlight the recent advances on the engineering of abundant contrast agents for diagnostic bioimaging, such as optical fluorescence imaging, magnetic resonance imaging, and photoacoustic imaging. In addition, discussions on the diagnostic biosensing for point‐of‐care diagnosis, such as fluorescent and plasmonic sensors, are supplemented. Furthermore, we outline several materdicine‐enabled therapeutic modalities for disease treatments, including the following exemplified scaffold biomaterials for regenerative medicine. Especially, rational modulation of toxicity issues of micro‐/nanoscale biomaterials is also accounted for addressing the possible concerns of biocompatibility and biosafety on further clinical translation of materdicine. Finally, we summarize facing challenges and outlook future developments relating to the clinical translation of these distinctive biomaterials in materdicine.

show abstract

“…Near-infrared (NIR) optical imaging has becomea ni mportant imaging modality for tumor detectiona nd image-guided tumor excision owing to the high imaging resolution and sensitivity as well as readily available probes and inexpensive instrumentation. [1][2][3][4] To improvet umor-imaging sensitivity and contrast, it is important to enhancet he ratio of the signal intensities of tumor to normal tissues (T/N ratio),w hich can be achieved by specifically amplifying the emissions ignal of the probesi ntumor tissues through the unique tumor microenvironment, such as the reductivea nd weakly acidic conditions and the over-expression of enzymes. [5][6][7][8][9] To accomplish this goal, different types of probes have been developed and some typical examplesa re listed here.…”

Section: Introductionmentioning

confidence: 99%

A Dendron‐Based Fluorescence Turn‐On Probe for Tumor Detection

Liu

Zhang

Zhou

et al. 2020

Chemistry A European J

View full text Add to dashboard Cite

Specifically amplifying the emission signals of optical probes in tumors is an effective way to improve the tumor-imagings ensitivity and contrast. In this paper,t he first case of dendron-based fluorescencet urn-on probes mediated by aF çrster resonance energy transfer (FRET) mechanism is reported. Dendrons up to the fourth generation with ah ydrophilic oligo(ethyleneg lycol)s caffold are synthesized by as olid-phase synthesis strategy,a nd show precise and defect-free chemical structures.T oc onstruct the fluorescence turn-on probe,o ne Cy5.5 moleculei sc onjugated to the focal of aG 3d endron through ar obust linkage and eight Black Hole Quencher3(BHQ-3) molecules are conjugatedt oi ts periphery through aP EG chainb earing ar e-ductivelyc leavable disulfidel inkage.B yi nv itro and in vivo experiments, it is demonstrated that the fluorescence of the dendron-based probec an be activated effectively and rapidly in the reductivee nvironments of tumor cellsa nd tissues, and the probe thuse xhibits amplified tumor signals and weak normalt issue signals.C ompared with the reported nanoscale turn-on probes, the dendron-based probe has several significant advantages, such as well-definedc hemical structure, precisely controllable fluorophore/quencher conjugations ites and ratio, desirable chemical stability,a nd reproducible pharmacokinetic and pharmacological profiles, and is very promising in tumor detection.

show abstract

First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows

Cited by 667 publications

References 37 publications

High‐Aspect‐Ratio Plasmonic Heterostructures for In Vivo Enhanced Optical Coherence Tomography Imaging in the Second Near‐Infrared Biological Window

High‐Aspect‐Ratio Plasmonic Heterostructures for In Vivo Enhanced Optical Coherence Tomography Imaging in the Second Near‐Infrared Biological Window

Materdicine: Interdiscipline of materials and medicine

A Dendron‐Based Fluorescence Turn‐On Probe for Tumor Detection

Contact Info

Product

Resources

About