Fibrous Histiocytoma of the Corneosclera

The epidemiology, clinical characteristics, histopathology and management of juvenile- and adult-onset corneoscleral limbus xanthogranuloma

“…Extensive xanthogranulomatous inflammation at the limbus can infiltrate the cornea, resulting in complete destruction of the stromal architecture, with focal infiltration into the overlying epithelium [17]. The differential diagnosis of limbal lesions comprises dermoid, lipodermoid, pterygium, pyogenic granuloma, foreign body granuloma, nodular fasciitis, primary xanthoma, histiocytoma, lymphoproliferative lesions, and neoplasia [4,11,[27][28][29][30][31]. The majority of these conditions can be ruled out on the basis of the patient's age at presentation, the clinical history and the appearance of such limbal growths [1].…”

The epidemiology, clinical characteristics, histopathology and management of juvenile- and adult-onset corneoscleral limbus xanthogranuloma

“…Extensive xanthogranulomatous inflammation at the limbus can infiltrate the cornea, resulting in complete destruction of the stromal architecture, with focal infiltration into the overlying epithelium [17]. The differential diagnosis of limbal lesions comprises dermoid, lipodermoid, pterygium, pyogenic granuloma, foreign body granuloma, nodular fasciitis, primary xanthoma, histiocytoma, lymphoproliferative lesions, and neoplasia [4,11,[27][28][29][30][31]. The majority of these conditions can be ruled out on the basis of the patient's age at presentation, the clinical history and the appearance of such limbal growths [1].…”

Successful treatment of recurrent benign fibrous histiocytoma by complete surgical removal and appropriate ocular surface reconstruction

“…[ 8 ] A definitive diagnosis is confirmed by histopathologic evaluation, which morphologically shows a storiform pattern composed of short, twisting fascicles of cells [ 4 , 15 ] Unlike malignant fibrous histiocytomas, no cellular atypia, nuclear pleomorphism or mitotic activity is observed in benign cases. [ 5 ] However, benign fibrous histiocytoma can show an infiltrative growth pattern and local recurrence, similar to malignant fibrous histiocytoma. [ 13 ] The recurrent lesions can appear within a few weeks after a conservative resection and grow rapidly.…”

The epidemiology, clinical characteristics, histopathology and management of juvenile- and adult-onset corneoscleral limbus xanthogranuloma

“…Extensive xanthogranulomatous inflammation at the limbus can infiltrate the cornea, resulting in complete destruction of the stromal architecture, with focal infiltration into the overlying epithelium [17]. The differential diagnosis of limbal lesions comprises dermoid, lipodermoid, pterygium, pyogenic granuloma, foreign body granuloma, nodular fasciitis, primary xanthoma, histiocytoma, lymphoproliferative lesions, and neoplasia [4,11,[27][28][29][30][31]. The majority of these conditions can be ruled out on the basis of the patient's age at presentation, the clinical history and the appearance of such limbal growths [1].…”

Successful treatment of recurrent benign fibrous histiocytoma by complete surgical removal and appropriate ocular surface reconstruction

“…[ 8 ] A definitive diagnosis is confirmed by histopathologic evaluation, which morphologically shows a storiform pattern composed of short, twisting fascicles of cells [ 4 , 15 ] Unlike malignant fibrous histiocytomas, no cellular atypia, nuclear pleomorphism or mitotic activity is observed in benign cases. [ 5 ] However, benign fibrous histiocytoma can show an infiltrative growth pattern and local recurrence, similar to malignant fibrous histiocytoma. [ 13 ] The recurrent lesions can appear within a few weeks after a conservative resection and grow rapidly.…”

The epidemiology, clinical characteristics, histopathology and management of juvenile- and adult-onset corneoscleral limbus xanthogranuloma

“…Extensive xanthogranulomatous inflammation at the limbus can infiltrate the cornea, resulting in complete destruction of the stromal architecture, with focal infiltration into the overlying epithelium [17]. The differential diagnosis of limbal lesions comprises dermoid, lipodermoid, pterygium, pyogenic granuloma, foreign body granuloma, nodular fasciitis, primary xanthoma, histiocytoma, lymphoproliferative lesions, and neoplasia [4,11,[27][28][29][30][31]. The majority of these conditions can be ruled out on the basis of the patient's age at presentation, the clinical history and the appearance of such limbal growths [1].…”

Successful treatment of recurrent benign fibrous histiocytoma by complete surgical removal and appropriate ocular surface reconstruction

“…[ 8 ] A definitive diagnosis is confirmed by histopathologic evaluation, which morphologically shows a storiform pattern composed of short, twisting fascicles of cells [ 4 , 15 ] Unlike malignant fibrous histiocytomas, no cellular atypia, nuclear pleomorphism or mitotic activity is observed in benign cases. [ 5 ] However, benign fibrous histiocytoma can show an infiltrative growth pattern and local recurrence, similar to malignant fibrous histiocytoma. [ 13 ] The recurrent lesions can appear within a few weeks after a conservative resection and grow rapidly.…”