Fetal tissue engineering: Diaphragmatic replacement

Fauza, Dario O.; Marler, Jennifer J.; Koka, Rahul; Forse, R. Armour; Mayer, John E.; Vacanti, Joseph P.

doi:10.1053/jpsu.2001.20034

Cited by 99 publications

(62 citation statements)

References 17 publications

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“…Tal como indica Fauza et al, dichas matrices acelulares son insuficientes por si solas, para la reparación de la pared abdominal (34), por lo que se hace necesario disponer de células (autólo-gas, alogénicas o xenogénicas), que se cultiven sobre ellas junto con distintas moléculas bioactivas que estimulen su desarrollo (5).…”

Section: Terapias Basadas En Técnicas De Ingeniería Tisu-larunclassified

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2015

Actual. Med.

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Section: Terapias Basadas En Técnicas De Ingeniería Tisu-larunclassified

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2015

Actual. Med.

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“…Using our index condition as an example, diaphragmatic reconstruction might be undertaken using a collagen matrix, seeded with native fibrous or muscular cells. Fauza et al (2001) already suggested this 10 years ago, hoping this would create a more functional substitute than the inert synthetic grafts currently in use (Kunisaki et al, 2006). These strategies may also be used to create a matrix for stimulating fetal membrane healing (Ochsenbein-Köble et al, 2007;Mallik et al, 2007).…”

Section: The Futurementioning

confidence: 99%

The making of fetal surgery

et al. 2010

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Fetal diagnosis prompts the question for fetal therapy in highly selected cases. Some conditions are suitable for in utero surgical intervention. This paper reviews historically important steps in the development of fetal surgery. The first invasive fetal intervention in 1963 was an intra-uterine blood transfusion. It took another 20 years to understand the pathophysiology of other candidate fetal conditions and to develop safe anaesthetic and surgical techniques before the team at the University of California at San Francisco performed its first urinary diversion through hysterotomy. This procedure would be abandoned as renal and pulmonary function could be just as effectively salvaged by ultrasound-guided insertion of a bladder shunt. Fetoscopy is another method for direct access to the feto-placental unit. It was historically used for fetal visualisation to guide biopsies or for vascular access but was also abandoned following the introduction of high-resolution ultrasound. Miniaturisation revived fetoscopy in the 1990s, since when it has been successfully used to operate on the placenta and umbilical cord. Today, it is also used in fetuses with congenital diaphragmatic hernia (CDH), in whom lung growth is triggered by percutaneous tracheal occlusion. It can also be used to diagnose and treat urinary obstruction. Many fetal interventions remain investigational but for a number of conditions randomised trials have established the role of in utero surgery, making fetal surgery a clinical reality in a number of fetal therapy programmes. The safety of fetal surgery is such that even non-lethal conditions, such as myelomeningocoele repair, are at this moment considered a potential indication. This, as well as fetal intervention for CDH, is currently being investigated in randomised trials.

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“…Lai et al (2003) had proven that scaffolds covered with cells had better mechanical properties than acellular/non-seeded scaffolds in body wall repair using small intestinal submucosa seeded with cells. Fauza et al (2001) had also reported acellular collagen-based matrix alone may be insufficient scaffold for abdominal wall reconstruction. However, in our study none of the treatment groups, in both types of scaffolds have showed pouching and distension appearance of the abdominal wall, rather various degree of tissue regeneration was noticed, which was evidenced by graft opacity, and overwhelming blood vessels, fatty tissues, fibrous tissue and neo-peritoneum was observed in myoblast seeded groups of both type of scaffolds at 30 days of post-implantation ( Figure 14).…”

Section: Macroscopic Analysismentioning

confidence: 99%

Tissue Engineering for Tissue and Organ Regeneration

Eberli¹

2011

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Fetal tissue engineering: Diaphragmatic replacement

Cited by 99 publications

References 17 publications

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The making of fetal surgery

Tissue Engineering for Tissue and Organ Regeneration

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