Fine-needle Aspiration Biopsy of Suspected Intraocular Tumors

Shields, Jerry A.; Shields, Carol L.; Ehya, Hormoz; Eagle, Ralph C.; Potter, Patrick De

doi:10.1016/s0161-6420(93)31418-1

Cited by 270 publications

(157 citation statements)

References 11 publications

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“…This is much higher than found by Shields et al (1993), who performed FNAB only in 2.5% of patients with suspected intraocular tumours. Many ophthalmologists accept a FNAB only in cases with a severe uncertainty of the diagnosis of intraocular lesions (Augsburger et al 1985).…”

Section: Discussionmentioning

confidence: 53%

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Fine needle aspiration biopsy in selecting treatment for inconclusive intraocular disease

Eide

Syrdalen

Walaas

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To evaluate the fine needle aspiration biopsy (FNAB) as a diagnostic tool in cases where it was impossible to make a definitive diagnosis with noninvasive techniques. Method: 80 consecutive patients with inconclusive diagnoses were examined by FNAB prior to decision of treatment. Biopsies were performed through a transscleral route in 50 eyes, an anterior chamber route in 16 eyes and a transvitreal approach in 14 eyes. The consequences of FNAB were analysed retrospectively. Results: FNAB confirmed malignancy in 59 eyes. Inconclusive material was obtained from 5 eyes judged clinically to be malignant disorders. One melanoma was misinterpreted as being a metastasis. In 47.5% of our patients this procedure altered the therapeutic plan and 25 patients were spared enucleation. The biopsy material was correctly diagnosed as benign in 16 cases. Conclusion: In eyes where the diagnosis remained uncertain after non-invasive tests, FNAB gave important information which greatly influenced our choice of treatment. FNAB contained sufficient tissue elements for cytological diagnosis in 77 eyes. Cytopathological interpretation failed once in relation to tumour type. The procedure of FNAB can be recommended for use in ambiguous tumour cases of the eye. Probably it should only be used in tumour centres with adequate cytology service.

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Section: Discussionmentioning

confidence: 53%

“…Clinical diagnosis of intraocular lesions by non-invasive methods is in general highly accurate (Shields et al 1993). The diagnostic accuracy of 99.6% verified histopathologically in the COMS study of medium sized melanomas is impressive (1990).…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration biopsy in selecting treatment for inconclusive intraocular disease

Eide

Syrdalen

Walaas

et al. 1999

Acta Ophthalmologica Scandinavica

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“…Tissue collection is safe via both vitreous tap and vitrectomy, although the latter is preferred because cellular yields are higher and less vitreoretinal traction is exerted. 12, 13 Char et al 14 showed a greater loss of cellular detail with vitrectomy than vitreous tap. However, it was unclear if this was due to the cutting instrument or the duration spent in the cassette in basic salt solution (BSS).…”

Section: Discussionmentioning

confidence: 99%

Cytopathological analysis of vitreous in intraocular lymphoma

Intzedy

Teoh

Hogan

et al. 2007

Eye

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Objective To describe the cytopathological method used in the analysis of vitreous samples in the diagnosis of primary intraocular lymphoma (PIOL). Participants Seven patients with refractory posterior uveitis referred to a regional ocular inflammatory service were diagnosed as having PIOL between 1999 and 2006. Methods Clinical features of the uveitis and cytopathological preparation of the samples were described. All patients underwent vitrectomy and samples were placed in formal saline or prepared fresh. Following paraffin embedding generating a cell block, immunostaining, and polymerase chain reactions were performed. Results Five women (71.4%) and two men (28.6%) (mean age 67.7 years) were included. Five patients had diagnostic vitrectomy performed within 6 months of presentation, but in two patients diagnosis was delayed up to 2 years. Uveitis was bilateral in two patients. Cytologic and immunohistochemical staining prepared from the vitreous specimens showed PIOL in all patients, and PCR displayed single band of immunoglobulin heavy chain rearrangement in five out of six samples tested. Conclusions Diagnosis of PIOL is difficult due to small volume of sample with low number of malignant cells and inadequate preparation of samples. Our method of analysis with fresh samples together with immunohistochemistry and PCR analysis demonstrates a high yield of diagnosis reducing diagnostic delay.

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“…If the diagnosis cannot be established with non-invasive tests, fineneedle aspiration biopsy (FNAB) is the most useful diagnostic tool (Char 1989), and is regarded as safe and reliable (Augsburger et al 1985;Shields et al 1993). In certain cases of disseminated cancer diseases, locating the primary tumour site can have important therapeutical consequences.…”

Section: Iagnosis Of a Uveal Tumour Ismentioning

confidence: 99%

Fine‐needle aspiration biopsy diagnosis of a uveal metastasis from a follicular thyroid carcinoma

Ritland

Eide

Walaas

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To report a rare tumour of the eye, and to illustrate the importance of performing a fine-needle aspiration biopsy. Case report: An 80-year-old woman suffering from general malaise, dyspnea and abdominal pain was found to have multiple lung metastases, a large tumour in the upper part of the mediastinum, and a large orange-brown tumour (19¿15¿11 mm) situated nasally in the left eye. Fine-needle aspiration biopsy of the uveal tumour and of the goitre was performed. Cytological examination from the two sites disclosed cells compatible with a follicular thyroid carcinoma of oxyfil cell-type. Results: The patient underwent a total thyroidectomy and has so far had 2 series of 131 I therapy. Additionally, the eye tumour was treated locally with a 125 I plaque, and three months later the tumour thickness had decreased from 11.0 to 6.4 mm. Best-corrected visual acuity is still unchanged. The patient's general state improved as her dyspnea decreased significantly. Conclusion:The treatment has improved the patient's quality of life, and probably prolonged her life expectancy. Fine-needle aspiration biopsy was necessary to establish the diagnosis.

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Fine-needle Aspiration Biopsy of Suspected Intraocular Tumors

Cited by 270 publications

References 11 publications

Fine needle aspiration biopsy in selecting treatment for inconclusive intraocular disease

Fine needle aspiration biopsy in selecting treatment for inconclusive intraocular disease

Cytopathological analysis of vitreous in intraocular lymphoma

Fine‐needle aspiration biopsy diagnosis of a uveal metastasis from a follicular thyroid carcinoma

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