Am J Dis Child
 1982
DOI: 10.1001/archpedi.1982.03970410034007
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Fetal Exposure to Maternal Hyperbilirubinemia

Feizal Waffarn1
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Cited by 14 publications

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“…Theoretically, a persistence of very high maternal bilirubin levels might disrupt the normal transplacental flow of fetal bilirubin, leading to intrauterine hyperbilirubinaemia. The actual threshold of maternal bilirubin level and the duration of elevation required to disrupt normal transplacental flow are unknown, and data are limited to case studies with conflicting results [27–30]. This study had a conservative rule whereby a maternal bilirubin level of 10 mg/dL at any time or a level of 7.5 mg/dL persisting for 2 weeks mandated discontinuation of the study drug.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Theoretically, a persistence of very high maternal bilirubin levels might disrupt the normal transplacental flow of fetal bilirubin, leading to intrauterine hyperbilirubinaemia. The actual threshold of maternal bilirubin level and the duration of elevation required to disrupt normal transplacental flow are unknown, and data are limited to case studies with conflicting results [27–30]. This study had a conservative rule whereby a maternal bilirubin level of 10 mg/dL at any time or a level of 7.5 mg/dL persisting for 2 weeks mandated discontinuation of the study drug.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In Gunn rats, maternal hyperbilirubinemia has been reported to decrease pregnancy rates ( 72 ). In humans, maternal hyperbilirubinemia increases preterm birth rates ( 73 ), but the prognosis for the infants is better in late pregnancy ( 74 ).…”
Section: Fetal Bilirubin Metabolismmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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