2019
DOI: 10.1016/j.stemcr.2019.04.003
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Abstract: Summary Idiopathic pulmonary fibrosis is a common form of interstitial lung disease resulting in alveolar remodeling and progressive loss of pulmonary function because of chronic alveolar injury and failure to regenerate the respiratory epithelium. Histologically, fibrotic lesions and honeycomb structures expressing atypical proximal airway epithelial markers replace alveolar structures, the latter normally lined by alveolar type 1 (AT1) and AT2 cells. Bronchial epithelial stem cells (BESCs) can giv… Show more

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Cited by 90 publications
(102 citation statements)
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References 57 publications
(82 reference statements)
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“…We found Fgfr2 to be higher in the distal airway club cells compared to proximal airway club cells at 3 and 6 weeks after bleomycin injury ( Figures 6A-C, P). These findings are consistent with our previous report on the role of Fgf10-Fgfr2 signaling in alveolar epithelial regeneration by bronchial epithelial stem cells (Yuan et al, 2019). We found similarly high expression of Fgfr2 in regeneration AT2 cells upon bleomycin injury ( Figures 6D-F, P and S2) and in proximal neo-basal cells but significantly lower expression of Fgfr2 in more distal neo-basal cells ( Figures 6G-I, P), consistent with our previous finding that Fgfr2 is required for the development of neo-basal cells upon bleomycin injury and that increased Fgf10 signaling can drive these cells along the AT2 cell lineage whereas reduced Fgfr2 signaling leads to their differentiation into AT1 cells (Yuan et al, 2019).…”
Section: Dynamic Fgfr1 and Fgfr2 Expression After Naphthalene Or Bleosupporting
confidence: 94%
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“…We found Fgfr2 to be higher in the distal airway club cells compared to proximal airway club cells at 3 and 6 weeks after bleomycin injury ( Figures 6A-C, P). These findings are consistent with our previous report on the role of Fgf10-Fgfr2 signaling in alveolar epithelial regeneration by bronchial epithelial stem cells (Yuan et al, 2019). We found similarly high expression of Fgfr2 in regeneration AT2 cells upon bleomycin injury ( Figures 6D-F, P and S2) and in proximal neo-basal cells but significantly lower expression of Fgfr2 in more distal neo-basal cells ( Figures 6G-I, P), consistent with our previous finding that Fgfr2 is required for the development of neo-basal cells upon bleomycin injury and that increased Fgf10 signaling can drive these cells along the AT2 cell lineage whereas reduced Fgfr2 signaling leads to their differentiation into AT1 cells (Yuan et al, 2019).…”
Section: Dynamic Fgfr1 and Fgfr2 Expression After Naphthalene Or Bleosupporting
confidence: 94%
“…During postnatal lung development, we found strong Fgfr2 expression in AT2 cells and strong Fgfr1 signaling in adjacent mesenchymal alveolar niche cells or lipofibroblasts ( Figures 4A-D, U-Y). Interestingly, Fgfr2 expression was still present in AT1 cells but at lower level than in AT2 cells (Figures 4E-H, Y), which is consistent with an important role for Fgfr2 signaling in AT2 stem cell maintenance (Yuan et al, 2019). We further found Fgfr2 expression in club cells ( Figures 4M-P…”
Section: Fgfr1 and Fgfr2 Expression During Postnatal Lung Developmentsupporting
confidence: 81%
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“…Still, we observed significantly higher expression of markers of all lung cell lineages, suggesting that FGF10 promoted organoid differentiation to both airway and distal lung epithelium. This is consistent with the reported role of FGF10 in regulation of lung progenitor differentiation based on the developmental context (Volckaert et al, 2013) as well as during homeostasis and in regeneration (Volckaert et al, 2017; Yuan et al, 2019).…”
Section: Discussionsupporting
confidence: 92%