Fine‐Needle Aspiration Cytology (FNAC) in Breast Cancer: A Reappraisal Based on Retrospective Review of 698 Cases

Kazi, Mufaddal; Suhani,; Parshad, Rajinder; Seenu, Vuthaluru; Mathur, Sandeep; Haresh, K.P.

doi:10.1007/s00268-017-3906-x

Cited by 26 publications

(29 citation statements)

References 32 publications

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“…According to the literature, it represents the first and most useful diagnostic tool in the evaluation of several body lesions. In fact, among the others, it has demonstrated interesting results in terms of diagnostic accuracy in head and neck cancer, breast carcinoma, and cervical carcinoma . To date, only 2 studies, from the same institution, have been published on the diagnostic utility of ultrasound with guided FNAC in the assessment metastatic lymph node disease in vulvar carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, among the others, it has demonstrated interesting results in terms of diagnostic accuracy in head and neck cancer, breast carcinoma, and cervical carcinoma. [10][11][12][13][14] To date, only 2 studies, from the same institution, have been published on the diagnostic utility of ultrasound with guided FNAC in the assessment metastatic lymph node disease in vulvar carcinoma. Moskovic et al, in their pilot study on 21 patients with early vulvar carcinoma using ultrasound and FNAC, confirmed an overall sensitivity of 83% and specificity of 82% for the detection of groin lymph node metastases.…”

Section: Discussionmentioning

confidence: 99%

“…It makes sense that a reliable tool in the evaluation of lymph nodes is represented by ultrasound combined with fine‐needle aspiration cytology (FNAC). This technique has demonstrated interesting results in terms of diagnostic accuracy in head and neck cancer, thyroid neoplasms, and breast, lung, and cervical carcinoma …”

Section: Introductionmentioning

confidence: 99%

“…This technique has demonstrated interesting results in terms of diagnostic accuracy in head and neck cancer, thyroid neoplasms, and breast, lung, and cervical carcinoma. [10][11][12][13][14] So far, only a few studies have investigated the diagnostic utility of ultrasound-guided FNAC of lymph nodes in the assessment of vulvar carcinoma, and the majority of them have had a prevalent focus on the radiological more than the cytological aspects of this examination. 15,16 In the current report, we evaluate the diagnostic accuracy of ultrasound-guided FNAC in our cohort of patients affected by vulvar carcinoma by comparing the reliability of cytological versus histological samples.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound‐guided FNA cytology of groin lymph nodes improves the management of squamous cell carcinoma of the vulva: Results from a comparative cytohistological study

Angelico

Santoro

Inzani

et al. 2019

Cancer Cytopathology

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Background Lymph node metastases represent the most important negative prognostic predictor in vulvar carcinoma. Therefore, an accurate preoperative assessment of suspicious lymph nodes would be fundamental for a personalized therapy. The aim of this article was to assess the reliability of ultrasound‐guided fine‐needle aspiration cytology (FNAC) in the preoperative assessment of nodal metastatic disease in 43 patients with vulvar cancer. Methods In total, 43 FNAC specimens of clinicoradiologically suspicious lymph nodes with corresponding nodal resection specimens were collected from 2016 to 2018 at Catholic University Hospital in Rome. Cytohistologic correlation was performed. Patients were treated with wide local excision of the vulvar mass followed by bilateral inguinofemoral lymphadenectomy and radiotherapy if the tumor involved a lymph node or the vulvar margins. Results Cytologic examination agreed with histology in 37 of 43 cases (86.04%). The authors observed a positive FNAC result in 14 of 20 histologically confirmed metastatic lymph nodes, 6 false‐negative cases, and no false‐positive results. The sensitivity and specificity of cytological examination were 76.92% and 100%, respectively. All patients with FNAC‐positive results showed metastatic disease in other surgically resected inguinofemoral nodes. Eleven of 29 patients (37.9%) with FNAC‐negative results also showed metastatic disease in subsequent lymphadenectomy specimens, but the extent of metastases was always <1 cm (range, 0.1‐0.6 cm). Conclusions FNAC of suspicious lymph nodes represents a useful tool in the management of patients with vulvar cancer. A positive result enables the surgeon to immediately perform a bilateral inguinofemoral lymphadenectomy thus avoiding an unnecessary sentinel lymph node sampling. Finally, FNAC can also predict the presence and extent of metastatic disease in other surgically resected inguinofemoral lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ultrasound‐guided FNA cytology of groin lymph nodes improves the management of squamous cell carcinoma of the vulva: Results from a comparative cytohistological study

Angelico

Santoro

Inzani

et al. 2019

Cancer Cytopathology

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“…The most common diagnosis using FNAC in the case of the breast is fibro-adenoma followed by fibrocystic disease, breast abscess, chronic inflammatory conditions and suspicious malignant masses [3]. 90-98% of sensitivity is achieved by using FNAC in clinically palpable breast lesions which gives a definitive diagnosis in 95% cases [5,6].…”

