Fibromyalgia and Irritable Bowel Syndrome in Female Pelvic Pain

Johnson, Claire M.; Makai, G.

doi:10.1055/s-0038-1676090

Cited by 20 publications

(14 citation statements)

References 66 publications

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“…There is no pathological cause of FMS [ 28 ]. Recent study with functional neuroimaging has consistently demonstrated altered central pain perception in the brain of patients with FMS [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation

Yang

Wei

et al. 2020

Mol Brain

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Temporomandibular disorder (TMD) is commonly comorbid with fibromyalgia syndrome (FMS). The incidence of these pain conditions is prevalent in women and prone to mental stress. Chronic pain symptoms in patients with FMS and myofascial TMD (mTMD) are severe and debilitating. In the present study, we developed a new animal model to mimic the comorbidity of TMD and FMS. In ovariectomized female rats, repeated forced swim (FS) stress induced mechanical allodynia and thermal hyperalgesia in the hindpaws of the 17β-estradiol (E2) treated rats with orofacial inflammation. Subcutaneous injection of E2, injection of complete Freund’s adjuvant (CFA) into masseter muscles or FS alone did not induce somatic hyperalgesia. We also found that the somatic hyperalgesia was accompanied by upregulation of GluN1 receptor and serotonin (5-hydroxytryptamine, 5-HT) 3A receptor expression in the dorsal horn of spinal cord at L4-L5 segments. Intrathecal injection of N-methyl-D-aspartic acid receptor (NMDAR) antagonist 2-amino-5-phosphonovaleric acid (APV) or 5-HT 3 receptor antagonist Y-25130 blocked stress-induced wide-spreading hyperalgesia. These results suggest that NMDAR-dependent central sensitization in the spinal dorsal horn and 5-HT-dependent descending facilitation contribute to the development of wide-spreading hyperalgesia in this comorbid pain model.

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Section: Discussionmentioning

confidence: 99%

Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation

Yang

Wei

et al. 2020

Mol Brain

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“…The relationship between gynecological disorders and IBS is well known and has been extensively studied in the literature [16][17][18][19][20], and unjustiied pelvic surgery has even been reported in patients with IBS [21]. A recent primary care registry study on over 13,000 subjects with IBS conirmed a clear association with urogenital symptoms and infections [22].…”

Section: Discussionmentioning

confidence: 99%

Gynecological Disorders in Patients with Non-celiac Wheat Sensitivity

Soresi

Incandela²,

Mansueto

et al. 2020

Dig Dis Sci

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“…These diagnoses were chosen because they are common comorbid conditions in women with pelvic floor disorders and are considered by many to represent disorders attributable to central sensitization. 8,[15][16][17][18] Women in the nonpain group were women without any of these conditions. Demographic information collected included age, geographic location, and insurance status (eg, private commercial only, Medicare plus private commercial supplemental).…”

Section: Methodsmentioning

confidence: 99%

Midurethral Sling Removal or Revision in Women with Chronic Pain

Rockefeller

Petersen

Jeppson

et al. 2022

Female Pelvic Med Reconstr Surg

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Objectives:The objectives of this study are (1) to estimate the incidence of midurethral sling revision/removal in women with preexisting pain diagnoses versus those without these diagnoses and (2) to describe associations between numbers and type of pain diagnoses with revision/removal.Methods: Women who underwent midurethral sling surgery between 2009 through 2014 were identified in the MarketScan database and tracked and December 31, 2014. Patients with preoperative chronic pain diagnoses (fibromyalgia, endometriosis, irritable bowel, dyspareunia, low back pain, temporomandibular joint syndrome, interstitial cystitis, pelvic/perineal pain) were compared with controls (those without these diagnoses) regarding mesh sling revision/removal. Logistic regression identified variables associated with mesh revision/removal, and survival analysis compared timing of mesh removal/revision.Results: There were 161,459 women who underwent midurethral sling surgery (pain, 83,484; nonpain, 77,975). Pain and nonpain groups differed in age (52.1 vs 53.5 years, P < 0.01) and insurance status ( P < 0.01), with the pain group more commonly living in the South or West. Mean follow-up was 42.3 months. Cumulative risk for sling revision/removal was higher in patients with 1 pain diagnosis relative to controls (relative risk, 1.54; 95% confidence interval [CI], 1.41-1.54). Risks increased with increased pain diagnoses (≥4 diagnoses; relative risk, 3.13; 95% CI, 2.81-3.47). Pelvic pain conditions had greatest odds of mesh revision/removal (dyspareunia adjusted odds ratio [aOR], 2.44; 95% CI, 2.23-2.63; interstitial cystitis aOR, 1.46; 95% CI, 1.27-1.66; pelvic/perineal pain aOR, 1.41; 95% CI, 1.33-1.48). Co-occurrence of dyspareunia and interstitial cystitis or pelvic/ perineal pain had 12.7% cumulative incidence of sling revision/removal. Cox proportional hazards revealed greatest risk for those with pelvic pain conditions (hazard ratio, 2.40; 95% CI, 2.13-2.70).Conclusions: Chronic pain diagnoses increased risk of midurethral sling revision/removal; pelvic pain and numbers of diagnoses increased this risk.

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Fibromyalgia and Irritable Bowel Syndrome in Female Pelvic Pain

Cited by 20 publications

References 66 publications

Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation

Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation

Gynecological Disorders in Patients with Non-celiac Wheat Sensitivity

Midurethral Sling Removal or Revision in Women with Chronic Pain

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