Fine needle aspiration cytology of salivary gland lesions: advantages and pitfalls

Kocjan, Gabrijela; Nayagam, M; Harris, Margaret

doi:10.1111/j.1365-2303.1990.tb00360.x

Cited by 55 publications

(49 citation statements)

References 14 publications

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“…This had occurred because one case of MEC was misdiagnosed as WT. The false positive rate has been reported to be low ( 0-10%) [2,15,16]. In our series, the false positive rate was 4.8 % and this was due to one case of Warthin's tumour, with extensive squamous metaplsia being diagnosed as MEC on FNAC.…”

Section: Methodsmentioning

confidence: 72%

“…Squamous cells and mucinous cells were interpreted as oncocytic cells and cyst discussiOn FNAC is a technique which is commonly used for the evaluation of both neoplastic and non neoplastic lesions which occur salivary gland [5][6][7]. The parotid gland was the commonly studied gland, followed by submandibular gland, a finding which has been well described in the literature [1][2][3][4][5][6][7][8][9].…”

Section: Methodsmentioning

confidence: 99%

“…In addition to the three main components, other elements that can be encountered in FNA smears of WT include, albeit rarely, metaplastic squamous and sebaceous gland cells. The differential diagnoses for WT are wide [2,4]. In most of the cases (>80%), the presence and combination of the three main cytologic elements can help in establishing the diagnosis without difficulty.…”

Section: Methodsmentioning

confidence: 99%

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Role of FNAC in the Preoperative Diagnosis of Salivary Gland Lesions

Fernandes

D'Souza

Khosla

et al. 2014

JCDR

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intrOductiOnSalivary gland swellings can result from tumours, an inflammatory process or cysts. It can sometimes be difficult to establish as to whether pathology arises from the salivary gland itself or from adjacent structures such as lymph nodes, soft tissues or skin. Fine Needle Aspiration Cytology (FNAC) is a widely used, safe and relatively nontraumatic procedure that can quickly provide important information. The main goal of doing FNAC of salivary gland lesions is to assist clinicians in the management of patients who present with mass lesions. The characteristic cytologic features of common salivary gland lesions have been well-delineated in literature [1]. However, there also exist cytologic pitfalls and overlapping features that make an accurate diagnosis difficult in few cases. This has led to a wide-range of sensitivities (62-97.6%) and specificities (94.3-100%) of cytologic diagnosis [2-5].The present study was designed to compare the cytologic findings of salivary gland lesions with their histologic diagnoses, in order to assess the sensitivity, specificity and diagnostic accuracy of FNAC, with an emphasis on discordant cases. MAteriAls And MethOdsThis study was performed on patients with suspected salivary gland swellings, who were referred for FNAC to the Department of Pathology of a medical college and hospital. This was done over a period of three years, on patients of either sex or any age, after obtaining written consents from them. Relevant clinical details were elicited in all the cases and findings of local examinations done were noted. All the patients underwent FNAC with use of a 23 G needle, with suction being provided by a 10 ml syringe. The characters of aspirates were noted, routine smears were prepared and they were stained with May-Grünwald's-Giemsa and Papanicoloau's stains. Pathology sectionThe cytologic interpretation was done as it has been described in standard textbooks of cytology. Histologic correlations were done wherever it was possible. A histologic diagnosis was considered as the gold standard for assessment of sensitivity and specificity of FNAC. A cyto-histologic correlation was done and appropriate statistical tests were applied.

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Section: Methodsmentioning

confidence: 72%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Role of FNAC in the Preoperative Diagnosis of Salivary Gland Lesions

Fernandes

D'Souza

Khosla

et al. 2014

JCDR

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“…9 In cases of malignancy like carcinoma ex pleomorphic adenoma chances of false negative are there as heterogenecity plays an important role in these tumours. 10 Studies done in past also reveal good sensitivity in cases of metastatic lesions as metastatic cells can easily be identified as compared to their other cell variants 11 . Various studies done in past have reported a diagnostic accuracy of 86-98% for cytological diagnosis of salivary gland neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological profile of salivary gland swellings in Kumaon region of Uttarakhand

Pant¹

2016

jmscr

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“…Interpretation of FNAC from the salivary glands is, however, a difficult cytopathological technique with many problems and pitfalls.9 10 Although some of these are similar to those encountered in the interpretation of histological material" and are due to the varied and heterogeneous nature of salivary gland neoplasia, other dilemmas are inherent to FNAC -namely, uncertainty as to the site and tissues actually aspirated, minimal material, and the lack of architectural pattern in smears compared with histological sections.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic problems in fine needle aspiration cytopathology of the salivary glands.

Young

1994

Journal of Clinical Pathology

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The most common problem is distinction between enlarged lymph nodes and sialomegaly. Lymph nodes are often enclosed within the parotid gland and it is not possible to differentiate intraparotid lymphadenopathy and true salivary gland enlargement by palpation alone. Similar dilemmas occasionally arise with perisalivary lymph nodes and the submandibular gland.An aspirate from a hyperplastic lymph node contains lymphocytes, follicle centre cells, and "tingible body" macrophages. If the needle also traverses salivary gland tissue then the resulting mixture of ductal or acinar cells plus cells of the lymphoid series may be difficult to distinguish from salivary gland disease associated with lymphocytosis. In the case of malignant disease, metastatic carcinoma especially of squamous cell or anaplastic type can be impossible to differentiate from primary salivary gland neoplasia as can nodal and extranodal non-Hodgkin's lymphomas.Some of the other lesions-for example, paraganglioma-are rarely encountered, but a branchial cleft cyst in the anterior parotid gland can be confused with cystic salivary gland disease, and a neurilemmoma with a pleomorphic adenoma.'6 18 Pilomatrixoma seems to be the skin adnexal tumour most

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Fine needle aspiration cytology of salivary gland lesions: advantages and pitfalls

Cited by 55 publications

References 14 publications

Role of FNAC in the Preoperative Diagnosis of Salivary Gland Lesions

Role of FNAC in the Preoperative Diagnosis of Salivary Gland Lesions

Clinicopathological profile of salivary gland swellings in Kumaon region of Uttarakhand

Diagnostic problems in fine needle aspiration cytopathology of the salivary glands.

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