Fetal and Adult Hemoglobins in Hemolytic Disease of the Newborn

Foetal Haemoglobin in Haemolytic Disease of the Newborn

“…There is a 4 significant correlation between the globin concentration and the Hb-! these respects our results are essent those of Schulman andSmith (1954) Engstrom (1960). However, in con man and Smith's (1954) finding that disease there is an absolute increase tration of Hb-A we are at variance v Engstrom (1960).…”

“…They are, however, important because much of the discussion regarding the interpretation of the changes found in haemolytic disease depends upon * V the conitroversial findings. Briefly it is maintained by Schulman and Smith (1954) that evidence of an increase in concentration of Hb-A indicates a * V V preferential generation of Hb-A in the foetus under V0 * Vstress, while Brody and Engstrom (1960) on their data prefer to revert to the original hypothesis of Jonxis (1948) that there is selective destruction of cells containing Hb-F. In our view the experimental data can be reasonx ably explained without recourse to either preferential x x x x generation of one form of haemoglobin or selective XX x destruction of the other, and the contradictions x xx x can be reconciled by biological variations within x the spectrum of the disease process.…”

Lung injury after asphyxia and hemorrhagic shock in newborn piglets: Analysis of structural and inflammatory changes

“…Therefore, there are differences in regard to fetal hemoglobin compared to the clinical situation in human neonates. In the neonatal blood higher concentrations of fetal hemoglobin are detected (71% +/- 7,7%) [14]. In healthy adults the proportion of fetal hemoglobin accounts for less than 2% (>18 years) [15], which has a stronger affinity to oxygen and therefore ensure a sufficient oxygen-supply during the fetal period [16].…”

Adult and fetal haemoglobin haemolytic disease of the newborn.

“…There is still controversy about the proportion of adult and fetal haemoglobin found in rhesus affected babies not treated by intraperitoneal transfusion. Jonxis (1948), Schulman and Smith (1954), Brody andEngstrom (1960), andOppe andFraser (1961) found an increase in the proportion of adult haemoglobin in the cord blood of babies with rhesus haemolytic disease, while Ponder and Levine (1949) did not.…”