First In-Human Burst Wave Lithotripsy for Kidney Stone Comminution: Initial Two Case Studies

Harper, Jonathan D.; Metzler, Ian; Hall, M. Kennedy; Chen, Tony T.; Maxwell, Adam D.; Cunitz, Bryan W.; Dunmire, Barbrina; Thiel, Jeff; Williams, James C.; Bailey, Michael R.; Sorensen, Mathew D.

doi:10.1089/end.2020.0725

Cited by 25 publications

(22 citation statements)

References 21 publications

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“…Its use in humans has already started within a research protocol. 1 Internet searches for medical information are colloquially called 'consulting Dr Google'. In two papers, a group from Johns Hopkins analysed the material on stones available on YouTube, and from Apple and GooglePlay apps.…”

mentioning

confidence: 99%

Which developments in urology have you missed amongst all the COVID‐19 papers?

Woodhouse

2022

Trends Urol & Men's Health

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confidence: 99%

Which developments in urology have you missed amongst all the COVID‐19 papers?

Woodhouse

2022

Trends Urol & Men's Health

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“…Recently, a novel shock wave system has been developed and is expected to be a game-changer in treating urinary calculi. It uses a combination of burst-wave lithotripsy (BWL) and ultrasound propulsion technology [ 109 110 111 ]. BWL delivers a high-frequency, focused sinusoidal acoustic wave in short bursts transcutaneously.…”

Section: Resultsmentioning

confidence: 99%

“…The device was safe and well-tolerated [ 115 ]. More recently, the first-in-human study of the BWL system has been published [ 111 ]. A 7-mm lower pole kidney stone was broken down into smaller than 2-mm fragments following nine minutes of BWL.…”

Section: Resultsmentioning

confidence: 99%

Clinical application of the therapeutic ultrasound in urologic disease: Part II of therapeutic ultrasound in urology

Choi

et al. 2022

Investig Clin Urol

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This article aimed to review the clinical application and evidence of the therapeutic ultrasound in detail for urological diseases such as prostate cancer, kidney tumor, erectile dysfunction, and urolithiasis. We searched for articles about high-intensity focused ultrasound (HIFU), extracorporeal shock wave therapy, ultrasound lithotripsy, and extracorporeal shockwave lithotripsy (ESWL) in the MEDLINE and Embase. HIFU may be indicated as a primary treatment for low- or intermediate-risk prostate cancer, and salvage therapy for local recurrence as a promising way to address the limitations of current standard therapies. The application of HIFU in treating kidney tumors has scarcely been reported with unsatisfactory results. Evidence indicates that low-intensity shockwave therapy improves subjective and objective erectile function in patients with erectile dysfunction. Regarding the application of ultrasound in stone management, the novel combination of ultrasound lithotripsy and other energy sources in a single probe promises to be a game-changer in efficiently disintegrating large kidney stones in percutaneous nephrolithotomy. ESWL is losing its role in managing upper urinary tract calculi worldwide. The burst-wave lithotripsy and ultrasound propulsion could be the new hope to regain its position in the lithotripsy field. According to our investigations and reviews, cavitation bubbles of the therapeutic ultrasound are actively being used in the field of urology. Although clinical evidence has been accumulated in urological diseases such as prostate cancer, kidney tumor, erectile dysfunction, and lithotripsy, further development is needed to be a game-changer in treating these diseases.

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“…This was used in the first clinical trial discussed below [20]. Following that trial, the device was refined to provide broader beams and longer duration exposures for ultrasonic propulsion and enabled BWL pulses with the same transducer [21][22][23][24]. The iteration of the hand held transducer used in most propulsion and BWL clinical trials to date uses a 350 kHz and 60 mm single element annular element for therapy (H209, Sonic Concepts, Bothell WA) and has within the aperture a phased array transducer (P4-2, Philips/ATL, Bothell, WA) for image guidance.…”

Section: Bme Frontiersmentioning

confidence: 99%

“…Clinical Trials. In 2021, Harper et al reported the first in-human study of BWL in two patients [24]. In the first subject, BWL was used to target a 7 mm kidney stone during general anesthesia for ureteroscopy.…”

Section: Burst Wave Lithotripsymentioning

confidence: 99%

Recent Advances in the Science of Burst Wave Lithotripsy and Ultrasonic Propulsion

2022

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Nephrolithiasis is a common, painful condition that requires surgery in many patients whose stones do not pass spontaneously. Recent technologic advances have enabled the use of ultrasonic propulsion to reposition stones within the urinary tract, either to relieve symptoms or facilitate treatment. Burst wave lithotripsy (BWL) has emerged as a noninvasive technique to fragment stones in awake patients without significant pain or renal injury. We review the preclinical and human studies that have explored the use of these two technologies. We envision that BWL will fill an unmet need for the noninvasive treatment of patients with nephrolithiasis.

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First In-Human Burst Wave Lithotripsy for Kidney Stone Comminution: Initial Two Case Studies

Cited by 25 publications

References 21 publications

Which developments in urology have you missed amongst all the COVID‐19 papers?

Which developments in urology have you missed amongst all the COVID‐19 papers?

Clinical application of the therapeutic ultrasound in urologic disease: Part II of therapeutic ultrasound in urology

Recent Advances in the Science of Burst Wave Lithotripsy and Ultrasonic Propulsion

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