Section: Introductionmentioning

confidence: 99%

FNAC of Different Breast Lesions in Subset of Rural Areas of Sindh

Sidhwani

Mahesh

Chand³

et al. 2020

JAMMR

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Background:In the 1970's the introduction of Fine Need Aspiration Cytology (FNAC) proved to be the key method for examining the nature and malignant potential of many palpable lesions like thyroid, salivary glands and lymphadenopathies. Breast pathologies is one of the entity that can also be diagnosed with FNAC. Breast cancer is the most common malignancy of women with overall 100,000 cases being reported annually around the globe. The most frequent lesion encountered using FNAC in breast is fibro-adenoma followed by fibrocystic disease, breast abscess, chronic inflammatory conditions and suspicious malignant masses. In current cross sectional study we tried to find frequency of different breast lesions by FNAC. Methodology and Results: 649 samples were recruited from the Vital Laboratory Larkana with different pathological lesions of breast during the year 2014 and 2015 by non-probability Sidhwani et al.; JAMMR, 32(4): 10-15, 2020; Article no.JAMMR.55192 11 consecutive sampling. 613 (95%) were females and 32 (5%) were male with mean age of 30.812.8 years. Majority of case were of 20-39 years of age (55.8%). Most of the cases were diagnosed with benign lesions (329, 51%) followed by inflammatory lesions (132, 20.5%) and gynecomastia (15, 2.3%). Right breast was more affected (329, 51%). In present study we found a strong association of diagnosis with gender (p =0.000) and age (p =0.000). Conclusion: So in this study it is concluded that large number of females with breast pathologies present with benign lesions like fibro-adenoma at the age of 20-39 years. It is also concluded that in this age group mastitis and abscesses are common due to different risk factors. Original Research Article

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Accuracy of the International Academy of Cytology Yokohama system of breast cytology reporting for fine needle aspiration biopsy of the breast in a dedicated breast care setting

Agarwal

Singh

Mehan

et al. 2020

Diagnostic Cytopathology

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BackgroundThe International Academy of Cytology (IAC) Yokohama system is a recently proposed system for reporting breast cytology by fine needle aspiration biopsies (FNAB). Multiple studies are needed to confirm the risk of malignancy (ROM) of the various reporting categories of this system. The present article studies the accuracy of the IAC Yokohama system in our center.MethodsOver a period of 1 year (September 2018‐August 2019), all cases of breast masses assessed by FNAB and histological correlation were studied retrospectively. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) and overall accuracy of the IAC Yokohama system for diagnosing malignancy were assessed. The rates of malignancy (ROM) of each diagnostic category were also estimated.ResultsThree hundred and twenty‐one FNABs had cyto‐histological correlation. The percent sensitivity (with 95% Confidence Intervals) when the atypical, suspicious of malignancy and the malignant categories were regarded as positive for malignancy were 98.2% [95.5%, 99.5%], 96.0% [92.5%, 98.2%], and 86.7% [81.5%, 90.8%] respectively. The percent specificity (with 95% Confidence intervals) for the same categories in the same order were 59.5% [47.4%, 70.7%], 91.9% [83.2%, 97.0%], and 100% [95.1%, 100%] respectively. The area under curve (AUC) for diagnosing malignancy was 0.981[0.963, 0.993]. The ROM for the benign, atypical, suspicious of malignancy and malignant category were 8.3% [2.3%, 20.0%], 17.2% [5.8%, 35.8%], 77.8% [57.7%, 91.4%], and 100% [98.1%, 100%] respectively.ConclusionThe IAC Yokohama system is suitable for accurately reporting breast lesions on FNAB.

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Fine‐Needle Aspiration Cytology (FNAC) in Breast Cancer: A Reappraisal Based on Retrospective Review of 698 Cases

Abstract: FNAC is a reliable tool for diagnosing cancer in suspicious breast lesions with a good sensitivity and PPV in hands of an experienced cytopathologist. Surgical treatment may be safely undertaken based on FNAC particularly in early operable breast cancers suitable for breast conservation.

Cited by 26 publications

References 32 publications

Ultrasound‐guided FNA cytology of groin lymph nodes improves the management of squamous cell carcinoma of the vulva: Results from a comparative cytohistological study

Ultrasound‐guided FNA cytology of groin lymph nodes improves the management of squamous cell carcinoma of the vulva: Results from a comparative cytohistological study

FNAC of Different Breast Lesions in Subset of Rural Areas of Sindh

Accuracy of the International Academy of Cytology Yokohama system of breast cytology reporting for fine needle aspiration biopsy of the breast in a dedicated breast care setting

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