Fetal cleft lip repair in rabbits: Postnatal facial growth after repair

Intrauterine autogenous foetal bone transplantation for the repair of cleft-like defects in the mid-gestational sheep model

“…According to our study, intrauterine repair of cleft-like defects leads to poor results, similar to those reported by Stelnicki et al (1998a), but in contrast with previous studies on intrauterine cleft surgery (Dodson et al, 1991;Estes et al, 1992;Hedrick et al, 1996;Smith et al, 1997;Oberg et al, 1998Oberg et al, , 1999. Nevertheless, this study demonstrates the feasibility of treatment of the maxillary alveolar defect.…”

“…It was thought that the foetus would benefit from the two most important advantages of mid-gestational intrauterine surgery by such Intrauterine autogenous foetal bone transplantation 203 an intervention: scarless wound healing (Rowlatt, 1979;Longaker et al, 1992a;Mackool et al, 1998) and bone healing without callus formation (Michejda et al, 1981;Longaker et al, 1992b;Goldstein et al, 1994). These factors are very important since scarring is aesthetically unattractive, and leads to diminished maxillary growth in combination with maxillary defects (Bardach et al, 1980;Dodson et al, 1991;Canady et al, 1997). To date no research group has attempted to evaluate a surgical method for treating the alveolar defect in a cleft of lip and alveolus with a oronasal fistula.…”

Intrauterine autogenous foetal bone transplantation for the repair of cleft-like defects in the mid-gestational sheep model

“…According to our study, intrauterine repair of cleft-like defects leads to poor results, similar to those reported by Stelnicki et al (1998a), but in contrast with previous studies on intrauterine cleft surgery (Dodson et al, 1991;Estes et al, 1992;Hedrick et al, 1996;Smith et al, 1997;Oberg et al, 1998Oberg et al, , 1999. Nevertheless, this study demonstrates the feasibility of treatment of the maxillary alveolar defect.…”

“…It was thought that the foetus would benefit from the two most important advantages of mid-gestational intrauterine surgery by such Intrauterine autogenous foetal bone transplantation 203 an intervention: scarless wound healing (Rowlatt, 1979;Longaker et al, 1992a;Mackool et al, 1998) and bone healing without callus formation (Michejda et al, 1981;Longaker et al, 1992b;Goldstein et al, 1994). These factors are very important since scarring is aesthetically unattractive, and leads to diminished maxillary growth in combination with maxillary defects (Bardach et al, 1980;Dodson et al, 1991;Canady et al, 1997). To date no research group has attempted to evaluate a surgical method for treating the alveolar defect in a cleft of lip and alveolus with a oronasal fistula.…”

Treacher Collins syndrome: etiology, pathogenesis and prevention

“…Fetal surgery became technically feasible during the 1980s 38 and intrauterine repair of cleft palate, for example, is possible both in theory and practice. 39,40 However, at present, there is no universal recommendation for the in utero correction of prenatally diagnosed craniofacial anomalies and the decision to pursue fetal surgical intervention carries with it the potential for dual mortality (mother and fetus). Thus, fetal surgery at present remains experimental and controversial.…”

Laser burn wound healing in naso‐labial region of fetal and neonatal mice

“…Many cleft lip repair studies have been done in postnatal rabbits (Bardach et al , 1980), fetal rabbits (Longaker et al , 1990a; Dodson et al , 1991; Stern et al , 1992), and fetal sheep (Stern et al , 1993). These sequential studies also indicated the specificity of lip wound in terms of the difficulty for healing.…”

Intrauterine autogenous foetal bone transplantation for the repair of cleft-like defects in the mid-gestational sheep model

“…According to our study, intrauterine repair of cleft-like defects leads to poor results, similar to those reported by Stelnicki et al (1998a), but in contrast with previous studies on intrauterine cleft surgery (Dodson et al, 1991;Estes et al, 1992;Hedrick et al, 1996;Smith et al, 1997;Oberg et al, 1998Oberg et al, , 1999. Nevertheless, this study demonstrates the feasibility of treatment of the maxillary alveolar defect.…”

