Fetal Beta2-Microglobulin as a Biomarker of Kidney Disease

Grangé, G.; Leguy, Marie-Clémence; Tsatsaris, Vassilis; Gadrey, Jean

doi:10.1007/978-94-007-7743-9_21-1

Cited by 1 publication

(1 citation statement)

References 72 publications

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“…Up to the 20th week of gestation, fetal urine is isotonic with plasma depicting immaturity of the tubular function. Foetuses with renal damage tend to have hypertonic urine with a higher concentration of proteins as compared to normal fetuses or foetuses with lower urinary tract obstruction [29].…”

Section: Fetal Urine Analysismentioning

confidence: 99%

Hyperechogenic Fetal Kidneys: Uncertain Diagnosis and Unpredictable Future?

Ashutosh

Aneja

Bahl

et al. 2020

Journal of Fetal Medicine

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Glomerulocystic kidney with increased renal echogenicity encompasses a number of renal abnormalities that might have cystic glomeruli and be a sequelae of renal obstruction. Increased echogenicity of the kidneys is a nonspecific finding and a result of varied etiologies. Multiple microscopic cortical and medullary cysts, interstitial fibrosis and mesangial sclerosis are the etiopathogenesis for renal hyperechogenicity even in the absence of macrocysts. The crucial point is poor predictability of antenatal ultrasound to fully define the extent and severity of parenchymal damage and to forecast its outcome at the time of initial diagnosis. The only exception is the most severe forms of cystic dysplasia associated with severe oligohydramnios. Urinary levels of b2-microglobulin may be a valuable marker of fetal renal function. Hyperechogenic fetal kidneys may have varied etiologies and within each etiological group there may have a wide range of outcomes. Challenges lie in counseling after antenatal diagnosis of fetal hyperechogenic kidneys which carry an uncertain course and prognosis.

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Section: Fetal Urine Analysismentioning

confidence: 99%