Fibrinogen levels correlate with stage of disease in patients with oesophageal cancer

Webb, John G.; O'Hanlon, D.M.; Hayes, Nick; Shaw, Ian; Griffin, S. M.

doi:10.1002/bjs.1800840212

Cited by 20 publications

(12 citation statements)

References 13 publications

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“…Fibrinogen is primarily produced in the liver and is converted by the proteolytic action of thrombin. The elevated plasma fibrinogen levels reflect the status of tumor cell-host interactions, and the cellular interactions may be serving as an important contributing factor in cancer development including cell migration, promotion, and inflammatory mediators 47, 48. Secondly, Evaluated CRP and fibrinogen are indicators of tumor-associated inflammatory response, which is companied by up-regulation of cytokines and inflammatory mediators, inhibition of apoptosis, induction of angiogenesis, stimulation of DNA damage and immunosuppression and remodelling of the extracellular matrix, hence promoting tumor growth and metastasis 6, 7.…”

Section: Discussionmentioning

confidence: 99%

A Nomogram based on Inflammatory Factors C-Reactive Protein and Fibrinogen to Predict the Prognostic Value in Patients with Resected Non-Small Cell Lung Cancer

et al. 2017

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Purpose: This study aimed to develop an effective nomogram for predicting survival in surgically treated non-small cell lung cancer patients.Methods: We retrospectively evaluated 856 NSCLC in this study. Cox regression analyses were performed to identify significant prognostic factors for developing a nomogram to predict overall survival (OS). The discriminative ability was assessed with the concordance index (C-index).Results: On multivariate analysis of the 856 cohort, independent factors for survival were CRP, fibrinogen, tumor status, nodal status, distant metastasis and clinical stage, which were entered into the nomogram. The C-index of the established nomogram 0.720 (95% CI: 0.671-0.769) was higher than that of the seventh edition TNM staging system 0.689 (95% CI: 0.668-0.709) for predicting OS (P < 0.05). Compared with patients with low CRP levels (< 8.6 g/L) and low fibrinogen levels (< 3.7 g/L), patients with high CRP and fibrinogen levels had shorter OS. Subgroup analyses revealed that the nomogram was a favorable prognostic parameter in stage I-IV NSCLC (P < 0.05).Conclusion: A nomogram integrating CRP and fibrinogen, which could be convenient and feasible to obtain from the serum preoperatively, may assist in risk stratification for individual patient with resected NSCLC.

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Section: Discussionmentioning

confidence: 99%

A Nomogram based on Inflammatory Factors C-Reactive Protein and Fibrinogen to Predict the Prognostic Value in Patients with Resected Non-Small Cell Lung Cancer

et al. 2017

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“…There is increasing evidence that raised levels of systemic inflammatory markers are associated with poorer survival in patients with cancer. Peripheral blood‐derived inflammation markers including the neutrophil : lymphocyte ratio (NLR), platelet : lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS) and fibrinogen levels have been proposed as potential markers of prognosis in oesophageal cancer. The majority of these studies, however, focused on squamous cell carcinoma of the oesophagus, and thus it is difficult to draw any valid conclusions for a Western population.…”

Section: Introductionmentioning

confidence: 99%

Systemic inflammatory markers and outcome in patients with locally advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction

Jagadesham

Lagarde

Immanuel

et al. 2017

British Journal of Surgery

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“…(7) In addition to its well-known roles in blood coagulation, recent studies have shown that fibrinogen plays important roles in a variety of processes, which include cell-to-cell interactions, inflammation, and cancer progression. (7-9) Elevated fibrinogen can enhance augment lymphatic and hematogeneous metastasis of advanced gastric cancer, which is major determinant of the prognosis in T2 gastric cancer. (10) In a previous study, we found that pre-operative plasma fibrinogen level is a useful marker of extent of tumor progression in gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Plasma Fibrinogen Level Is a Useful Predictor of Adjacent Organ Involvement in Patients with Advanced Gastric Cancer

Lee

Ryu

et al. 2012

J Gastric Cancer

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Purpose The aim of the present study was to assess the association between the pre-operative plasma fibrinogen level and the adjacent organ involvement in advanced gastric cancer. Materials and Methods A total of 923 pre-operative plasma samples were obtained from 923 patients diagnosed clinically as having advanced gastric cancer, and fibrinogen levels were measured by immunoassay. Associations between fibrinogen levels and clinicopathologic findings (depth of tumor, adjacent organ involvement, and lymph node metastasis), along with survival were examined by univariate and multivariate analyses. Results Tumor size, tumor depth, and the presence of lymph node metastasis were found to be positively correlated with the preoperative plasma fibrinogen levels (P<0.001). Fifty (5.4%) patients had adjacent organ involvement. Lymphatic invasion (P<0.001), tumor size (P<0.001), clinical T (depth of invasion) stage (P<0.001), and clinical nodal stage (P=0.018) were found to be associated with adjacent organ involvement. Univariate and multivariate regression analyses showed that a preoperatively elevated plasma fibrinogen level was associated with adjacent organ involvement (P<0.001, 0.028), and Kaplan-Meier analysis showed that it was associated with poorer survival (P<0.001). Conclusions Plasma fibrinogen was found to be a clinically useful marker of adjacent organ involvement and overall survival. When a high fibrinogen level is encountered, preoperatively, adjacent organ involvement should be suspected in clinically advanced gastric cancer.

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Fibrinogen levels correlate with stage of disease in patients with oesophageal cancer

Abstract: This study demonstrates a stage-dependent phenomenon of hyperfibrinogenaemia in association with oesophageal carcinoma.

Cited by 20 publications

References 13 publications

A Nomogram based on Inflammatory Factors C-Reactive Protein and Fibrinogen to Predict the Prognostic Value in Patients with Resected Non-Small Cell Lung Cancer

A Nomogram based on Inflammatory Factors C-Reactive Protein and Fibrinogen to Predict the Prognostic Value in Patients with Resected Non-Small Cell Lung Cancer

Systemic inflammatory markers and outcome in patients with locally advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction

Preoperative Plasma Fibrinogen Level Is a Useful Predictor of Adjacent Organ Involvement in Patients with Advanced Gastric Cancer

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