Fibrin Directs Early Retinal Damage After Experimental Subretinal Hemorrhage

Acute Exudative Maculopathy and Bacillary Layer Detachment in Patients With Central Serous Chorioretinopathy After Photodynamic Therapy

“…It has been postulated that fibrin interdigitation between photoreceptor outer segments may promote their adherence to the RPE microvilli, resulting in BALAD. This mechanism has been reported in experimental subretinal hemorrhages 23 and in hemorrhagic BALAD. 24 Because PAEM is not a well-known complication and there is a lack of large series, management of Fig.…”

Acute Exudative Maculopathy and Bacillary Layer Detachment in Patients With Central Serous Chorioretinopathy After Photodynamic Therapy

“…It has been postulated that fibrin interdigitation between photoreceptor outer segments may promote their adherence to the RPE microvilli, resulting in BALAD. This mechanism has been reported in experimental subretinal hemorrhages 23 and in hemorrhagic BALAD. 24 Because PAEM is not a well-known complication and there is a lack of large series, management of Fig.…”

Long-Term Visual Outcome and Its Predictive Factors Following Treatment of Acute Submacular Hemorrhage with Intravitreous Injection of Tissue Plasminogen Factor and Gas

“…These findings may be explained by outer retinal degeneration such as photoreceptor shearing due to clot retraction, which occurred within 3 to 7 days in the rabbit retina 17 and within 7 to 14 days in the cat retina. 7,18 Despite similar postoperative and final visual acuity improvement, in the study of Hattenbach et al (the mean of follow-up was 4-7 months) and Hassan et al (the mean of follow-up was 10.5 months), the percentage of complete blood displacement was higher than in our study. 11,13,14 However, Hattenbach et al 13 evaluated treatment of small submacular hemorrhage in 25 patients, and Hassan et al 11 also investigated management of small submacular hemorrhage with size £ 4 disc areas (except 2 patients) in 15 patients.…”

RWC Update: Fibrin Glue-Assisted Hemostasis for Persistent Intraoperative Optic Nerve Bleeding; Managing Submacular Hemorrhage; Valsalva Retinopathy Drained with YAG Laser; The EmPuzzled Eye

“…I agree with Dr. Zacharias that SMH may cause retinal damage through a number of mechanisms if management is delayed by more than 14 days 3,4. This underscores the importance of early management.…”

Acute Exudative Maculopathy and Bacillary Layer Detachment in Patients With Central Serous Chorioretinopathy After Photodynamic Therapy

“…It has been postulated that fibrin interdigitation between photoreceptor outer segments may promote their adherence to the RPE microvilli, resulting in BALAD. This mechanism has been reported in experimental subretinal hemorrhages 23 and in hemorrhagic BALAD. 24 Because PAEM is not a well-known complication and there is a lack of large series, management of Fig.…”

Long-Term Visual Outcome and Its Predictive Factors Following Treatment of Acute Submacular Hemorrhage with Intravitreous Injection of Tissue Plasminogen Factor and Gas

“…These findings may be explained by outer retinal degeneration such as photoreceptor shearing due to clot retraction, which occurred within 3 to 7 days in the rabbit retina 17 and within 7 to 14 days in the cat retina. 7,18 Despite similar postoperative and final visual acuity improvement, in the study of Hattenbach et al (the mean of follow-up was 4-7 months) and Hassan et al (the mean of follow-up was 10.5 months), the percentage of complete blood displacement was higher than in our study. 11,13,14 However, Hattenbach et al 13 evaluated treatment of small submacular hemorrhage in 25 patients, and Hassan et al 11 also investigated management of small submacular hemorrhage with size £ 4 disc areas (except 2 patients) in 15 patients.…”

RWC Update: Fibrin Glue-Assisted Hemostasis for Persistent Intraoperative Optic Nerve Bleeding; Managing Submacular Hemorrhage; Valsalva Retinopathy Drained with YAG Laser; The EmPuzzled Eye

“…I agree with Dr. Zacharias that SMH may cause retinal damage through a number of mechanisms if management is delayed by more than 14 days 3,4. This underscores the importance of early management.…”

Acute Exudative Maculopathy and Bacillary Layer Detachment in Patients With Central Serous Chorioretinopathy After Photodynamic Therapy

“…It has been postulated that fibrin interdigitation between photoreceptor outer segments may promote their adherence to the RPE microvilli, resulting in BALAD. This mechanism has been reported in experimental subretinal hemorrhages 23 and in hemorrhagic BALAD. 24 Because PAEM is not a well-known complication and there is a lack of large series, management of Fig.…”

Long-Term Visual Outcome and Its Predictive Factors Following Treatment of Acute Submacular Hemorrhage with Intravitreous Injection of Tissue Plasminogen Factor and Gas

“…These findings may be explained by outer retinal degeneration such as photoreceptor shearing due to clot retraction, which occurred within 3 to 7 days in the rabbit retina 17 and within 7 to 14 days in the cat retina. 7,18 Despite similar postoperative and final visual acuity improvement, in the study of Hattenbach et al (the mean of follow-up was 4-7 months) and Hassan et al (the mean of follow-up was 10.5 months), the percentage of complete blood displacement was higher than in our study. 11,13,14 However, Hattenbach et al 13 evaluated treatment of small submacular hemorrhage in 25 patients, and Hassan et al 11 also investigated management of small submacular hemorrhage with size £ 4 disc areas (except 2 patients) in 15 patients.…”

RWC Update: Fibrin Glue-Assisted Hemostasis for Persistent Intraoperative Optic Nerve Bleeding; Managing Submacular Hemorrhage; Valsalva Retinopathy Drained with YAG Laser; The EmPuzzled Eye

“…I agree with Dr. Zacharias that SMH may cause retinal damage through a number of mechanisms if management is delayed by more than 14 days 3,4. This underscores the importance of early management.…”