Fibroblast Development and Fibrogenesis

Cutaneous Mucinosis in a Child with Systemic Lupus Erythematosus

“…It is interesting to speculate that both the eruption of mucinous paptiles in our patient and the eruption of dermatofibromas in previously reported patients can be traced to dysfutictional fibrobiasts. Under normal conditions, fibrobiasts produce collagen precursors and nonsulfated acid mucopolysaccharides (29). In pathologic states, the fibrobiasts may be commatided by some circulating messenger either to overproduce acid mucopolysaccharides, resulting in mucinosis, or alternatively, to overproduce collagen, resulting in lesions sucb as dermatofibromas.…”

Ultrastructure of the normal atrial endocardium.

“…Fibroblasts exhibit variable morphology (Chapman, 1962;Moore and Shoenberg, 1960), and this variation may be related to their activity (Peach, Williams, and Chapman, 1961;Zelickson, 1963). Difficulty in distinguishing fibroblasts from histiocytes has been experienced by Chapman (1961) and from undifferentiated cells by Movat and Fernando (1962).…”

“…The ill-defined cell membrane of fibroblasts in some cases may be due to the close contact of cell membrane to developing collagen filaments, a picture similar to the " marginal condensation" described by Yardley et al (1960), but in other instances the ill-defined membrane seemed to be genuine and due to absence of the membrane at some areas. It is thought that cell wall disruption is a method by which fibroblasts shed their collagen units, among other substances, into the extracellular spaces (Chapman, 1961;Zelickson, 1963). SUMMARY The ultrastructure of the normal atrial endocardium is described.…”

Prostaglandins in Normal and Pathological Skin

“…The fibroblasts synthesize and release into the extracellular space the collagen precursor tropocollagen. On the outer surface of cultivated fibroblasts the polymerization of eollagen fibrils by aggregation of tropocollagen particles can be observed (Zeliekson 1963). Kiseher (1967) has reported that PGE, and PGB, stimtilate eollagen morphogenesis in organ cultures of developing chick skin.…”