“…It was thought that the foetus would benefit from the two most important advantages of mid-gestational intrauterine surgery by such Intrauterine autogenous foetal bone transplantation 203 an intervention: scarless wound healing (Rowlatt, 1979;Longaker et al, 1992a;Mackool et al, 1998) and bone healing without callus formation (Michejda et al, 1981;Longaker et al, 1992b;Goldstein et al, 1994). These factors are very important since scarring is aesthetically unattractive, and leads to diminished maxillary growth in combination with maxillary defects (Bardach et al, 1980;Dodson et al, 1991;Canady et al, 1997). To date no research group has attempted to evaluate a surgical method for treating the alveolar defect in a cleft of lip and alveolus with a oronasal fistula.…”

Treacher Collins syndrome: etiology, pathogenesis and prevention

“…Fetal surgery became technically feasible during the 1980s 38 and intrauterine repair of cleft palate, for example, is possible both in theory and practice. 39,40 However, at present, there is no universal recommendation for the in utero correction of prenatally diagnosed craniofacial anomalies and the decision to pursue fetal surgical intervention carries with it the potential for dual mortality (mother and fetus). Thus, fetal surgery at present remains experimental and controversial.…”

Laser burn wound healing in naso‐labial region of fetal and neonatal mice

“…Many cleft lip repair studies have been done in postnatal rabbits (Bardach et al , 1980), fetal rabbits (Longaker et al , 1990a; Dodson et al , 1991; Stern et al , 1992), and fetal sheep (Stern et al , 1993). These sequential studies also indicated the specificity of lip wound in terms of the difficulty for healing.…”

Intrauterine autogenous foetal bone transplantation for the repair of cleft-like defects in the mid-gestational sheep model

“…According to our study, intrauterine repair of cleft-like defects leads to poor results, similar to those reported by Stelnicki et al (1998a), but in contrast with previous studies on intrauterine cleft surgery (Dodson et al, 1991;Estes et al, 1992;Hedrick et al, 1996;Smith et al, 1997;Oberg et al, 1998Oberg et al, , 1999. Nevertheless, this study demonstrates the feasibility of treatment of the maxillary alveolar defect.…”

“…It was thought that the foetus would benefit from the two most important advantages of mid-gestational intrauterine surgery by such Intrauterine autogenous foetal bone transplantation 203 an intervention: scarless wound healing (Rowlatt, 1979;Longaker et al, 1992a;Mackool et al, 1998) and bone healing without callus formation (Michejda et al, 1981;Longaker et al, 1992b;Goldstein et al, 1994). These factors are very important since scarring is aesthetically unattractive, and leads to diminished maxillary growth in combination with maxillary defects (Bardach et al, 1980;Dodson et al, 1991;Canady et al, 1997). To date no research group has attempted to evaluate a surgical method for treating the alveolar defect in a cleft of lip and alveolus with a oronasal fistula.…”

Treacher Collins syndrome: etiology, pathogenesis and prevention

“…Fetal surgery became technically feasible during the 1980s 38 and intrauterine repair of cleft palate, for example, is possible both in theory and practice. 39,40 However, at present, there is no universal recommendation for the in utero correction of prenatally diagnosed craniofacial anomalies and the decision to pursue fetal surgical intervention carries with it the potential for dual mortality (mother and fetus). Thus, fetal surgery at present remains experimental and controversial.…”

Laser burn wound healing in naso‐labial region of fetal and neonatal mice

“…Many cleft lip repair studies have been done in postnatal rabbits (Bardach et al , 1980), fetal rabbits (Longaker et al , 1990a; Dodson et al , 1991; Stern et al , 1992), and fetal sheep (Stern et al , 1993). These sequential studies also indicated the specificity of lip wound in terms of the difficulty for healing.…”