Fibroid growth and medical options for treatment

Modern Myoma Treatment in the Last 20 Years: A Review of the Literature

“…After the introduction of ulipristal acetate, the use of Gn-RH-analogs for the treatment of symptomatic fibroids, particularly the control of significant bleeding due to fibroids, has almost completely disappeared. Clearly, the known disadvantages of Gn-RH-analogs, that is, the severe postmenopausal-like side effects as well as the known negative effect on subsequent surgery, have led to a swift change in real life medical practice [ 14 ].…”

Modern Myoma Treatment in the Last 20 Years: A Review of the Literature

“…After the introduction of ulipristal acetate, the use of Gn-RH-analogs for the treatment of symptomatic fibroids, particularly the control of significant bleeding due to fibroids, has almost completely disappeared. Clearly, the known disadvantages of Gn-RH-analogs, that is, the severe postmenopausal-like side effects as well as the known negative effect on subsequent surgery, have led to a swift change in real life medical practice [ 14 ].…”

Acupuncture in Uterine Fibroids Management: Literature Update on Frequently Used Acupoints and the Underlying Mechanism—A Narrative Review

“…Uterine fibroid development is influenced by complex feedback mechanisms between sex hormones (estradiol and progesterone) and growth factors, with a higher incidence in women with elevated levels of these hormones [ 11 , 29 , 67 ]. Existing therapies focus on modulating estradiol and progesterone synthesis or action [ 9 ]. Literature reviews indicate that acupuncture can regulate these hormones [ 62 ].…”

The Potential of Transforming Growth Factor-beta Inhibitor and Vascular Endothelial Growth Factor Inhibitor as Therapeutic Agents for Uterine Leiomyoma

“…Treatment with gonadotropin-releasing hormone analogs leads to a rebound in fibroid growth and the loss of bone mineral density when the administration is stopped [16]. As another option, a selective progesterone receptor modulator with a tissue-specific effect on the progesterone receptor can be used [17]. Mifepristone is the first progesterone receptor antagonist and has been used clinically for more than 25 years [18,19].…”

Modern Myoma Treatment in the Last 20 Years: A Review of the Literature

“…After the introduction of ulipristal acetate, the use of Gn-RH-analogs for the treatment of symptomatic fibroids, particularly the control of significant bleeding due to fibroids, has almost completely disappeared. Clearly, the known disadvantages of Gn-RH-analogs, that is, the severe postmenopausal-like side effects as well as the known negative effect on subsequent surgery, have led to a swift change in real life medical practice [ 14 ].…”

Acupuncture in Uterine Fibroids Management: Literature Update on Frequently Used Acupoints and the Underlying Mechanism—A Narrative Review

“…Uterine fibroid development is influenced by complex feedback mechanisms between sex hormones (estradiol and progesterone) and growth factors, with a higher incidence in women with elevated levels of these hormones [ 11 , 29 , 67 ]. Existing therapies focus on modulating estradiol and progesterone synthesis or action [ 9 ]. Literature reviews indicate that acupuncture can regulate these hormones [ 62 ].…”

The Potential of Transforming Growth Factor-beta Inhibitor and Vascular Endothelial Growth Factor Inhibitor as Therapeutic Agents for Uterine Leiomyoma

“…Treatment with gonadotropin-releasing hormone analogs leads to a rebound in fibroid growth and the loss of bone mineral density when the administration is stopped [16]. As another option, a selective progesterone receptor modulator with a tissue-specific effect on the progesterone receptor can be used [17]. Mifepristone is the first progesterone receptor antagonist and has been used clinically for more than 25 years [18,19].…”

Modern Myoma Treatment in the Last 20 Years: A Review of the Literature

“…After the introduction of ulipristal acetate, the use of Gn-RH-analogs for the treatment of symptomatic fibroids, particularly the control of significant bleeding due to fibroids, has almost completely disappeared. Clearly, the known disadvantages of Gn-RH-analogs, that is, the severe postmenopausal-like side effects as well as the known negative effect on subsequent surgery, have led to a swift change in real life medical practice [ 14 ].…”

Acupuncture in Uterine Fibroids Management: Literature Update on Frequently Used Acupoints and the Underlying Mechanism—A Narrative Review

“…Uterine fibroid development is influenced by complex feedback mechanisms between sex hormones (estradiol and progesterone) and growth factors, with a higher incidence in women with elevated levels of these hormones [ 11 , 29 , 67 ]. Existing therapies focus on modulating estradiol and progesterone synthesis or action [ 9 ]. Literature reviews indicate that acupuncture can regulate these hormones [ 62 ].…”

The Potential of Transforming Growth Factor-beta Inhibitor and Vascular Endothelial Growth Factor Inhibitor as Therapeutic Agents for Uterine Leiomyoma

“…Treatment with gonadotropin-releasing hormone analogs leads to a rebound in fibroid growth and the loss of bone mineral density when the administration is stopped [16]. As another option, a selective progesterone receptor modulator with a tissue-specific effect on the progesterone receptor can be used [17]. Mifepristone is the first progesterone receptor antagonist and has been used clinically for more than 25 years [18,19].…”