Fetal Lung Hypoplasia Associated with Maternal Smoking: A Morphometric Analysis

Mh, Collins; Ac, Moessinger; Kleinerman, Jerome; Bassi, Jorge; Rosso, Pedro; Am, Collins; Ls, James; Wa, Blanc

doi:10.1203/00006450-198519040-00018

Cited by 176 publications

(113 citation statements)

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“…A marked reduction in fetal movements has been reported for at least an hour after the mother has smoked (Thaler et al, 1980). Nicotine may act as a vasoconstrictor, resulting in reduced placental blood flow, reduced supply of nutrients and oxygen to the fetus, and growth retardation and placenta grows and spreads over a wider area (Collins et al, 1985;Üstün and Malatyalıoğlu, 1990). We found that 21.2% of mothers had smoked before pregnancy, and 16.3% of them continued smoking during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Maternal smoking during pregnancy is known to affect fetal growth and the placenta, increasing the risk of giving birth to a small for gestational-age infant (Kramer, 1987;Miller and Jekel, 1989). e potential effects of smoking during pregnancy on lung and airway development may include structual alterations (Collins et al, 1985). A marked reduction in fetal movements has been reported for at least an hour after the mother has smoked (Thaler et al, 1980).…”

Section: Discussionmentioning

confidence: 99%

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The relationship between maternal, placental and newborn parameters

Erbi̇l

Toprak²,

Açıkgöz³

et al. 2015

Mid. Black Sea J of Health Sci.

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Objective: The aim of this study was to investigate the relationship between maternal, placental and newborn parameters. Methods: The study was conducted in the delivery unit, Ordu province, Turkey. The sample consisted of 104 women who had agreed to participate in the research and whose pregnancy had reached 37 weeks or over. Only singleton births were included. The placental and newborn parameters were measured after delivery. Results: We found that the mean placental weight was 563.6±135.65 grs, and the mean of newborn weight was 3358±487.58 grs. The placental weight was significantly positively correlated with infant's birth weight (p=.000), infant's length (p=.024), maternal weight before pregnancy (p=.021), maternal weight on last day of pregnancy (p=.002) and maternal Body Mass Index (BMI) (p=.015) The placental weight of smoker during pregnancy was 628.82±107.40 grams; placental weight of non-smoker during pregnancy was 550.91±137.44 grams, and the difference was statistically significant (p=.007).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The relationship between maternal, placental and newborn parameters

Erbi̇l

Toprak²,

Açıkgöz³

et al. 2015

Mid. Black Sea J of Health Sci.

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show abstract

“…In particular, maternal smoking has been independently associated with an increased risk for the development of asthma, diminished lower airway function, and the development of wheezing in infants, which can persist into the first few years of life (5,10). The underlying mechanisms by which these associations occur are not well understood, but it has been postulated that infants who are exposed to tobacco smoke have smaller airways that may predispose to airway obstruction (3). Since environmental tobacco smoke has already been established as a risk factor for abnormal fetal events such as stillbirth, premature birth, and low birth weight, it has been speculated that alterations in lung development in utero explain these changes seen in the lung (29).…”

mentioning

confidence: 99%

Nicotine alters lung branching morphogenesis through the α₇ nicotinic acetylcholine receptor

Wongtrakool

Roser‐Page²,

Rivera³

et al. 2007

American Journal of Physiology-Lung Cellular and Molecular Phys

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There is abundant epidemiological data linking prenatal environmental tobacco smoke with childhood asthma and wheezing, but the underlying molecular and physiological mechanisms that occur in utero to explain this link remain unelucidated. Several studies suggest that nicotine, which traverses the placenta, is a causative agent. Therefore, we studied the effects of nicotine on lung branching morphogenesis using embryonic murine lung explants. We found that the expression of α7 nicotinic acetylcholine receptors, which mediate many of the biological effects of nicotine, is highest in pseudoglandular stage lungs compared with lungs at later stages. We then studied the effects of nicotine in the explant model and found that nicotine stimulated lung branching in a dose-dependent fashion. α-Bungarotoxin, an antagonist of α7 nicotinic acetylcholine receptors, blocked the stimulatory effect of nicotine, whereas GTS-21, a specific agonist, stimulated branching, thereby mimicking the effects of nicotine. Explants deficient in α7 nicotinic acetylcholine receptors did not respond to nicotine. Nicotine also stimulated the growth of the explant. Altogether, these studies suggest that nicotine stimulates lung branching morphogenesis through α7 nicotinic acetylcholine receptors and may contribute to dysanaptic lung growth, which in turn may predispose the host to airway disease in the postnatal period.

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“…The potentially mutagenic effects of tobacco smoke may impair normal cellular division and differentiation in the respiratory tree, leading to reduced lung function and increased bronchial hyperresponsiveness (Collins et al, 1985;Young et al, 1991;Cook et al, 1998). Animal studies demonstrate histological changes, including hyperplasia of bronchial muscles and prematurity of lung tissues in the fetal lung secondary to the effects of in utero exposure to tobacco smoke (Neslon et al, 1999).…”

Section: ) Indoor Airmentioning

confidence: 99%

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

Liu

Xia

Guo

et al. 2012

J Expo Sci Environ Epidemiol

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The urinary metabolites of phthalates are well-accepted exposure biomarkers for adults and children older than 6 years but are not commonly used for infants owing to non-convenient sampling. In the light of this situation, a novel sampling method based on monitoring the urine expressed from the gel diaper was developed. The urine was expressed from the gel absorbent after mixing the absorbent with CaCl2 and then collected by a laboratory-made device; the urinary phthalate metabolites were extracted and cleaned using a solid-phase extraction (SPE) column and analyzed with high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry / mass spectrometry. To evaluate the method's feasibility, the following factors were investigated: the proportion of CaCl2 to gel absorbent, the urination volume variation and the target compounds' deposition bias in the diaper, the matrix blank of the different diaper brands, the storage stabilities and the recoveries of creatinine and phthalate metabolites in the expressed urine. Mono-methyl phthalate, mono-ethyl phthalate, mono-butyl phthalate, mono-benzyl phthalate, mono-2-ethylhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate were involved. 70-80% of the urine can be expressed from the diaper, and the expressed spiking recoveries and the limit of detection of mono-phthalates ranged from 88.5-115% and 0.21-0.50 ng/ml. The method was applied to measure phthalate metabolites in 65 gel diaper samples from 15 infants, and the pilot data suggests the infants are commonly exposed to phthalates. In summary, the method for monitoring of infant exposure to phthalates is sound and validated, and the potential health effects from the vulnerable infants' exposure to phthalates should be concerned.39th Scientific Research Foundation for the Returned Overseas Chinese Scholars (SRF for ROCS); Hundred Talent Program of Chinese Academy of Sciences (CAS); CAS/SAFEA International Partnership Program for Creative Research Teams [KZCX2-YW-T08

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Fetal Lung Hypoplasia Associated with Maternal Smoking: A Morphometric Analysis

Cited by 176 publications

References 0 publications

The relationship between maternal, placental and newborn parameters

The relationship between maternal, placental and newborn parameters

Nicotine alters lung branching morphogenesis through the α₇ nicotinic acetylcholine receptor

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

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Fetal Lung Hypoplasia Associated with Maternal Smoking: A Morphometric Analysis

Cited by 176 publications

References 0 publications

The relationship between maternal, placental and newborn parameters

The relationship between maternal, placental and newborn parameters

Nicotine alters lung branching morphogenesis through the α7 nicotinic acetylcholine receptor

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

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About

Nicotine alters lung branching morphogenesis through the α₇ nicotinic acetylcholine receptor