2020
DOI: 10.1007/s00415-020-09996-w
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Abstract: The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory… Show more

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Cited by 116 publications
(178 citation statements)
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References 10 publications
(11 reference statements)
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“…Both cases had a mild course and complete recovery further adding to the above hypothesis [ 15 ]. There is one case reported of clinical isolated syndrome in patient with COVID-19 presented with hemisensory numbness with non-confirmatory clinical definitive MS diagnosis [ 16 ] (refer Table-2 ).…”
Section: Discussionmentioning
confidence: 99%
“…Both cases had a mild course and complete recovery further adding to the above hypothesis [ 15 ]. There is one case reported of clinical isolated syndrome in patient with COVID-19 presented with hemisensory numbness with non-confirmatory clinical definitive MS diagnosis [ 16 ] (refer Table-2 ).…”
Section: Discussionmentioning
confidence: 99%
“…The hypotheses of direct infection of the CNS is also corroborated by the description of patients with COVID-19 from whom the virus was isolated in samples of CSF, which characterizes a condition of viral encephalitis, as well as the case of another patient with neck stiffness, seizures, and lowered consciousness level, who also had SARS-CoV-2 in the CSF, but not on the nasopharyngeal swab, which characterizes viral meningitis 11,21 . In addition, the detection and sequence of the virus was demonstrated in the CSF of a patient suspected of clinically isolated syndrome, a CNS demyelinating disorder 34 .…”
Section: Evidence Of Neuropathogenesismentioning
confidence: 99%
“…In the first report, PCR detected the SARS-CoV-2 in the CSF of a 40-year-old Los Angeles resident with type 2 diabetes mellitus and obesity, who developed fever and temporary loss of consciousness (syncope) and was admitted for encephalitis [156,157]. In the second report, the SARS-CoV-2 genome was detected and sequenced in a 42 year-old resident of São Paulo with suspected demyelinating disease [158]. In the third report, RT-PCR analysis detected SARS-CoV-2 in the CSF of a Japanese patient with meningitis/encephalitis associated with SARS-CoV-2 [159].…”
Section: The Blood-brain Barrier (Bbb) Routementioning
confidence: 99%
“…Although SARS-CoV-2 RNA was found in the CSF, no reports have detected and/or demonstrated the presence of the viral particles in the CSF of COVID-19 patients. Therefore, the RT-PCR positivity of the CSF samples for the SARS-CoV-2 RNA does not necessarily imply the presence of the entire infectious viral particles in there, as clearly demonstrated by the inability to detect the full-genome consensus in the CSF samples, where only 1580-nucleotides of two fragments from ORF1a were sequenced [158]. Despite all this, the data collected so far support the BBB breach as an important SARS-CoV-2 entry route.…”
Section: The Blood-brain Barrier (Bbb) Routementioning
confidence: 99%
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