volume 29, issue 1, P63-77 2012
DOI: 10.3233/jad-2012-101575
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Ariadna Mendoza-Naranjo, Erick Contreras-Vallejos, Daniel R. Henriquez, Carola Otth, James R. Bamburg, Ricardo B. Maccioni, Christian Gonzalez-Billault

Abstract: The neuronal cytoskeleton regulates numerous processes that occur in normal homeostasis. Under pathological conditions such as those of Alzheimer's disease (AD), major alterations in cytoskeleton organization have been observed and changes in both microtubules and actin filaments have been reported. Many neurodegenerative consequences of AD are linked to the production and accumulation of amyloid peptides (Aβ) and their oligomers, produced from the internal cleavage of the amyloid-β protein precursor. We previ…

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