Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration

Evaluation of dermal pericapillary fibrin cuffs in venous ulceration using confocal microscopy

“…Fibrin and fibrinogen have a direct down-regulatory effect on procollagen type I synthesis (7). Our results support the therapeutic relevancy of enhancing fibrinolysis in patients with venous disease (9; 10). Conversely, we have shown that keratinocytes attach and spread well in fibrin that is fully cross-linked (11).…”

Venous Leg Ulcer in a Sarcoidosis Patient: A Case Report

“…Falanga et al 6 and Falanga 7 found increased plasma total fibrin-related antigen and D-dimer level in patients with venous disease, reflecting elevated fibrin formation in the body. In addition, it was observed that fibrin cuff encircles the dermal capillary of the venous ulcer lesion on direct immunofluorescence.…”

Venous Leg Ulceration

“…These precapillary cuffs were assumed to act as a physical barrier, which impede the diffusion of oxygen and nutrients, resulting in ischemia, cell death, and ulceration [17][18][19]. In addition, local and systemic fibrinolytic/coagulation abnormalities such as prolonged euglobulin lysis time, elevated plasma fibrinogen levels, increased levels of protein C, fibrin-related antigens, D-dimer, D-monomer, fibrin monomer, and reduction in factor XIII activity may present in patients with venous disease [20][21][22]. However, it is unclear whether these abnormalities are primary or secondary to venous disease.…”