First Canadian Case Report of Kidney Transplantation From an HIV-Positive Donor to an HIV-Positive Recipient

Ambaraghassi, Georges; Cardinal, Héloïse; Corsilli, Daniel; Fortin, Claude; Fortin, Marie-Chantal; Martel-Laferrière, Valérie; Malaise, Jacques; Paquet, Marie‐Eve; Rouleau, Danielle

doi:10.1177/2054358117695792

Cited by 15 publications

(12 citation statements)

References 17 publications

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“…Drawing on favourable experience in South Africa we have undertaken the first UK kidney transplants between HIV-infected individuals with excellent outcomes after 2 years of follow-up. Our results and others’ [ 5 ] demonstrate that kidney transplantation between carefully selected HIV-infected donors and recipients is a safe and effective treatment option with the potential to expand the organ donor pool for HIV-positive patients with end-stage kidney disease.…”

Section: Discussionsupporting

confidence: 68%

First UK case report of kidney transplantation from an HIV-infected deceased donor to two HIV-infected recipients

Nolan

Karydis

Drage

et al. 2017

Clinical Kidney Journal

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Kidney transplantation is now considered the treatment of choice for many human immunodeficiency virus (HIV)-infected patients with end-stage renal disease (ESRD). Graft survival rates using HIV-negative donors and carefully selected HIV-positive ESRD patients are similar to those observed in HIV-uninfected kidney transplant recipients. To address the relative shortfall in donated organs it has been proposed that organs from HIV-infected deceased donors might be allocated to HIV-infected patients on the transplant waiting list. Preliminary experience in South Africa reports promising short-term outcomes in a small number of HIV-infected recipients of kidney transplants from HIV-infected donors. We sought to replicate this experience in the UK by accepting kidney offers from HIV infected deceased donors for patients with HIV-infection on the kidney transplant waiting list. Here we report the UK’s first cases of kidney transplantation between HIV-positive donors and recipients.

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Section: Discussionsupporting

confidence: 68%

First UK case report of kidney transplantation from an HIV-infected deceased donor to two HIV-infected recipients

Nolan

Karydis

Drage

et al. 2017

Clinical Kidney Journal

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“…In 2015, Ambaragassi et al reported the first case of kidney transplantation from an HIV‐positive donor to an HIV‐positive recipient in Canada, showing an excellent outcome after 7 months of follow‐up, with good graft function and adequate control of HIV replication in the absence of opportunistic infections …”

Section: Discussionmentioning

confidence: 99%

“…These positive results, together with the chronic scarcity of available organs, have encouraged the idea of using organs from HIV‐positive donors for select HIV‐positive recipients, and the initial experiences seem to suggest promising short‐term outcomes …”

Section: Introductionmentioning

confidence: 99%

Kidney transplantation from an HIV‐positive cadaveric donor

Varotti

Dodi

Boscaneanu

et al. 2019

Transplant Infectious Dis

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Kidney transplantation is the gold‐standard therapy for select HIV‐positive patients with ESRD. Since the Italian Ministry of Health defined the guidelines for organ donation from HIV‐positive persons in 2018, we report the first case of renal transplantation from an HIV‐positive cadaveric donor in two HIV‐positive recipients in Italy. The donor was a 50‐year‐old male, deceased due to post‐anoxic encephalopathy, with a history of HIV infection in HAART, undetectable viral load, and HCV‐related chronic hepatitis that had been previously treated. The first recipient was a 59‐year‐old female with a prior history of drug addiction, and she suffered from ESRD secondary to HIV nephropathy. The patient followed preoperative HAART with a good viral response and undetectable HIV viral load. She also had a history of HCV‐related chronic hepatitis that had been successfully treated. The right kidney was uneventfully transplanted. The patient developed an asymptomatic reinfection of endogenous BK virus. The second recipient was a 41‐year‐old male with ESRD secondary to polycystic kidney disease. The patient was HIV‐positive in HAART, with a good viro‐immunologic response and an undetectable HIV viral load. He suffered from a severe form of hemophilia A and HCV‐related chronic hepatitis, which had been previously treated with undetectable HCV RNA. The left kidney was uneventfully transplanted. At the end of follow‐up, both patients had a healthy condition with stable renal function, a persistently good viral response and undetectable HIV and HCV viral loads. These encouraging preliminary results seem to confirm the safety and effectiveness of kidney transplantation from select HIV‐positive donors.

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“…Currently, there are no reports of kidney transplants from living donors who are hepatitis C virus (HCV) or human immunodeficiency virus (HIV) infected, only deceased donor cases. 77,78 Individuals infected with HCV have a high chance of cure following therapy with newer direct-acting antiviral therapy. 79,80 Certain Canadian transplant centers with access to these newer therapies are already accepting kidneys from deceased donors who are HCV positive to be transplanted into recipients who are HCV negative.…”

Section: Review Processmentioning

confidence: 99%

Canadian Society of Transplantation and Canadian Society of Nephrology Commentary on the 2017 KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors

Lam

Dipchand

Fortin

et al. 2020

Can J Kidney Health Dis

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Purpose of review: To review an international guideline on the evaluation and care of living kidney donors and provide a commentary on the applicability of the recommendations to the Canadian donor population. Sources of information: We reviewed the 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors and compared this guideline to the Canadian 2014 Kidney Paired Donation (KPD) Protocol for Participating Donors. Methods: A working group was formed consisting of members from the Canadian Society of Transplantation and the Canadian Society of Nephrology. Members were selected to have representation from across Canada and in various subspecialties related to living kidney donation, including nephrology, surgery, transplantation, pediatrics, and ethics. Key findings: Many of the KDIGO Guideline recommendations align with the KPD Protocol recommendations. Canadian researchers have contributed to much of the evidence on donor evaluation and outcomes used to support the KDIGO Guideline recommendations. Limitations: Certain outcomes and risk assessment tools have yet to be validated in the Canadian donor population. Implications: Living kidney donors should be counseled on the risks of postdonation outcomes given recent evidence, understanding the limitations of the literature with respect to its generalizability to the Canadian donor population.

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First Canadian Case Report of Kidney Transplantation From an HIV-Positive Donor to an HIV-Positive Recipient

Cited by 15 publications

References 17 publications

First UK case report of kidney transplantation from an HIV-infected deceased donor to two HIV-infected recipients

First UK case report of kidney transplantation from an HIV-infected deceased donor to two HIV-infected recipients

Kidney transplantation from an HIV‐positive cadaveric donor

Canadian Society of Transplantation and Canadian Society of Nephrology Commentary on the 2017 KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors

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