Rocío G. Sampayo, Andrés M. Toscani, Matthew G. Rubashkin, Kate Thi, Luciano A. Masullo, Ianina L. Violi, Jonathon N. Lakins, Alfredo Cáceres, William C. Hines, Federico Coluccio Leskow, Fernando D. Stefani, Dante R. Chialvo, Mina J. Bissell, Valerie M. Weaver et al.
Abstract:Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression. Therefore, understanding what activates ERα is critical for cancer treatment in particular and cell biology in general. Using biochemical approaches and superresolution microscopy, we show that estrogen drives membrane ERα into endosomes in breast cancer cells and that its fate is determined by the presence of fibronectin (FN) in the extracellular matrix; it …
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