Fetal gender, serum human chorionic gonadotropin, and testosterone in women with preeclampsia

Ibrahim, Zakia M.; Kishk, Eman Ahmed; Elzamlout, Mahmoud S; Elshahat, Amal M.; Taha, Omima T.

doi:10.1080/10641955.2020.1765174

Cited by 10 publications

(11 citation statements)

References 13 publications

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“…Some studies have reported that plasma or serum E2 concentrations were down‐regulated, whereas other studies reported that there were no significant changes in preeclamptic compared to normotensive pregnant women during the first and second trimesters 17–19 . The majority of published studies have shown the level of T in PE patients at different gestational weeks was generally high, but some reports indicated that there were no changes in the level of T in PE patients 20–23 . Aromatase (CYP19A) is a rate‐limiting enzyme for estrogen biosynthesis, which converts T into E2 in the placenta.…”

Section: Discussionmentioning

confidence: 99%

“… 17 , 18 , 19 The majority of published studies have shown the level of T in PE patients at different gestational weeks was generally high, but some reports indicated that there were no changes in the level of T in PE patients. 20 , 21 , 22 , 23 Aromatase (CYP19A) is a rate‐limiting enzyme for estrogen biosynthesis, which converts T into E2 in the placenta. It was reported that there was no significant difference in CYP19A1 between the plasma of patients with preeclampsia and that of normal people by GC–MS.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies demonstrated that fetal sex was associated with different patterns of ultrasonic markers of placentation, 34 placental pathology, 35 the risk of perinatal death, 36 and PE. 28 , 37 , 38 Nevertheless, there were also reports that women with early preterm PE (< 34 weeks) had higher odds with a female fetus. 39 It was reported that the levels of T and E2 may be correlated with fetal sex.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19] The majority of published studies have shown the level of T in PE patients at different gestational weeks was generally high, but some reports indicated that there were no changes in the level of T in PE patients. [20][21][22][23] Aromatase (CYP19A) is a rate-limiting enzyme for estrogen biosynthesis, which converts T into E2 in the placenta.…”

Section: Ta B L Ementioning

confidence: 99%

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Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester

Shen

Cao

Yao

et al. 2022

J of Clinical Hypertension

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Preeclampsia (PE) is the most common medical complication during pregnancy and the second leading cause of maternal death worldwide. However, a better predictive model of PE remains to be explored. A total of 15 severe preeclampsia (sPE) and 75 healthy control patients were included in this study. Patient data was obtained from September 2019 to September 2021. Nuchal translucency (NT) and crown-rump length (CRL) of the fetus were acquired by ultrasound. Maternal blood samples were collected at 11 +0 to 13 +6 weeks of gestation. Chemiluminescent immunoassays were used to detect serum testosterone (T) and estradiol (E2) levels. Time-resolved fluorescence analysis was used to examine the levels of serum pregnancy-associated plasma protein A (PAPPA) and β-human chorionic gonadotrophin (β-HCG) protein. The sPE group exhibited increased T levels, and decreased E2 levels and E2/T ratios from 11 to 14 weeks of gestation, compared with the control group. E2 and the E2/T ratio showed positive linear correlation with CRL in pregnant women. Body-mass-index (BMI), T, and E2 were determined to be the main factors that affected the occurrence of sPE at the 12week gestation period time point. The receiver operating characteristic (ROC) curve revealed that the AUC of the E2/T ratio was .717. The imbalanced T and E2 levels in the patients had a specific intrinsic relevance with sPE, which suggests them as novel predictors of the sPE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Ta B L Ementioning

confidence: 99%

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Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester

Shen

Cao

Yao

et al. 2022

J of Clinical Hypertension

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“…Vitamin E together with vitamin C or independently had been found to be protective for preeclampsia [63][64][65]. Paricalcitol is a synthetic analog of vitamin D, calcifediol is a metabolite of vitamin D3 and DL-alpha-tocopherol is a synthetic analog of vitamin E. On the other hand, drostanolone is an anabolic steroid similar to testosterone and this hormone is found to be elevated in preeclampsia [25,[66][67][68][69]. Therefore, these drugs are not good candidates for preeclampsia treatment.…”

Section: Drug Repurposingmentioning

confidence: 99%

A Multi-Objective Approach for Drug Repurposing in Preeclampsia

et al. 2021

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Preeclampsia is a hypertensive disorder that occurs during pregnancy. It is a complex disease with unknown pathogenesis and the leading cause of fetal and maternal mortality during pregnancy. Using all drugs currently under clinical trial for preeclampsia, we extracted all their possible targets from the DrugBank and ChEMBL databases and labeled them as “targets”. The proteins labeled as “off-targets” were extracted in the same way but while taking all antihypertensive drugs which are inhibitors of ACE and/or angiotensin receptor antagonist as query molecules. Classification models were obtained for each of the 55 total proteins (45 targets and 10 off-targets) using the TPOT pipeline optimization tool. The average accuracy of the models in predicting the external dataset for targets and off-targets was 0.830 and 0.850, respectively. The combinations of models maximizing their virtual screening performance were explored by combining the desirability function and genetic algorithms. The virtual screening performance metrics for the best model were: the Boltzmann-Enhanced Discrimination of ROC (BEDROC)α=160.9 = 0.258, the Enrichment Factor (EF)1% = 31.55 and the Area Under the Accumulation Curve (AUAC) = 0.831. The most relevant targets for preeclampsia were: AR, VDR, SLC6A2, NOS3 and CHRM4, while ABCG2, ERBB2, CES1 and REN led to the most relevant off-targets. A virtual screening of the DrugBank database identified estradiol, estriol, vitamins E and D, lynestrenol, mifrepristone, simvastatin, ambroxol, and some antibiotics and antiparasitics as drugs with potential application in the treatment of preeclampsia.

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