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Cited by 141 publications
(106 citation statements)
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References 42 publications
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“…In first-generation vaccine trials, persons with negative LST results were recruited and those who became LST positive had a lower incidence of disease but not all were protected. 28 Protection showed a maximum rate of 50%, 29 and those protected may have produced IFN-γ. The QFN test would have been a useful tool to address this issue.…”
Section: Discussionmentioning
confidence: 97%
“…In first-generation vaccine trials, persons with negative LST results were recruited and those who became LST positive had a lower incidence of disease but not all were protected. 28 Protection showed a maximum rate of 50%, 29 and those protected may have produced IFN-γ. The QFN test would have been a useful tool to address this issue.…”
Section: Discussionmentioning
confidence: 97%
“…In trials where post vaccination Mst was measured, responses were notably larger in the candidate vaccine group, but this evidence of immunogenicity induced by the candidate vaccine was not carried over to having a protective effect. Nevertheless, conversion from a negative Mst reaction to Mst > 5 mm after vaccination has been observed to be associated with a significantly lower incidence of infection in Brazil, Iran and Sudan, suggesting that Mst conversion may be associated with an immune response that provides some level of protection (Noazin et al 2008). The percentage of Mst conversion is essentially the average described by Mayrink et al (1978), which was 78.4%.…”
Section: Discussionmentioning
confidence: 97%
“…Attenuated pathogens, full organisms or inactivated bacterial toxin, which are effectively immunogenic, are used in making these vaccines. There are some advantages in these kinds of vaccines due to their high ability to stimulate innate immunity, induction of long-term protection, easy production, and low production costs (25). However, there are some disadvantages in this generation, such as inducing disease due to the use of complete pathogen (live or inactivated) and virulence recursively of the pathogen in the host body (26,27).…”
Section: First-generation Vaccinesmentioning
confidence: 99%