Fibrinolytic response to venous occlusion in healthy subjects: Relationship to age, gender, body weight, blood lipids and insulin

Stegnar, Mojca; Pentek, M.

doi:10.1016/0049-3848(93)90005-9

Cited by 48 publications

(26 citation statements)

References 23 publications

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“…In healthy male volunteers, euglobulin lysis time is prolonged apparently reflecting increased PAI-1 implicating impaired fibrinolysis as a function of advanced age (Gleerup and Winther, 1995). Analogous results as a function of age have been obtained in studies of the physiologic response to venous occlusion (Stegnar and Pentek, 1993).…”

Section: Discussionmentioning

confidence: 84%

Increased plasminogen activator inhibitor type-1 (PAI-1) in the heart as a function of age

et al. 2006

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Section: Discussionmentioning

confidence: 84%

Increased plasminogen activator inhibitor type-1 (PAI-1) in the heart as a function of age

et al. 2006

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“…On the contrary, contradictory data were published for factor VII (123,126,130,131), antithrombin III (127,132,133), and protein C (127,132,134). Finally, minor differences were reported for tissue plasminogen activator (tPA) antigen (135)(136)(137)(138) and PA inhibitor (PAI) levels (136,137), whereas fibrinolytic activity (126,135), plasminogen (134), and tPA activity (138) were not significantly different between the two sexes. If differences in hemostatic systems between women and men play a significant role in the different incidence of vascular disease, it remains to be definitively elucidated.…”

Section: Sex-related Differences In Hemostatic Factorsmentioning

confidence: 82%

State-of-the-Art Review : Sex and Cardiovascular Risk Factors

Prisco

Caciolli

Pace

et al. 1996

Clin Appl Thromb Hemost

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It is well known that the incidence of coronary heart disease (CHD) is lower in women than in men, especially in those younger than 50 years of age (1). During the past 20 years, there has been a significant reduction of CHD in western countries attributable not only to improved therapies but also to primary prevention (2).Even if many risk factors for CHD are common in men and women, the impact of each risk factor on the incidence and manifestation of disease may be different. Although many studies have considered the effect of different factors in men, only a limited number of studies contain a significant percentage of women and, finally, very few studies examine separately data from men and from women. This lack of information derives from the less frequent participation of women in research studies. This difference is due in part to the exclusion of women of child-bearing age and in part to the exclusion of elderly women because of their frequent coexisting illnesses (3).We review data in the literature related to the different impact of the risk factors for coronary and other vascular diseases in women in comparison with men. In some cases, we also consider data (when available) concerning the effect of risk-factor modifications.It is now clear that cigarette smoking is associated with CHD in women as in men (4,5). As a consequence of arousing public interest in the risk of smoking, the prevalence of smokers has declined markedly in western countries in the past 20 years, but the decline has been less pronounced in women than in men (6-8) and, in particular, adolescent smokers are more frequently girls (9). In women younger than 65 years of age, the proportion of deaths from CHD directly attributable to smoking has actually increased in the United States from 26% in 1965 to 41% in 1985 (10). The Nurses' Health Study has documented a relative risk of fatal CHD of 5.4 for smokers of --25 cigarettes per day as compared with women who had never smoked (11). Similar data were available for nonfatal myocardial infarction, with a relative risk of 5.8. The association of smoking habit with angina pectoris was weaker, with a relative risk of two to three times in women smoking > 15 cigarettes per day (11). However, even the lightest smokers (1-4 cigarettes per day) had a significantly increased risk of CHD (relative risk 2.4; 11). The risk of CHD tended to be somewhat higher among older women and among women with a parental history of CHD (11).In ex-smokers, a decline in the risk to a level approximating that of women who had never smoked occurred within 3 or 4 years after the cessation of smoking, and it was independent of the amount smoked, the duration of smoking, or the presence of other predisposing factors for myocardial infarction (12,13). Hermanson et al. (14) studied the effects of cessation of smoking in patients with CHD from the CASS Study and found in women, as in men who continued smoking, a higher mortality and a higher risk of myocardial infarction (cumulative relative risk of 1.5) as compared with t...

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“…35 A positive correlation between increased concentration and/or activity and increasing age has been described for fibrinogen, 19 VWF, 16 tPA, 16,34,35 PAI-1, 36,37 and D-dimer. 34 For thrombin-antithrombin complex, a negative correlation was reported. 34…”

Section: Gender and Agementioning

confidence: 87%

“…29 Plasma PAI-1 activity is the main determinant of whole blood fibrinolytic activity in females, whereas tPA and PAI-1 activities equally contribute in males. 33 The association of the tPA activity with gender and age was confirmed by Stegnar, 34 although the correlation was not confirmed in a more recent paper from the same group. 35 A positive correlation between increased concentration and/or activity and increasing age has been described for fibrinogen, 19 VWF, 16 tPA, 16,34,35 PAI-1, 36,37 and D-dimer.…”

Section: Gender and Agementioning

confidence: 95%

“…33 The association of the tPA activity with gender and age was confirmed by Stegnar, 34 although the correlation was not confirmed in a more recent paper from the same group. 35 A positive correlation between increased concentration and/or activity and increasing age has been described for fibrinogen, 19 VWF, 16 tPA, 16,34,35 PAI-1, 36,37 and D-dimer. 34 For thrombin-antithrombin complex, a negative correlation was reported.…”

Section: Gender and Agementioning

confidence: 95%

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Biological Variation in Tests of Hemostasis

Banfi

Fabbro

2008

Semin Thromb Hemost

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The two components of biological variability are interindividual variability, which is the variability due to the heterogeneity of physiologic influences among subjects, and intraindividual variability, which is due to the variability in the same individual over time. Analysis of biological variation is crucial for estimating the critical difference, which corresponds with a threshold suggestive of a statistically significant difference between two consecutive results of a laboratory parameter in the same subject and is therefore unlikely attributable to casual (random) oscillation of values. Studies on biological variation of tests of hemostasis are outdated, and the published results should be confirmed by using modern, fully automated methods. Biological variation for coagulation screening tests (prothrombin time and activated partial thromboplastin time) is low and comparable with the values registered for hematologic parameters. However, the index of individuality (ratio between intraindividual and interindividual variability) suggests that the usual preoperative screening for coagulation disorders is influenced by the between-subjects variability. Thrombin time is very constant within and between subjects. Proteins such as fibrinogen, clotting factors, and antithrombin show a low biological variability. In contrast, fibrinolytic parameters, such as plasminogen activator inhibitor 1 and fibrinopeptide A, show very high variability, and their interpretation in the clinical setting must take this into consideration.

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Fibrinolytic response to venous occlusion in healthy subjects: Relationship to age, gender, body weight, blood lipids and insulin

Cited by 48 publications

References 23 publications

Increased plasminogen activator inhibitor type-1 (PAI-1) in the heart as a function of age

Increased plasminogen activator inhibitor type-1 (PAI-1) in the heart as a function of age

State-of-the-Art Review : Sex and Cardiovascular Risk Factors

Biological Variation in Tests of Hemostasis

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