First human cases of Leishmania (Viannia) naiffi infection in Ecuador and identification of its suspected vector species

Kato, Hirotomo; Calvopiña, Manuel; Criollo, Hipatia; Hashiguchi, Yoshihisa

doi:10.1016/j.actatropica.2013.09.001

Cited by 28 publications

(31 citation statements)

References 28 publications

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“…Furthermore, L. (V.) naiffi, first described as a parasite of D. novemcinctus in the northern Brazilian state of Pará [28], was later confirmed to represent a reservoir of this Leishmania species [25,29]. These and other studies also implicated the above-mentioned sand fly species in the transmission of CL in the Brazilian Amazon [25,29,[202][203][204], French Guiana [35], and the central Amazonian area Arajuno in Ecuador [205].…”

Section: (V) Naiffimentioning

confidence: 80%

Epidemiological, Biological and Clinical Aspects of Leishmaniasis with Special Emphasis on Busi Yasi in Suriname

Mans¹,

Kent²,

Hu³

et al. 2017

J Clin Exp Dermatol Res

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The parasitic disease leishmaniasis is caused by protozoa of the genus Leishmania which are transmitted by sand fly vectors of the genus Phlebotomus in the Old World and Lutzomyia in the New World. Transmission can either be anthroponotic (human to human) or zoonotic through mammalian reservoirs such as dogs and rodents. Leishmaniasis has three principal clinical manifestations, namely cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). The cutaneous form characteristically causes skin ulcers, the mucocutaneous form manifests as lesions of skin, mouth, and nose, and the (potentially lethal) visceral form affects the internal organs such as spleen and liver and also invades the bone marrow. Leishmaniasis is endemic in about ninety-eight countries and the diverse types of the disease occur in different regions of the world. CL is most common in Afghanistan, Algeria, Pakistan, Iran, Brazil, and Colombia; MCL is mainly restricted to countries of the Amazon Basin; and VL is most frequently seen in the Indian sub-continent, the Horn of Africa (Sudan and Ethiopia), and Brazil. The current global prevalence is estimated at about 12 million, and each year, the disease in one of its forms makes about 2 million new victims and claims up to 50,000 fatalities. This paper presents epidemiological, biological, and clinical aspects of leishmaniasis throughout the world; then focuses on the disease in the Republic of Suriname (South America); addresses in more detail the species of Leishmania parasites in that country; and concludes with potential future directions to improve our understanding of leishmaniasis in Suriname.

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Section: (V) Naiffimentioning

confidence: 80%

Epidemiological, Biological and Clinical Aspects of Leishmaniasis with Special Emphasis on Busi Yasi in Suriname

Mans¹,

Kent²,

Hu³

et al. 2017

J Clin Exp Dermatol Res

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“…Tomando en cuenta la notificación de los primeros casos de infección humana por L. naiffi en campos militares de entrenamiento en Ecuador, así como la presencia de esta especie en los posibles vectores asociados con la transmisión (28), sería recomendable evaluar los protocolos antes mencionados en un número mayor de cepas o diseñar identificaciones basadas en estudios de secuencias para determinar la presencia de L. naiffi y, en consecuencia, su papel clínico y epidemiológico en áreas donde hasta ahora no se conoce su circulación.…”

Section: Discussionunclassified

Identificación molecular de aislamientos clínicos de Leishmania spp. procedentes de Colombia con base en el gen hsp70

et al. 2016

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Introducción. La leishmaniasis es una enfermedad de alta prevalencia en Colombia, donde al menos seis especies diferentes pueden causar una variada presentación clínica en el humano. La tipificación de la especie es importante no solo desde el punto de vista epidemiológico, sino en el diagnóstico, dado que el tratamiento y el esquema de tratamiento pueden variar dependiendo de la especie identificada. Para la identificación se han utilizado distintas alternativas metodológicas, con variable poder discriminatorio.Objetivo. Realizar la identificación molecular de especies de Leishmania spp. mediante la amplificación molecular de un fragmento del gen hsp70.Materiales y métodos. Se realizó la amplificación molecular de un fragmento del gen hsp70: PCR-hsp70 (siglas en inglés) seguida del análisis del tamaño de los fragmentos de restricción (RFLP siglas en inglés), a 81 aislamientos clínicos de Leishmania spp., provenientes de pacientes con enfermedad cutánea y mucocutánea, en los cuales se identificaron las especies presentes.Resultados. Se obtuvo un único producto de amplificación para el total de muestras analizadas. La restricción enzimática permitió identificar 70 aislamientos con un patrón de bandas correspondiente a Leishmania braziliensis, que incluye dos patrones diferentes (62 y 8 aislamientos respectivamente); 9 aislamientos compatibles con Leishmania panamensis y 2 con Leishmania guyanensis. El origen geográfico de los aislamientos concuerda con reportes anteriores sobre la distribución de las especies correspondientes.Conclusiones. La técnica de PCR-hsp70/RFLP utilizada es útil para identificar especies de Leishmania aisladas de muestras clínicas de Colombia que puede ser aplicable también al estudio de cepas provenientes de vectores y reservorios con importancia epidemiológica.

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“…ayacuchensis has been incriminated as the vector species of L. (L.) mexicana in the Andean highlands, including study areas (Takaoka et al, 1990;Gomez and Hashiguchi, 1991;Hashiguchi et al, 1991;Kato et al, 2005Kato et al, , 2008a (Kato et al, 2008b(Kato et al, , 2013. To date, no sand flies infected by Leishmania species have been detected at subtropical study sites, and their vector competence has not been elucidated.…”

Section: ) Of These Onlymentioning

confidence: 99%

Distribution of Lutzomyia ayacuchensis, the vector of Andean-type cutaneous leishmaniasis, at different altitudes on the Andean slope of Ecuador

et al. 2014

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Distribution of the vector species is a major risk factor for the endemicity of leishmaniasis. In the present study, the vertical distribution of Lutzomyia (Lu.) ayacuchensis, the vector of Leishmania (Leishmania) mexicana in the Ecuadorian Andes was surveyed at different altitudes (300-2,500 m above sea level) of the Andean slope. The vector species Lu. ayacuchensis was identified at an altitude of 650 m and a higher areas, and higher distribution ratio of the species was observed at higher altitudes.In addition, high ratios of L. (L.) mexicana infection were detected in higher areas, but none in lower populations of sand flies. Since an association between sand fly populations and vector competence is suggested in Lu. ayacuchensis, haplotype analysis was performed on the species from different altitudes of the study areas; however, no apparent difference was observed among populations. These results suggested that Lu. ayacuchensis in Andean slope areas of Ecuador has the potential to transmit L. (L.) mexicana and spread leishmaniasis in these areas.

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First human cases of Leishmania (Viannia) naiffi infection in Ecuador and identification of its suspected vector species

Cited by 28 publications

References 28 publications

Epidemiological, Biological and Clinical Aspects of Leishmaniasis with Special Emphasis on Busi Yasi in Suriname

Epidemiological, Biological and Clinical Aspects of Leishmaniasis with Special Emphasis on Busi Yasi in Suriname

Identificación molecular de aislamientos clínicos de Leishmania spp. procedentes de Colombia con base en el gen hsp70

Distribution of Lutzomyia ayacuchensis, the vector of Andean-type cutaneous leishmaniasis, at different altitudes on the Andean slope of Ecuador

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