Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2016
2016
2017
2017

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 5 publications
(3 citation statements)
references
References 8 publications
(12 reference statements)
0
3
0
Order By: Relevance
“…The exact regulation of this inverse relationship is unknown, but it could be regulated by post-translational methods. Adiponectin is known to antagonize insulin resistance by enhancing hepatic IRS-2 expression [33] , potentially mediated by FGF-21 [34] . Excess adipose tissue is therefore a dynamic organ that can either enhance or heal the effects of oxidative stress in the body [25] .…”
Section: Relationship Between Obesity and Insulin Resistancementioning
confidence: 99%
“…The exact regulation of this inverse relationship is unknown, but it could be regulated by post-translational methods. Adiponectin is known to antagonize insulin resistance by enhancing hepatic IRS-2 expression [33] , potentially mediated by FGF-21 [34] . Excess adipose tissue is therefore a dynamic organ that can either enhance or heal the effects of oxidative stress in the body [25] .…”
Section: Relationship Between Obesity and Insulin Resistancementioning
confidence: 99%
“…This likely explains why FGF21, even at supra-pharmacological doses, is unable to cause hypoglycaemia. In this sense, the protein functions as a 'homeostatic rheostat', fine-tuning the metabolic tone via regulation of insulin levels resulting from adjustments of insulin sensitivity in its target tissues [106]. Additional biochemical pathways by which FGF21 may regulate glycaemia are linked to increased glucose uptake in various types of fat cells [2,12,56], reductions in circulating FFAs and tissue lipotoxicity [98,[107][108][109], regulation of hepatic glucose flux [10,109], lowering of glucagon [2,110,111] and modulation of glucose-sensitive insulin secretion [112][113][114].…”
Section: Fgf21 and Glucose Metabolismmentioning
confidence: 99%
“…Adiponectin is an adipocyte-derived cytokine with a prominent function in improving insulin sensitivity [ 21 , 22 ], via targeting on mitochondrial functions [ 23 , 24 ]. The anti-obesity and insulin-sensitizing actions of adiponectin are mediated by its receptors occurring in two isoforms, adipoR1 and adipoR2 [ 25 ].…”
Section: Introductionmentioning
confidence: 99%