Infectious Disease Clinics of North America volume 21, issue 4, P1213-1220 2007 DOI: 10.1016/j.idc.2007.08.007 View full text
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Charles S. Bryan, Divya Ahuja

Abstract: Empiric therapy has little or no role to play in cases of classic fever of unknown origin with three important exceptions: cases that meet criteria for culture-negative endocarditis; cases in which findings or the clinical setting suggests cryptic disseminated tuberculosis (or, occasionally, other granulomatous infections); and cases in which temporal arteritis with vision loss is suspected. Several studies indicate that patients with prolonged, undiagnosed fever of unknown origin generally have a favorable pr…

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