Field study of Microcystic Adnexal Carcinoma. Field study of Microcystic Adnexal Carcinoma in Japan.

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

“…Review of the literature identified 92 patients fulfilling the inclusion criteria for this study in addition to our current patient, for a total of 93 patients with MAC. 2,3,5,8,9,11–69 Patient demographics and presenting characteristics are summarized in Table 1.…”

“…Of patients with available information, most tumors presented as brown-to-reddish (5/18, 28%) 32,54,57,59,62 or pearly white-to-waxy (7/18, 39%) 8,24,33,40,52,58,68 nodules (37/68, 54%) 2,3,5,9,11,14–16,19,23–26,32,33,35,37,43,46,48,52,54,56,59,66,67,69 or plaques (20/68, 29%) 8,13,17,18,21,22,24,28,29,42,47,54,58,59,61–63,68 that were ill-defined, sclerotic, or indurated (20/51, 39%) 3,13,25,26,32,33,42,46,47,56,57,59,62,63,68 with firm consistency (19/51, 37%), 2,8,13,23,24,28,36,37,47,54,56,68 10 mm or greater in size (33/46, 72%). 3,6,11,13,14,17,18,24,25,29,35,37,42,47,49,51,52,…”

“…There was no appreciable side predilection (right, 41/77, 53% vs. left, 36/77, 47%). Eighty-six of 93 (92%) tumors originated in the periocular skin, most commonly in the eyebrow (26/86, 30%) [12][13][14]17,18,20,22,23,[25][26][27]29,30,36,37,43,47,48,53,[59][60][61]67 followed by the lower eyelid (20/86, 23%). 2,8,11,13,32,33,35,39,40,49,54,56,58,59,62 Fifteen of 86 (17%) tumors involved more than 1 region.…”

“…Of patients with available information, most tumors presented as brown-to-reddish (5/18, 28%) 32,54,57,59,62 or pearly white-to-waxy (7/18, 39%) 8,24,33,40,52,58,68 nodules (37/68, 54%) 2,3,5,9,11,[14][15][16]19,[23][24][25][26]32,33,35,37,43,46,48,52,54,56,59,66,67,69 or plaques (20/68, 29%) 8,13,17,18,21,22,24,28,29,42,47,54,58,…”

“…Thirty-four of 87 (39%) patients with available follow-up required additional intervention for tumor recurrence (33/87, 38%) and persistent symptomatic widespread disease (our patient, 1/87, 1%). Additional interventions included simple re-excision (11/34, 32%) 2,5,11,15,24,29,40,57,66 with positive margins in 4 of 11 (36%) 5,24,66 of these cases and excision with frozen section clearance of margins (3/34, 9%). 2,5,40 Mohs micrographic surgery was performed in 13 of 34 (38%) 3,5,8,13,14,21,24,45,46,49 patients with known information.…”