Ferulic Acid Reduces Cell Viability through Its Apoptotic Efficacy: An In vitro Approach

Mechanisms of curcumin-based photodynamic therapy and its effects in combination with electroporation: An in vitro and molecular dynamics study

“…The degradation validated in this study (Figure 1B) was observed in the other research as well [17]. Photo-degradation derivatives of curcuminvanillin, ferulic acid, possess great biological activity [26,27,28].…”

“…The "PDT 0 h, ECT 3 h" therapy effectiveness among melanotic melanoma could be a result of the initial transformation of the curcumin into the ferulic acid and vanillin. High anticancer activity over A375 cell line of the small molecules has already been demonstrated before [26,28]. The molecular analysis of the therapy among all analyzed cell lines proves that there has to be a mechanism in which the cell absorbs the curcumin degradation products from the extracellular space -by pinocytosis, endocytosis or by the pores formed by oxidized lipids, formed during PDT [46,47].…”

“…Curcumin and the degradation-derivatives did not exhibit any significant role in fibroblasts death induction but rather physically destroy their integrity -by the disruption of the cell membrane integrity. Conversely, the melanoma cells are highly susceptible to curcumin-based therapies as well as vanillin or ferulic acid standalone treatment [28,26]. The small molecule compounds have been characterized by high activity against melanoma [27].…”

“…From the technical aspect, the procedure involves only hydrophilic chemotherapeutic molecules, thus ECT with amphipathic curcumin is not a proper therapeutic choice [25]. Although curcumin is amphipathic, the products of degradation of curcumin -vanillin, ferruloylmethane, acetone and ferulic acid are the hydrophilic compounds, therefore the combination of PDT with ECT could be characterized by some anticancer potential [26,27,28,29].…”

Ferulic acid: A natural compound as an efficient feed additive for GIFT (Oreochromis niloticus)

“…FA provides a high enzymatic antioxidant capacity to animals and has the vast potential to scavenge wide range of reactive oxygen species including superoxide and hydroxyl radicals as a phenolic bioflavonoid (Prabhakar, Manoharan, Rejitharaji, Selvasundaram, & Islam, ). Reactive radicals collide with FA to form phenoxy radicals, which are highly resonance stabilized since the unpaired electron may be delocalized across the entire molecular and the oxygen.…”