Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study

Abstract

FLG null mutations were significantly associated with hand eczema (< 12 months) in subjects with atopic dermatitis. Combined atopic dermatitis and filaggrin null mutation status was strongly associated with early onset of hand eczema and hand eczema persistence.

Filaggrin Gene Defects and Dry Skin Barrier Function

“…Several studies have investigated whether certain fi laggrin variants might be associated with CHE in general. Some also investigated certain CHE subtypes [ 4,9,12,14,26 ] . Probably the most convincing evaluation of the possible association between hand eczema and fi laggrin null mutations was provided by a recent general population study including 3,471 adults.…”

“…Probably the most convincing evaluation of the possible association between hand eczema and fi laggrin null mutations was provided by a recent general population study including 3,471 adults. It showed that subjects with atopic dermatitis and fi laggrin null mutation status had a signifi cantly higher prevalence of hand eczema, as well as earlier onset of disease and higher persistence of disease when compared with subjects who did not report atopic dermatitis and who had wild-type fi laggrin status [ 26 ] . Carlsen et al found no association between, respectively, nickel allergy, polysensitization, hand eczema at fi rst appearance or occurrence of dermatitis, and fi laggrin null mutations [ 4 ] .…”

Contact hypersensitivity to nickel in patients with atopic dermatitis

“…Częstość występowania ACD u pacjentów z wypryskiem atopowym wynosi 13,6-27,4% i jest istotnie większa u kobiet [39]. Najczęstszymi alergenami były metale, głównie nikiel, rzadziej substancje zapachowe [39] i podłoża leków stosowanych miejscowo [40]. Wyprysk kontaktowy alergiczny, prowokowany głównie przez substancje zapachowe, chrom, nikiel i lanolinę, obserwowano u 14,9-64,2% dzieci chorych na AD [41][42][43][44].…”

“…Allergic contact dermatitis prevalence in patients with atopic eczema was estimated at 13.6-27.4% and it was significantly higher in women [39]. Metals (especially nickel) and to a lesser extent flavorings [39] and bases of locally administered drugs were the most common allergens [40]. Allergic contact dermatitis provoked mainly by flavorings, chromium, nickel and lanolin was reported in 14.9-64.2% of the investigated pediatric population with AD [41][42][43][44].…”

Contact Allergy in Atopic Patients: What We Suspected and What We Know

“…Recently, the key role of filaggrin (FLG) proteins in maintaining an effective skin barrier against the external environment has been demonstrated [20]. A positive association between FLG mutations and contact sensitivity (CS) to nickel was found among German adults [21], but could only be confirmed in Danish adults without ear piercings [22]. Furthermore, FLG mutation carriers reported ACD to nickel at a significantly younger age than controls with normal filaggrin, and they also displayed stronger patch test reactivity [23].…”