Fibroepithelioma of Pinkus (FeP) Located in the Left Lower Quadrant of the Abdomen - Case Report and Review of the Literature

Abstract

BACKGROUNDFibroepithelioma of Pinkus (FeP) is an uncommon and controversial skin lesion, sharing features of both basal cell carcinoma (BCC) and trichoepithelioma. In this article, we present a case of FeP and synthesise current concepts on the etiopathogenesis, diagnosis and treatment of this uncommon tumour.CASE REPORTWe report the case of an 88-year-old male patient presenting to the dermatology clinic for a sharply demarcated, pink, exophytic cutaneous tumour situated in the left inguinal region. The histopathological examination performed after complete surgical excision of the lesion revealed a diagnosis of FeP. A systematic review of the literature was conducted. The terms `fibroepithelioma` and `Pinkus` have been searched in bibliographical databases, including PubMed and Google Scholar, without time limitation up to February 15th, 2017. Seventy-nine articles that fulfilled all the required conditions were identified. Relevant citations and additional articles identified from references have been assessed. The systematic review included a total number of 452 cases of FeP.CONCLUSIONEven though FeP is considered a relatively rare tumour, its true incidence rate might be higher than previously believed. The clinical aspects of the lesion described in this paper and its location in the left lower quadrant of the abdomen are classic features of FeP. Histopathologic examination revealed features of both BCC and trichoepithelioma. Further epidemiological studies are required to clarify whether patients with FEP should be screened for the occurrence of other malignancies.

Basal cell carcinoma in situ of the skin revisited: case reports of the superficial type and fibroepithelioma type of this in situ cutaneous neoplasm

“…Squamous cell carcinoma and malignant melanoma are cutaneous malignancies that usually develop from in situ neoplasms (Table 1), [37][38][39][40][41][42][43][44][45][46][47][48].…”

“…Merkel cell carcinoma also has an in situ precursor that less commonly has been observed (Table 1), [37][38][39][40][41][42][43][44][45][46][47][48]. Recently, a case series of three men with proposed cutaneous basal cell carcinoma in situ has been described [32].…”

“…It clinically presents as a nodular lesion often on the back. Microscopic examination shows strands of basaloid tumor cells-that are contiguous with the overlying epithelium-that extend from the epidermis into the dermis [44][45][46][47][48].…”