First Case of Human Babesiosis in Korea: Detection and Characterization of a Novel Type of
            <i>Babesia</i>
            sp. (KO1) Similar to Ovine
            <i>Babesia</i>

Kim, Jung-Yeon; Cho, Shin‐Hyeong; Joo, Hyun-Na; Tsuji, Masayoshi; Cho, Sung Ran; Park, Il-Joong; Chung, Gyung-Tae; Ju, Jung‐Won; Cheun, Hyeng-Il; Lee, Hyeong-Woo; Lee, Younghee; Kim, Tong‐Soo

doi:10.1128/jcm.01334-06

Cited by 106 publications

(92 citation statements)

References 22 publications

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“…The results from the epidemiological evaluation, using PCRTeq, N/PCRTeq and M/PCRTeq-Bc (Table 3), characterize an endemic situation comparable to what was observed in surveys on horses in Minas Gerais, Goiás, São Paulo and Mato Grosso do Sul, using PCR techniques (Heim et al 2007, Kim et al 2007). In other countries in which T. equi is endemic, frequencies similar to those observed in this study have been found, also using PCR (Rüegg et al 2007, Jaffer et al 2009).…”

Section: Resultssupporting

confidence: 70%

“…The greater capacity of nested PCR for identifying naturally infected horses is due to the fact that this technique detects smallersized parasitemia (6x10 -6 % to 8x10 -6 %) than does conventional PCR (only down to 8x10 -5 %) (Bashiruddin et al 1999, Nicolaiwsky et al 2001, Baldani et al 2008. So far, only real-time PCR has been described as having sensitivity greater than or equal to nested PCR (Kim et al 2007).…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of PCR and multiplex PCR in relation to nested PCR for diagnosing Theileria equi

et al. 2011

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Section: Resultssupporting

confidence: 70%

Section: Resultsmentioning

confidence: 99%

Evaluation of PCR and multiplex PCR in relation to nested PCR for diagnosing Theileria equi

et al. 2011

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“…Sequencing of the SSU rDNA of this isolate (KO1) determined that it was similar to a Babesia parasite isolated from sheep in China (322). In Taiwan, Shih et al (518) discovered an asymptomatic infection with a species of Babesia in a 51-year-old woman.…”

Section: Babesia Sppmentioning

confidence: 99%

“…Examples include WA1, EU1, CA1, MO1, KO, and KY (35,114,322,574). However, based on molecular and immunological evidence, some of these acronyms are now known to represent the same species (114,574).…”

Section: Babesia Sppmentioning

confidence: 99%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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SUMMARY There are many neglected nonenteric protozoa able to cause serious morbidity and mortality in humans, particularly in the developing world. Diseases caused by certain protozoa are often more severe in the presence of HIV. While information regarding neglected tropical diseases caused by trypanosomatids and Plasmodium is abundant, these protozoa are often not a first consideration in Western countries where they are not endemic. As such, diagnostics may not be available in these regions. Due to global travel and immigration, this has become an increasing problem. Inversely, in certain parts of the world (particularly sub-Saharan Africa), the HIV problem is so severe that diseases like microsporidiosis and toxoplasmosis are common. In Western countries, due to the availability of highly active antiretroviral therapy (HAART), these diseases are infrequently encountered. While free-living amoebae are rarely encountered in a clinical setting, when infections do occur, they are often fatal. Rapid diagnosis and treatment are essential to the survival of patients infected with these organisms. This paper reviews information on the diagnosis and treatment of nonenteric protozoal diseases in immunocompromised people, with a focus on patients infected with HIV. The nonenteric microsporidia, some trypanosomatids, Toxoplasma spp., Neospora spp., some free-living amoebae, Plasmodium spp., and Babesia spp. are discussed.

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“…Babesia species are tick-borne haemoprotozoan parasites that infect virtually all mammalian species, with significant economic consequences in domestic animals and human health implications, particularly in the USA [52,53]. In mice, B. microti induces high but transient parasitaemias, which are quickly cleared (clearance beginning approximately 10 days after infection) [54].…”

Section: Materials and Methods (A) Methods Overviewmentioning

confidence: 99%

Infection before pregnancy affects immunity and response to social challenge in the next generation

Curno

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McElligott

et al. 2011

Phil. Trans. R. Soc. B

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Natural selection should favour parents that are able to adjust their offspring's life-history strategy and resource allocation in response to changing environmental and social conditions. Pathogens impose particularly strong and variable selective pressure on host life histories, and parental genes will benefit if offspring are appropriately primed to meet the immunological challenges ahead. Here, we investigated transgenerational immune priming by examining reproductive resource allocation by female mice in response to direct infection with Babesia microti prior to pregnancy. Female mice previously infected with B. microti gained more weight over pregnancy, and spent more time nursing their offspring. These offspring generated an accelerated response to B. microti as adults, clearing the infection sooner and losing less weight as a result of infection. They also showed an altered hormonal response to novel social environments, decreasing instead of increasing testosterone production upon social housing. These results suggest that a dominance-resistance trade-off can be mediated by cues from the previous generation. We suggest that strategic maternal investment in response to an infection leads to increased disease resistance in the following generation. Offspring from previously infected mothers downregulate investment in acquisition of social dominance, which in natural systems would reduce access to mating opportunities. In doing so, however, they avoid the reduced disease resistance associated with increased testosterone and dominance. The benefits of accelerated clearance of infection and reduced weight loss during infection may outweigh costs associated with reduced social dominance in an environment where the risk of disease is high.

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First Case of Human Babesiosis in Korea: Detection and Characterization of a Novel Type of Babesia sp. (KO1) Similar to Ovine Babesia

Cited by 106 publications

References 22 publications

Evaluation of PCR and multiplex PCR in relation to nested PCR for diagnosing Theileria equi

Evaluation of PCR and multiplex PCR in relation to nested PCR for diagnosing Theileria equi

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Infection before pregnancy affects immunity and response to social challenge in the next generation

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