Fetal Tracheal Ligation And Lung Development

Development of Salt and Water Transport across Airway and Alveolar Epithelia

“…127,128 Similar findings had earlier been reported for congenital obstructions of the trachea in human fetuses. 127,128 Similar findings had earlier been reported for congenital obstructions of the trachea in human fetuses.…”

Distensibility of the Fetal Lung with Fluid in Sheep

“…Distention of the lung after ligation of the fetal trachea has been found in rabbits [5,14], and in sheep [3]. The rate of lung fluid formation which we observed in near term sheep fetuses (0.013-0.055 ml/kg/min) compares with rates of 0.014-0.13 ml/kg/min observed in fetal lambs by others [9,18].…”

Formation of Liquid in the Lungs of the Foetal Lamb

“…Josr and Policard [8] showed by ligating the trachea of fetal rabbits that the lungs became abnormally distended after a few days. Towers [9] and Carmel, F riedman and A dams [10] reached the same conclusion from similar experiments. The formation of lung liquid in situ was also supported by the finding of Adams, Moss and Fagan [30] that electrolyte concentrations in the lung liquid of lambs differed from those in plasma or amniotic fluid.…”