Fibrinolytic responses of human peritoneal fluid in laparoscopic cholecystectomy: a prospective clinical study

Tarhan, Ömer Rıdvan; Barut, İbrahim; Akdeniz, Yusuf; Sütçü, Recep; Çerçi, Celal; Bülbül, Mahmut

doi:10.1007/s00464-007-9566-4

Cited by 8 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the light of our own results and contrary to common opinion, it can be concluded that peritonitis does not inhibit intraperitoneal fibrinolytic activity. The existence of intraperitoneal fibrinolysis has been confirmed in observations by Tarhan et al, however, the authors showed the presence of another plasminogen activator, t-PA [11]. Similarly to our analysis of peritoneal fluid, Brokelman et al also showed the presence of uPA, concluding that there is no place for a further hypothesis of inhibition of intraperitoneal fibrinolysis during peritonitis [18].…”

Section: Discussionsupporting

confidence: 85%

“…A reduced peritoneal fibrinolytic capacity after surgery is pointed out by many authors. Many of them regard it as the main cause of postoperative adhesions [11,12,13]. It is confirmed by other studies which have shown that peritoneal fibrinolytic activity could be depressed not only by surgery but also by inflammatory process of the peritoneum [14].…”

Section: Introductionmentioning

confidence: 73%

See 1 more Smart Citation

Urokinase of plasminogen activator (uPA) in peritoneal fluid in patients with peritonitis

Czeszak¹,

Moskwa-Ziętek²,

Ziętek

2019

Pomeranian Journal of Life Sciences

View full text Add to dashboard Cite

Introduction: There is a perturbation of the natural intra-peritoneal environment in peritonitis. The significant issue for treatment outcomes of peritonitis is connected with intra-peritoneal fibrinolysis.The aim of the study was to determine the concentration of urokinase plasminogen activator (uPA) in peritoneal fluid in patients operated for peritonitis.Materials and methods: The study group consisted of 65 patients (28 women and 37 men) at a mean age 45 ±18 years diagnosed with peritonitis. The causes of peritoneal inflammation were acute appendicitis, acute cholecystitis, acute pancreatitis and obstruction of the gastrointestinal tract. The exclusion criterion for the study was cancer, any thrombolytic or antithrombotic therapy. The peritoneal fluid obtained during the surgical procedure was collected for study, in which the concentration of uPA was determined.Results: In the peritoneal fluid of operated patients, uPA was found. The concentration was significantly higher than that determined in their blood plasma (p < 0.0001). Conclusions: The presence of uPA in peritoneal fluid, the concentration of which was significantly higher than in the blood plasma, indicates that during peritonitis there are some conditions for the activation of intra-peritoneal fibrinolysis. However, further investigations are required, including other components of the fibrinolysis cascade.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 73%

Urokinase of plasminogen activator (uPA) in peritoneal fluid in patients with peritonitis

Czeszak¹,

Moskwa-Ziętek²,

Ziętek

2019

Pomeranian Journal of Life Sciences

View full text Add to dashboard Cite

show abstract

“…Tarhan et al have recently decribed the fibrinolytic changes in peritoneal fluid after a cholecystecomy and observed similarities in conventional and laparoscopic cholecystectomies with regard to tPA activity and PAI-1 levels. 17 The timing of the biopsies is an issue that should be addressed. In the present study, we chose to take biopsies at specific moments during the operation.…”

Section: Discussionmentioning

confidence: 99%

The Peritoneal Fibrinolytic Response to Conventional and Laparoscopic Colonic Surgery

Brokelman

Holmdahl

Falk

et al. 2009

Journal of Laparoendoscopic & Advanced Surgical Techniques

View full text Add to dashboard Cite

show abstract

“…Tarhan et al [70] studied peritoneal fluid after both open and laparoscopic cholecystectomy. They found higher tPA levels after the open procedure, possibly in relation to more intense tissue handling.…”

Section: Methodsmentioning

confidence: 99%

Peritoneal changes due to laparoscopic surgery

et al. 2010

View full text Add to dashboard Cite

BackgroundLaparoscopic surgery has been incorporated into common surgical practice. The peritoneum is an organ with various biologic functions that may be affected in different ways by laparoscopic and open techniques. Clinically, these alterations may be important in issues such as peritoneal metastasis and adhesion formation.MethodsA literature search using the Pubmed and Cochrane databases identified articles focusing on the key issues of laparoscopy, peritoneum, inflammation, morphology, immunology, and fibrinolysis.ResultsLaparoscopic surgery induces alterations in the peritoneal integrity and causes local acidosis, probably due to peritoneal hypoxia. The local immune system and inflammation are modulated by a pneumoperitoneum. Additionally, the peritoneal plasmin system is inhibited, leading to peritoneal hypofibrinolysis.ConclusionSimilar to open surgery, laparoscopic surgery affects both the integrity and biology of the peritoneum. These observations may have implications for various clinical conditions.

show abstract

Fibrinolytic responses of human peritoneal fluid in laparoscopic cholecystectomy: a prospective clinical study

Cited by 8 publications

References 35 publications

Urokinase of plasminogen activator (uPA) in peritoneal fluid in patients with peritonitis

Urokinase of plasminogen activator (uPA) in peritoneal fluid in patients with peritonitis

The Peritoneal Fibrinolytic Response to Conventional and Laparoscopic Colonic Surgery

Peritoneal changes due to laparoscopic surgery

Contact Info

Product

Resources

About