Fgf signalling controls the dorsoventral patterning of the zebrafish embryo

Fürthauer, Maximilian; Celst, Jeanne Van; Thisse, Christine; Thisse, Bernard

doi:10.1242/dev.01156

Cited by 241 publications

(301 citation statements)

References 50 publications

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“…To further investigate the regulation of mdkb by FGF signaling, we injected 30 pg of medaka fgf8 mRNA into early zebrafish embryos. The injected embryos showed characteristic developmental defects, including the loss of ventral and posterior structures, similar to what has been described for ectopic expression of zebrafish fgf8 (Furthauer et al, 1997). In fgf8-injected embryos, expression of mdkb was not restricted to the dorsal side at 90% epiboly, but was instead expanded into ventral domains in 95% of injected embryos (n ϭ 20; Fig.…”

Section: Regulation Of Mdkb Expression During Neural Crest Inductionsupporting

confidence: 73%

Midkine‐b regulates cell specification at the neural plate border in zebrafish

Liedtke

Winkler

2007

Developmental Dynamics

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Section: Regulation Of Mdkb Expression During Neural Crest Inductionsupporting

confidence: 73%

Midkine‐b regulates cell specification at the neural plate border in zebrafish

Liedtke

Winkler

2007

Developmental Dynamics

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“…EF1␣ and ODC were used as loading controls. more dorsal cell fate in the embryo because a reduction in FGF8 enhances the ventralization seen in chordino mutants (Furthauer et al, 2004); furthermore, FGF signaling is necessary for proper establishment of dorsal mesoderm in the fish, since ␤-catenin-mediated induction of both gsc and chordin is absent when FGF signaling is inhibited (Maegawa et al, 2006). In Xenopus, however, FGF overexpression does not induce axial, organizer gene expression though it does expand early non-axial mesodermal domains and posteriorize the embryo (Isaacs et al, 1994;Pownall et al, , 2003Christen and Slack, 1997;Lombardo et al, 1998;Fletcher et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

The role of FGF signaling in the establishment and maintenance of mesodermal gene expression in Xenopus

Fletcher

Harland

2008

Developmental Dynamics

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FGF signaling is important for the formation of mesoderm in vertebrates, and when it is perturbed in Xenopus, most trunk and tail mesoderm fails to form. Here we have further dissected the activities of FGF in patterning the embryo by addressing its inductive and maintenance roles. We show that FGF signaling is necessary for the establishment of xbra expression in addition to its well-characterized role in maintaining xbra expression. The role of FGF signaling in organizer formation is not clear in Xenopus. We find that FGF signaling is essential for the initial specification of paraxial mesoderm but not for activation of several pan-mesodermal and most organizer genes; however, early FGF signaling is necessary for the maintenance of organizer gene expression into the neurula stage. Inhibition of FGF signaling prevents VegT activation of specific mesodermal transcripts. These findings illuminate how FGF signaling contributes to the establishment of distinct types of mesoderm.

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“…3 G, I, and J). FGF signaling can dorsalize zebrafish embryos (31). Because Ier2 and Fibp1 are induced by FGF and may participate in FGF signal transduction we tested for effects of the MOs on dorsal/ventral axis specification.…”

Section: B D E-l)mentioning

confidence: 99%

FGF-dependent left–right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1

Hong

Dawid

2009

Proc. Natl. Acad. Sci. U.S.A.

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Establishment of left-right asymmetry in vertebrates requires nodal, Wnt-PCP and FGF signaling and involves ciliogenesis in a laterality organ. Effector genes through which FGF signaling affects laterality have not been described. We isolated the zebrafish ier2 and fibp1 genes as FGF target genes and show that their protein products interact. Knock down of these factors interferes with establishment of organ laterality and causes defective cilia formation in Kupffer's Vesicle, the zebrafish laterality organ. Cilia are also lost after suppression of FGF8, but can be rescued by injection of ier2 and fibp1 mRNA. We conclude that Ier2 and Fibp1 mediate FGF signaling in ciliogenesis in Kupffer's Vesicle and in the establishment of laterality in the zebrafish embryo.ciliogenesis ͉ Kupffer's vesicle ͉ laterality

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Fgf signalling controls the dorsoventral patterning of the zebrafish embryo

Cited by 241 publications

References 50 publications

Midkine‐b regulates cell specification at the neural plate border in zebrafish

Midkine‐b regulates cell specification at the neural plate border in zebrafish

The role of FGF signaling in the establishment and maintenance of mesodermal gene expression in Xenopus

FGF-dependent left–right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1

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